{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T13:11:18Z","timestamp":1791551478256,"version":"4.3.4"},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Infectious Diseases in Obstetrics and Gynecology"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:p><jats:italic>Objective:<\/jats:italic> To compare the relative effects of intrapartum antibiotic prophylaxis regimens on patterns of\nearly\u2010onset neonatal sepsis.<\/jats:p><jats:p><jats:italic>Methods:<\/jats:italic> We performed an historical cohort study of 17 187 infants born at our center from September 1993\nto February 2000. A risk\u2010based strategy was employed prior to July 1996 and a screening\u2010based strategy was\nutilized thereafter. Ampicillin was utilized prior to March 1995 and penicillin was used thereafter.<\/jats:p><jats:p><jats:italic>Results:<\/jats:italic> There were 75 cases of neonatal sepsis, 34 (4.10\/1000) in the risk\u2010based era and 41 (4.63\/1000) in the\nscreening\u2010based era (<jats:italic>p<\/jats:italic> = 0.62). There were fewer ampicillin\u2010resistant isolates during the risk\u2010based than\nthe screening\u2010based era (32 versus 61%; <jats:italic>p<\/jats:italic> = 0.014). The only significant change in organism\u2010specific sepsis\nrates was an increase in the rate of infection caused by coagulase\u2010negative staphylococci in the screening\u2010based\nera (0.36 versus 1.46\/1000; <jats:italic>p<\/jats:italic> = 0.018), but 75% of infants infected with these organisms were not exposed to\n\u00df\u2010lactam antibiotics within 72 h prior to delivery. For the risk\u2010 and screening\u2010based eras, respectively, the rates\nof Gram\u2010negative sepsis (1.21 versus 1.46\/1000; <jats:italic>p<\/jats:italic> = 0.65) and the proportions of Gram\u2010negative pathogens\nthat were ampicillin\u2010resistant (70 versus 77%; <jats:italic>p<\/jats:italic> = 1.0) were similar. The drug employed for prophylaxis did\nnot appear to affect the pattern of sepsis cases.<\/jats:p><jats:p><jats:italic>Conclusion:<\/jats:italic>  In our patient population, coagulase\u2010negative staphylococci have become the most common cause\nof early\u2010onset neonatal sepsis. The cause of this shift in pathogen prevalence is uncertain and seemingly unrelated\nto intrapartum antibiotic exposure.<\/jats:p>","DOI":"10.1080\/10647440300025525","type":"journal-article","created":{"date-parts":[[2005,9,7]],"date-time":"2005-09-07T07:22:30Z","timestamp":1126077750000},"page":"221-226","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Intrapartum Antibiotic Prophylaxis and Early\u2010Onset NeonatalSepsis Patterns"],"prefix":"10.1155","volume":"11","author":[{"given":"Rodney K.","family":"Edwards","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whitney E.","family":"Jamie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Sterner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Gentry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy","family":"Counts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Duff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,8,24]]},"container-title":["Infectious Diseases in Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/idog\/2003\/459392.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/10647440300025525","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T21:29:05Z","timestamp":1723066145000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1080\/10647440300025525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["10.1080\/10647440300025525"],"URL":"https:\/\/doi.org\/10.1080\/10647440300025525","archive":["Portico"],"relation":{},"ISSN":["1064-7449"],"issn-type":[{"value":"1064-7449","type":"print"}],"subject":[],"published":{"date-parts":[[2003,1]]},"assertion":[{"value":"2003-05-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2003-08-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2003-08-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}