{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:39:42Z","timestamp":1790163582061,"version":"4.1.0"},"reference-count":47,"publisher":"Informa UK Limited","issue":"8","funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["CNPq"],"award-info":[{"award-number":["CNPq"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["n\u00ba 444983\/2014-7"],"award-info":[{"award-number":["n\u00ba 444983\/2014-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Rio de Janeiro State Research Agency","award":["FAPERJ"],"award-info":[{"award-number":["FAPERJ"]}]},{"name":"Rio de Janeiro State Research Agency","award":["n\u00ba E-26\/111.781\/2013"],"award-info":[{"award-number":["n\u00ba E-26\/111.781\/2013"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Clinical and Experimental Hypertension"],"published-print":{"date-parts":[[2018,11,17]]},"DOI":"10.1080\/10641963.2018.1425423","type":"journal-article","created":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T15:30:35Z","timestamp":1516721435000},"page":"721-729","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":11,"title":["Tempol, a superoxide dismutase-mimetic drug, prevents chronic ischemic renal injury in two-kidney, one-clip hypertensive rats"],"prefix":"10.1080","volume":"40","author":[{"given":"Douglas VQ.","family":"Nunes","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiane A.","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graziele F.","family":"De Bem","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane SC.","family":"Cordeiro","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabelle B.","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenize CRM.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro K.","family":"Jord\u00e3o","sequence":"additional","affiliation":[{"name":"University Unit of Pharmacy, State University of the West Zone, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna C","family":"Cunha","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Fluminense Federal University, Niter\u00f3i, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor F","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Fluminense Federal University, Niter\u00f3i, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto S","family":"Moura","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela C.","family":"Resende","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayane T.","family":"Ognibene","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2018,1,23]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000467473.21331.70"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1053\/j.tvir.2016.06.006"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2010.05437.x"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2002.125016"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2009.180"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1084\/jem.59.3.347"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201x.2000.00630.x"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.2174\/15734021113099990007"},{"key":"CIT0009","first-page":"170","volume":"13","author":"Navar LG","year":"1998","journal-title":"News Physiol Sci Int J Physiol Prod Jointly Int Union Physiol Sci Am Physiol Soc"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000135483.12297.e4"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.18.2206"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.74.6.1141"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2013.04.021"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2006.8.1597"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399411001815"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-015-0095-3"},{"key":"CIT0017","first-page":"692","volume":"41","author":"Welch WJ","year":"2003","journal-title":"Hypertens Dallas Tex 1979"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00113.2007"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.4314\/ajtcam.v11i5.3"},{"key":"CIT0020","first-page":"298","volume":"55","author":"Palm F","year":"2010","journal-title":"Hypertens Dallas Tex 1979"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000200511.02700.99"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1021\/bi00463a024"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2010.01.003"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161706"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2009.186"},{"key":"CIT0026","first-page":"1154","volume":"46","author":"Xu H","year":"2005","journal-title":"Hypertens Dallas Tex 1979"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00392.x"},{"key":"CIT0028","first-page":"1346","volume":"41","author":"Meng S","year":"2003","journal-title":"Hypertens Dallas Tex 1979"},{"key":"CIT0029","first-page":"1058","volume":"51","author":"Hoffmann DS","year":"2008","journal-title":"Hypertens Dallas Tex 1979"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1080\/00397917508065573"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2011.02.026"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1965.sp007572"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1590\/S0001-37652003000400006"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1007\/BF00381877"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2009.02.002"},{"key":"CIT0037","first-page":"1080","volume":"48","author":"Xu H","year":"2006","journal-title":"Hypertens Dallas Tex 1979"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2009.09.002"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2010.64"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2014.02.001"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2014.079889"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00001.2015"},{"issue":"110","key":"CIT0043","first-page":"646","volume":"2011","author":"Han Y","year":"1985","journal-title":"J Appl Physiol Bethesda Md"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2007.12"},{"key":"CIT0045","first-page":"624","volume":"39","author":"Ren Y","year":"2002","journal-title":"Hypertens Dallas Tex 1979"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-012-0798-z"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg271"}],"container-title":["Clinical and Experimental Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/10641963.2018.1425423","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T09:48:30Z","timestamp":1597744110000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/10641963.2018.1425423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,23]]},"references-count":47,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,11,17]]}},"alternative-id":["10.1080\/10641963.2018.1425423"],"URL":"https:\/\/doi.org\/10.1080\/10641963.2018.1425423","relation":{},"ISSN":["1064-1963","1525-6006"],"issn-type":[{"value":"1064-1963","type":"print"},{"value":"1525-6006","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,23]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iceh20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iceh20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2017-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-12-26","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-12-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}