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Final DSM\u2010III\u2010R diagnoses and Global Assessment Scale (C\u2010GAS) were assigned by best estimate. Substantial lifetime prevalences of mood (21%), anxiety (24%) and disruptive disorders (30%), school problems (37%), and global impairment (C\u2010GAS &lt; 61) (25%) were observed in the children of opiate\u2010dependent patients. There were few differences between ethnic groups. Effects of proband gender and major depression and their interactions with ethnicity on risk for childhood psychopathology were also examined. The results suggest children of patients in treatment for opiate dependence from diverse ethnic groups are at risk for psychopathology. 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