{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T12:05:20Z","timestamp":1770984320376,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Infectious Diseases in Obstetrics and Gynecology"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:p><jats:italic>Objective:<\/jats:italic> To assess the efficacy of 2% clindamycin vaginal cream (CVC) to treat bacterial vaginosis (BV) in\n              pregnancy.<\/jats:p><jats:p><jats:italic>Methods:<\/jats:italic> A prospective, randomized, double\u2010blind, placebo\u2010controlled, tricenter study. Four hundred and four\nwomen with BV on Gram stain at their first antenatal clinic visit were randomized to receive a 3\u2010day course of\n2% CVC or placebo. The outcome was assessed using an intention to treat analysis at 3 weeks and 6 weeks\npost\u2010treatment according to three different diagnostic methods based on five criteria (Gram stain and all four\nelements of clinical composite criteria: vaginal discharge, abnormal vaginal pH, clue cells, amine odor), three\ncriteria (vaginal pH, clue cells, amine odor) or two criteria (clue cells and amine odor) to reflect stringency of\ndiagnosis, historical precedence and government agency recommendations respectively.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> Using five diagnostic criteria, 18% of CVC patients were cured and 70.8% either cured and\/or improved\ncompared to 1.6% and 12% of placebo patients respectively (<jats:italic>p<\/jats:italic> &lt; 0.0001). Using three diagnostic criteria, 44.8%\nof CVC patients were cured and 77.3% were either cured and\/or improved compared to 9.3% and 28.8% of\nplacebo patients respectively (<jats:italic>p<\/jats:italic> &lt; 0.0001). Using two diagnostic criteria, 75.0% of CVC patients were cured\ncompared to 18.0% of placebo patients (p &lt; 0.0001). Recurrence rates in those CVC patients successfully treated\nwere approximately 6% at 6 weeks post baseline and 10% at 28 to 34 weeks gestation.<\/jats:p><jats:p><jats:italic>Conclusions:<\/jats:italic>  A 3\u2010day course of CVC appears to be well tolerated by the mother and statistically significantly\nmore efficacious than placebo in the treatment of BV during the second trimester of pregnancy.<\/jats:p>","DOI":"10.1080\/10647440300025519","type":"journal-article","created":{"date-parts":[[2005,9,7]],"date-time":"2005-09-07T07:22:30Z","timestamp":1126077750000},"page":"181-189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["The Efficacy of Vaginal Clindamycin for the Treatment ofAbnormal Genital Tract Flora in Pregnancy"],"prefix":"10.1155","volume":"11","author":[{"given":"Ronald F.","family":"Lamont","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian M.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debashis","family":"Mandal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip E.","family":"Hay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Sheehan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,7,16]]},"container-title":["Infectious Diseases in Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/idog\/2003\/425635.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/10647440300025519","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T21:29:10Z","timestamp":1723066150000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1080\/10647440300025519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["10.1080\/10647440300025519"],"URL":"https:\/\/doi.org\/10.1080\/10647440300025519","archive":["Portico"],"relation":{},"ISSN":["1064-7449"],"issn-type":[{"value":"1064-7449","type":"print"}],"subject":[],"published":{"date-parts":[[2003,1]]},"assertion":[{"value":"2002-10-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2003-07-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2003-07-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}