{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T22:11:05Z","timestamp":1780351865827,"version":"3.54.1"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:p>The oxidative modification of low\u2010density lipoprotein (LDL) in the intima of\n            arteries contributes to the initiation and progression of atherosclerotic lesions.\n            We have previously reported that oxidized LDL (oxLDL) interacts with\n            an endogenous plasma protein, \u03b22\u2010glycoprotein I (\u03b22GPI), to form\n            complexes and that the interaction is mediated by oxLDL specific ligands. We have also\n            demonstrated the presence of oxLDL\/\u03b22GPI complexes in the blood stream\n            of patients with systemic inflammatory and autoimmune diseases. These findings\n            implicate that oxLDL\/\u03b22GPI complexes are possible atherogenic autoantigens.\n            Autoantibodies to oxLDL\/\u03b22GPI complexes have been associated with arterial\n            thrombosis. Further, circulating IgG immune complexes containing oxLDL and\n             2GPI were also detected in patients with systemic lupus erythematosus (SLE)\n             and\/or antiphospholipid syndrome (APS). Although many unanswered questions\n             remain about the exact pathogenic mechanism(s) involved, oxLDL\/\u03b22GPI\n             complexes may be described as metabolic products relevant in atherogenesis and as\n             significant participants in autoimmune\u2010mediated atherosclerosis.<\/jats:p>","DOI":"10.1080\/10446670410001722186","type":"journal-article","created":{"date-parts":[[2004,10,20]],"date-time":"2004-10-20T18:17:27Z","timestamp":1098296247000},"page":"103-111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Are Oxidized LDL\/\u03b22\u2010glycoprotein I Complexes Pathogenic Antigens in Autoimmune\u2010mediated Atherosclerosis?"],"prefix":"10.1155","volume":"11","author":[{"given":"Eiji","family":"Matsuura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis R.","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,1]]},"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2004\/313875.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/10446670410001722186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T11:30:14Z","timestamp":1723116614000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1080\/10446670410001722186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["10.1080\/10446670410001722186"],"URL":"https:\/\/doi.org\/10.1080\/10446670410001722186","archive":["Portico"],"relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"value":"2314-8861","type":"print"},{"value":"2314-7156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,1]]},"assertion":[{"value":"2004-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}