{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T00:38:30Z","timestamp":1793752710456,"version":"4.6.1"},"reference-count":93,"publisher":"Informa UK Limited","issue":"12","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Leukemia &amp; Lymphoma"],"published-print":{"date-parts":[[2025,10,15]]},"DOI":"10.1080\/10428194.2025.2541024","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T15:47:19Z","timestamp":1754408839000},"page":"2168-2179","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":7,"title":["Extramedullary sites of disease in B-cell acute lymphoblastic leukemia: incidence, biology, and treatment"],"prefix":"10.1080","volume":"66","author":[{"given":"Vaibhav","family":"Agrawal","sequence":"first","affiliation":[{"name":"Department of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope National Medical Center","place":["Duarte, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Aldoss","sequence":"additional","affiliation":[{"name":"Department of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope National Medical Center","place":["Duarte, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Pullarkat","sequence":"additional","affiliation":[{"name":"Department of Hematology and Hematopoietic Cell Transplantation, Gehr Family Center for Leukemia Research, City of Hope National Medical Center","place":["Duarte, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,8,5]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-04-1623"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20668"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(05)70188-X"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V85.8.2025.bloodjournal8582025"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v99.3.863"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.10.050"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-05-018192"},{"key":"e_1_3_2_9_1","article-title":"Results of the simultaneous combination of ponatinib and blinatumomab in philadelphia chromosome-positive ALL","author":"Kantarjian H","unstructured":"Kantarjian H, et\u00a0al. Results of the simultaneous combination of ponatinib and blinatumomab in philadelphia chromosome-positive ALL. J Clin Oncol. 2024;42(36):4246-4251.","journal-title":"J Clin Oncol"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199310283291801"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2010.10.019"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860901)58:5<1024::AID-CNCR2820580507>3.0.CO;2-V"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33609"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14090875"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2017.03.023"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2013.04.014"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.03164.x"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2015.139"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-010-9256-x"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027042"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404684"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2019.04.003"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0342-5"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-020-00115-2"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-06-2530"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2020.38.15_suppl.e19516"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-10-881961"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.76.8192"},{"key":"e_1_3_2_29_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.3.547"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10265"},{"key":"e_1_3_2_31_1","article-title":"Other (non-CNS\/testicular) extramedullary localizations of childhood relapsed acute lymphoblastic leukemia and lymphoblastic lymphoma-a report from the ALL-REZ study group","author":"Lissat A","unstructured":"Lissat A, et\u00a0al. Other (non-CNS\/testicular) extramedullary localizations of childhood relapsed acute lymphoblastic leukemia and lymphoblastic lymphoma-a report from the ALL-REZ study group. J Clin Med. 2021;10(22):5292.","journal-title":"J Clin Med"},{"key":"e_1_3_2_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18537"},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022017035"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2008.04.011"},{"key":"e_1_3_2_35_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V72.5.1784.1784"},{"key":"e_1_3_2_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-11-4666"},{"key":"e_1_3_2_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2021.1894647"},{"key":"e_1_3_2_38_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024024838"},{"key":"e_1_3_2_39_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-02-140665"},{"key":"e_1_3_2_40_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021004813"},{"key":"e_1_3_2_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.5868"},{"key":"e_1_3_2_42_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2016272"},{"key":"e_1_3_2_43_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.01075"},{"key":"e_1_3_2_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26622"},{"key":"e_1_3_2_45_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2024-206602"},{"key":"e_1_3_2_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.currproblcancer.2018.04.006"},{"key":"e_1_3_2_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702645"},{"key":"e_1_3_2_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.07.005"},{"key":"e_1_3_2_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704223"},{"key":"e_1_3_2_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-020-04199-9"},{"issue":"10","key":"e_1_3_2_51_1","first-page":"1380","article-title":"Anti-leukemic effect of graft-versus-host disease on bone marrow and extramedullary relapses in acute leukemia","volume":"90","author":"Lee JH","year":"2005","unstructured":"Lee JH, et\u00a0al. Anti-leukemic effect of graft-versus-host disease on bone marrow and extramedullary relapses in acute leukemia. Haematologica. 2005;90(10):1380\u20131388.","journal-title":"Haematologica"},{"key":"e_1_3_2_52_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-077974"},{"key":"e_1_3_2_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.07.002"},{"key":"e_1_3_2_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2015.10.016"},{"key":"e_1_3_2_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-019-0790-x"},{"key":"e_1_3_2_56_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019001381"},{"key":"e_1_3_2_57_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2019.1576872"},{"key":"e_1_3_2_58_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1609783"},{"key":"e_1_3_2_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24783"},{"key":"e_1_3_2_60_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-02-834911"},{"key":"e_1_3_2_61_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.23262"},{"key":"e_1_3_2_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33967"},{"key":"e_1_3_2_63_1","doi-asserted-by":"publisher","DOI":"10.1177\/1078155220934853"},{"key":"e_1_3_2_64_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-99-117400"},{"key":"e_1_3_2_65_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S70524"},{"key":"e_1_3_2_66_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1509277"},{"key":"e_1_3_2_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-020-00345-8"},{"key":"e_1_3_2_68_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2021.280433"},{"key":"e_1_3_2_69_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2024.0967"},{"key":"e_1_3_2_70_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-018-0572-x"},{"key":"e_1_3_2_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25274"},{"key":"e_1_3_2_72_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709919"},{"key":"e_1_3_2_73_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.01892"},{"key":"e_1_3_2_74_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-11-883710"},{"key":"e_1_3_2_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01222-8"},{"key":"e_1_3_2_76_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003482"},{"key":"e_1_3_2_77_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-22-2038"},{"key":"e_1_3_2_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtct.2023.12.028"},{"key":"e_1_3_2_79_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021006035"},{"key":"e_1_3_2_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(21)00238-6"},{"key":"e_1_3_2_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01546-9"},{"key":"e_1_3_2_82_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021013733"},{"key":"e_1_3_2_83_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-001511"},{"key":"e_1_3_2_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2014.03.030"},{"key":"e_1_3_2_85_1","doi-asserted-by":"publisher","DOI":"10.1177\/1533033820956993"},{"key":"e_1_3_2_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24287"},{"key":"e_1_3_2_87_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020001466"},{"key":"e_1_3_2_88_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI85309"},{"key":"e_1_3_2_89_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709866"},{"key":"e_1_3_2_90_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.HS9.0000843344.19780.98"},{"key":"e_1_3_2_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15195"},{"key":"e_1_3_2_92_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-022-01379-0"},{"key":"e_1_3_2_93_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-021-03009-z"},{"key":"e_1_3_2_94_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-179454"}],"container-title":["Leukemia &amp; Lymphoma"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/10428194.2025.2541024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:01:08Z","timestamp":1764547268000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/10428194.2025.2541024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,5]]},"references-count":93,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,10,15]]}},"alternative-id":["10.1080\/10428194.2025.2541024"],"URL":"https:\/\/doi.org\/10.1080\/10428194.2025.2541024","relation":{},"ISSN":["1042-8194","1029-2403"],"issn-type":[{"value":"1042-8194","type":"print"},{"value":"1029-2403","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,5]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ilal20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ilal20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2024-11-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-14","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}