{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:51:52Z","timestamp":1789523512080,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2010,2,18]],"date-time":"2010-02-18T00:00:00Z","timestamp":1266451200000},"content-version":"vor","delay-in-days":2050,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American J Addict"],"published-print":{"date-parts":[[2004,7,9]]},"abstract":"<jats:p>This study evaluates whether patients with cocaine\u2010alcohol dependence might benefit from naltrexone (NTX) pharmacotherapy when delivered in conjunction with psychotherapy. Eighty outpatients meeting DSM\u2010IV criteria for alcohol and cocaine dependence were randomly assigned to receive NTX (placebo or 50mg\/d) combined with psychotherapy (Relapse Prevention [RP] or Drug Counseling [DC]) for twelve weeks. It was hypothesized that the skills training focus of RP therapy, in combination with NTX 50 mg\/d, would produce greater reductions in cocaine and alcohol use. Outcome measures included self\u2010 and objective reports of substance use, treatment retention, medication compliance, and adverse effects. During the first four weeks of treatment, the percentage of cocaine\u2010positive urine screens was significantly lower for those receiving RP therapy (22%) than those receiving DC (47%); however, this difference subsequently diminished. No medication effects were found. All groups reported less alcohol use at the end of treatment. Treatment retention was the same among the groups, with about 33% of the subjects completing all twelve weeks of treatment. The active medication group showed better medication compliance, while the number of adverse events was low overall and not significantly different by group. In conclusion, NTX at 50 mg\/d did not reduce cocaine or alcohol use. These findings stand in contrast to previously reported positive findings for NTX and RP in patients with a single diagnosis of cocaine dependence.<\/jats:p>","DOI":"10.1080\/10550490490480982","type":"journal-article","created":{"date-parts":[[2004,9,10]],"date-time":"2004-09-10T20:37:14Z","timestamp":1094848634000},"page":"333-341","source":"Crossref","is-referenced-by-count":46,"title":["Treatment of Cocaine\u2010Alcohol Dependence with Naltrexone and Relapse Prevention Therapy"],"prefix":"10.1111","volume":"13","author":[{"given":"Joy M.","family":"Schmitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela L.","family":"Stotts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelly L.","family":"Sayre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A.","family":"DeLaune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Grabowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,2,18]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.15288\/jsa.1993.54.199"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.15288\/jsa.2001.62.14"},{"key":"e_1_2_6_4_2","first-page":"390","article-title":"Cocaine: general characteristics, abuse, and addiction","volume":"89","author":"Miller NS","year":"1989","journal-title":"New York State Journal of Medicine"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(97)00069-0"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1994.tb00939.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0741-8329(91)90305-G"},{"key":"e_1_2_6_8_2","first-page":"94","article-title":"Cocaine effects on dopamine and opioid peptide neural systems: implications for human cocaine abuse","volume":"163","author":"Hurd YL","year":"1996","journal-title":"NIDA Res Monogr"},{"key":"e_1_2_6_9_2","first-page":"450","article-title":"Behavioral and biochemical evidence of opioidergic involvement in cocaine sensitization","volume":"274","author":"Sala M","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1998.tb03661.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02244173"},{"key":"e_1_2_6_12_2","first-page":"735","article-title":"Food deprivation and acquisition of intravenous cocaine self\u2010administration in rats: effect of naltrexone and haloperidol","volume":"251","author":"Vry J","year":"1989","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(91)90090-O"},{"key":"e_1_2_6_14_2","first-page":"216A","article-title":"Efficacy of natrexone for alcoholics with and without comorbid opiate or cocaine dependence","volume":"20","author":"McCaul ME","year":"1996","journal-title":"Alcohol Clin Exp Res"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050688"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0740-5472(98)00039-7"},{"key":"e_1_2_6_17_2","first-page":"886","volume-title":"Task Force on DSM\u2010IV Diagnostic and Statistical Manual of Mental Disorders: DSM\u2010IV","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.69.5.858"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1037\/1064-1297.4.1.46"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4603(00)00098-8"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1996.tb01142.x"},{"key":"e_1_2_6_22_2","volume-title":"Relapse Prevention: Maintenance Strategies in the Treatment of Addictive Behaviors","author":"Marlatt GA","year":"1985"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1983.04390010049006"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.50.1.49"},{"key":"e_1_2_6_25_2","volume-title":"Structured Clinical Interview for DSM\u2010IV Axis I Disorders\u2010Patient Edition (SCID\u2010I\/P). 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