{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T15:09:36Z","timestamp":1790089776381,"version":"4.0.1"},"reference-count":19,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1080\/policies-text-data-mining"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Journal of Biopharmaceutical Statistics"],"DOI":"10.1080\/10543406.2026.2728047","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:53:01Z","timestamp":1790088781000},"page":"1-20","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Trial designs for assessing induction, maintenance and other treatment effects on a continuous endpoint"],"prefix":"10.1080","author":[{"given":"Hui","family":"Quan","sequence":"first","affiliation":[{"name":"Sanofi","place":["Morristown, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixing","family":"Xu","sequence":"additional","affiliation":[{"name":"Sanofi","place":["Morristown, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunfu","family":"Qiu","sequence":"additional","affiliation":[{"name":"Sanofi","place":["Morristown, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Chen","sequence":"additional","affiliation":[{"name":"Sanofi","place":["Morristown, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pst.502"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2011.04.006"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(02)00038-8"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.5728"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000069738"},{"key":"e_1_3_4_7_1","unstructured":"FDA. 2022a. Draft guidance: crohn\u2019s disease: developing drugs for treatment guidance for industry. [updated 2025 Sep 10]. https:\/\/www.fda.gov\/media\/158001\/download"},{"key":"e_1_3_4_8_1","volume-title":"Draft guidance: ulcerative colitis: developing drugs for treatment, guidance for industry","author":"FDA","year":"2022","unstructured":"FDA. 2022b. Draft guidance: ulcerative colitis: developing drugs for treatment, guidance for industry. [updated 2025 Sep 10]. https:\/\/www.fda.gov\/media\/158016\/download"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)91499-2"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4292"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0962280211431023"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.8288"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.9381"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2018.05.008"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.70382"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1996.10476908"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.3224"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)11509-4"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4412"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(14)00092-3"}],"container-title":["Journal of Biopharmaceutical Statistics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/10543406.2026.2728047","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/full-xml\/10.1080\/10543406.2026.2728047","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/10543406.2026.2728047","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:53:04Z","timestamp":1790088784000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/10543406.2026.2728047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,22]]},"references-count":19,"alternative-id":["10.1080\/10543406.2026.2728047"],"URL":"https:\/\/doi.org\/10.1080\/10543406.2026.2728047","relation":{},"ISSN":["1054-3406","1520-5711"],"issn-type":[{"value":"1054-3406","type":"print"},{"value":"1520-5711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,22]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=lbps20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=lbps20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2026-07-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}