{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T15:06:46Z","timestamp":1784041606532,"version":"3.55.0"},"reference-count":49,"publisher":"Informa UK Limited","issue":"8","license":[{"start":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:00:00Z","timestamp":1646697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1080\/policies-text-data-mining"}],"funder":[{"DOI":"10.13039\/100005189","name":"Leukemia and Lymphoma Society","doi-asserted-by":"publisher","award":["Fellowship"],"award-info":[{"award-number":["Fellowship"]}],"id":[{"id":"10.13039\/100005189","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"crossref","award":["UL1TR000117"],"award-info":[{"award-number":["UL1TR000117"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"crossref","award":["UL1TR001998"],"award-info":[{"award-number":["UL1TR001998"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Institutes of Health, National Cancer Institute","award":["CA165469"],"award-info":[{"award-number":["CA165469"]}]},{"name":"National Institutes of Health, National Cancer Institute","award":["P30 CA177558"],"award-info":[{"award-number":["P30 CA177558"]}]},{"name":"National Institutes of Health, National Cancer Institute","award":["R01 CA217934"],"award-info":[{"award-number":["R01 CA217934"]}]},{"name":"National Institutes of Health, National Cancer Institute","award":["T32 CA165990"],"award-info":[{"award-number":["T32 CA165990"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Leukemia &amp; Lymphoma"],"published-print":{"date-parts":[[2022,7,3]]},"DOI":"10.1080\/10428194.2022.2045596","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T12:14:07Z","timestamp":1646741647000},"page":"1810-1822","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":2,"title":["Role of the splenic microenvironment in chronic lymphocytic leukemia development in E\u00b5-TCL1 transgenic mice"],"prefix":"10.1080","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4930-7188","authenticated-orcid":false,"given":"James P.","family":"Collard","sequence":"first","affiliation":[{"name":"Department of Microbiology, Immunology and Molecular Genetics and Markey Cancer Center, University of Kentucky","place":["Lexington, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2357-1733","authenticated-orcid":false,"given":"Mary K.","family":"McKenna","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Molecular Genetics and Markey Cancer Center, University of Kentucky","place":["Lexington, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0381-0864","authenticated-orcid":false,"given":"Sunil K.","family":"Noothi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Molecular Genetics and Markey Cancer Center, University of Kentucky","place":["Lexington, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara S.","family":"Alhakeem","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Molecular Genetics and Markey Cancer Center, University of Kentucky","place":["Lexington, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3949-1604","authenticated-orcid":false,"given":"Jacqueline R.","family":"Rivas","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Molecular Genetics and Markey Cancer Center, University of Kentucky","place":["Lexington, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek M.","family":"Rangnekar","sequence":"additional","affiliation":[{"name":"Department of Radiation Medicine and Markey Cancer Center, University of Kentucky","place":["Lexington"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0351-4504","authenticated-orcid":false,"given":"Natarajan","family":"Muthusamy","sequence":"additional","affiliation":[{"name":"Division of Hematology, James Cancer Center, Ohio State University","place":["Columbus"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subbarao","family":"Bondada","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Molecular Genetics and Markey Cancer Center, University of Kentucky","place":["Lexington, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2022,3,8]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21654"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.10.5715"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041720"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.102181599"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.268037"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1996.00305.x"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.8.2655"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/icb.1997.87"},{"key":"e_1_3_4_10_1","doi-asserted-by":"crossref","unstructured":"Mongini PKA Gupta R Boyle E et\u00a0al. TLR-9 and IL-15 synergy promotes the in\u00a0vitro clonal expansion of chronic lymphocytic leukemia B cells. J. Immunol. 2015; 195(3):901\u2013923.","DOI":"10.4049\/jimmunol.1403189"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2013.08.011"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2017015560"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.672735"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308648100"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800241"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-021-01217-1"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(01)00922-X"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.1.52"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011445"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1308374111"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.199"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2019.00001"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2010.0040"},{"issue":"37","key":"e_1_3_4_24_1","first-page":"37","article-title":"Roles for BLyS family members in meeting the distinct homeostatic demands of innate and adaptive B cells [review]","volume":"4","author":"Cancro M","year":"2013","unstructured":"Cancro M , Scholz J , Sindhava V. Roles for BLyS family members in meeting the distinct homeostatic demands of innate and adaptive B cells [review]. Front Immunol. 2013; 4(37):37.","journal-title":"Front Immunol"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-05-577122"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2015.07.009"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.135590"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-14-0096"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-08-802462"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-11-466250"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302821"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0404875101"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1042\/BC20070072"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-021-01136-1"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-014-0071-7"},{"key":"e_1_3_4_36_1","unstructured":"Newman T. Spleen: anatomy function and disease. Medical News Today. 2018. https:\/\/www.medicalnewstoday.com\/articles\/320698#diseases"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-200232060-00002"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-329870"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.217"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-05-431452"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-06-163303"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI73448"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-06-160713"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-07-515361"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-06-230169"},{"key":"e_1_3_4_46_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-04-497693"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-05-284638"},{"key":"e_1_3_4_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.125"},{"key":"e_1_3_4_49_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-12-258814"},{"key":"e_1_3_4_50_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-08-446732"}],"container-title":["Leukemia &amp; Lymphoma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/10428194.2022.2045596","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/full-xml\/10.1080\/10428194.2022.2045596","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/10428194.2022.2045596","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T14:39:14Z","timestamp":1784039954000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/10428194.2022.2045596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,8]]},"references-count":49,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,7,3]]}},"alternative-id":["10.1080\/10428194.2022.2045596"],"URL":"https:\/\/doi.org\/10.1080\/10428194.2022.2045596","relation":{},"ISSN":["1042-8194","1029-2403"],"issn-type":[{"value":"1042-8194","type":"print"},{"value":"1029-2403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,8]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ilal20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ilal20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2021-09-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-14","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}