{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T21:17:12Z","timestamp":1773955032618,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:p>Antimitochondrial antibodies (AMAs) are the classic serologic\n            marker in primary biliary cirrhosis (PBC). However, there have been only\n             limited attempts to study changes in titer or isotype analysis of such AMAs in\n            patients followed for long periods of time<\/jats:p><jats:p>We took advantage of stored sera from well\u2010characterized patients with\n            PBC followed for a period of 7\u201028 years (mean duration of 13.5 years). Immunoblot\n            and enzyme\u2010linked immunosorbant assays were performed against PDC\u2010E2,\n            BCOADC\u2010E2 and OGDC\u2010E2 as well as isotype analysis of antigen\u2010specific IgG,\n            IgA and IgM antibodies against each of these mitochondrial autoantigens. Sera\n            were analyzed for total IgG, IgA and IgM by radial immunodiffusion. The sera titer\n            of AMAs was significantly higher in younger patients with PBC. Indeed, age of onset\n            of clinical PBC was a significant predictor for the highest values of sera AMAs. In\n            contrast, the AMA titer did not significantly change over time in this prolonged\n            longitudinal study. The total sera levels of the individual immunoglobulins did not\n            show a time\u2010dependent change, when based on age of onset of the disease. Higher\n             titers of AMAs were noted in the younger patients. Furthermore, despite this long\n             follow\u2010up, there was no evidence for a significant change in AMA levels; also, levels\n            were not influenced by drug therapy used during the period of observation.<\/jats:p>","DOI":"10.1080\/10446670410001722113","type":"journal-article","created":{"date-parts":[[2004,10,20]],"date-time":"2004-10-20T18:17:27Z","timestamp":1098296247000},"page":"129-133","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Serial Analysis of Antimitochondrial Antibody in Patients with Primary Biliary Cirrhosis"],"prefix":"10.1155","volume":"11","author":[{"given":"Gordon D.","family":"Benson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Miyakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitchell R.","family":"Watnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Eric","family":"Gershwin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,1]]},"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2004\/852358.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/10446670410001722113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T11:30:27Z","timestamp":1723116627000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1080\/10446670410001722113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["10.1080\/10446670410001722113"],"URL":"https:\/\/doi.org\/10.1080\/10446670410001722113","archive":["Portico"],"relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"value":"2314-8861","type":"print"},{"value":"2314-7156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,1]]},"assertion":[{"value":"2004-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}