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This study examined the effects of naltrexone compared to placebo on subjective responses to alcohol at the descending limb of the blood alcohol curve following a controlled intravenous (IV) alcohol administration. Non\u2010treatment\u2010seeking hazardous drinkers (n = 38) completed two double\u2010blind counterbalanced IV alcohol challenge sessions, one after taking naltrexone (50 mg) for three days and one after taking a placebo for three days. During each session, participants reported on subjective responses to alcohol during the descending limb of the blood alcohol curve. Analyses revealed significant main effects of naltrexone, reflecting significantly decreased alcohol\u2010induced stimulation, craving, vigor, positive mood, and alcohol \u201chigh\u201d and increased tension as compared to placebo. These findings suggest that naltrexone may exert some of its therapeutic effects via alterations to experiential aspects of intoxication during the descending limb of alcohol intoxication. Additionally, these results highlight the potential utility of considering limb of blood alcohol curve when examining the mechanisms of action of pharmacotherapies thought to alter subjective responses to alcohol.<\/jats:p>","DOI":"10.1080\/10550490802138400","type":"journal-article","created":{"date-parts":[[2008,7,9]],"date-time":"2008-07-09T05:18:59Z","timestamp":1215580739000},"page":"257-264","source":"Crossref","is-referenced-by-count":24,"title":["Effects of Naltrexone During the Descending Limb of the Blood Alcohol Curve"],"prefix":"10.1111","volume":"17","author":[{"given":"Lara A.","family":"Ray","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kent 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