{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T21:17:33Z","timestamp":1781644653471,"version":"3.54.5"},"reference-count":54,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Drug Delivery"],"published-print":{"date-parts":[[2019,1,1]]},"DOI":"10.1080\/10717544.2019.1582729","type":"journal-article","created":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T13:02:42Z","timestamp":1553173362000},"page":"318-327","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":43,"title":["Poly(3-hydroxybutyrate-CO-3-hydroxyvalerate) PHBHV biocompatible nanocarriers for 5-FU delivery targeting colorectal cancer"],"prefix":"10.1080","volume":"26","author":[{"given":"Ionut Cristian","family":"Radu","sequence":"first","affiliation":[{"name":"Advanced Polymer Materials Group, University Politehnica of Bucharest, Bucharest, Romania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariana","family":"Hudita","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Bucharest, Bucharest, Romania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalin","family":"Zaharia","sequence":"additional","affiliation":[{"name":"Advanced Polymer Materials Group, University Politehnica of Bucharest, Bucharest, Romania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8093-1750","authenticated-orcid":false,"given":"Bianca","family":"Galateanu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Bucharest, Bucharest, Romania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horia","family":"Iovu","sequence":"additional","affiliation":[{"name":"Advanced Polymer Materials Group, University Politehnica of Bucharest, Bucharest, Romania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia (Vasile)","family":"Tanasa","sequence":"additional","affiliation":[{"name":"University Politehnica of Bucharest, Bucharest, Romania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Georgiana Nitu","sequence":"additional","affiliation":[{"name":"National Research and Development Institute for Chemistry and Petrochemistry \u2013 ICECHIM, Bucharest, Romania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octav","family":"Ginghina","sequence":"additional","affiliation":[{"name":"Department of Surgery, Sf. Ioan Emergency Clinical Hospital, Bucharest, Romania;"},{"name":"Department II, Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy Bucharest, Bucharest, Romania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Negrei","sequence":"additional","affiliation":[{"name":"Department of Toxicology, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, Bucharest;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aristidis","family":"Tsatsakis","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Forensic Sciences, Faculty of Medicine, University of Crete, Heraklion, Greece;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Velonia","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Technology, University of Crete, Heraklion, Greece;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail","family":"Shtilman","sequence":"additional","affiliation":[{"name":"Department of Polymers, D.I. Mendeleyev University of Chemical Technology, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marieta","family":"Costache","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, University of Bucharest, Bucharest, Romania;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2019,3,21]]},"reference":[{"key":"CIT0001","doi-asserted-by":"crossref","unstructured":"Amass W, Amass A, Tighe B. (1998). A review of biodegradable polymers: uses, current developments in the synthesis and characterization of biodegradable polyesters, blends of biodegradable polymers and recent advances in biodegradation studies. Pol Int 47:89\u2013144.","DOI":"10.1002\/(SICI)1097-0126(1998100)47:2<89::AID-PI86>3.0.CO;2-F"},{"key":"CIT0002","doi-asserted-by":"crossref","unstructured":"Andr\u00e9 T, Boni C, Mounedji-Boudiaf L, et al. (2004). Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med 350:2343\u201351.","DOI":"10.1056\/NEJMoa032709"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg100"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.3109\/03602532.2015.1130052"},{"key":"CIT0005","doi-asserted-by":"crossref","unstructured":"Casarin SA, Malmonge SM, Kobayashi M, Agnelli JAM. (2011). Study on in-vitro degradation of bioabsorbable polymers poly (hydroxybutyrate-co-valerate) \u2013 (PHBV) and poly (caprolactone) \u2013 (PCL) %. J Biomater Nanobiotechnol 2:207\u2013215.","DOI":"10.4236\/jbnb.2011.23026"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.09.047"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601676"},{"key":"CIT0008","doi-asserted-by":"crossref","unstructured":"Cutsem EV, Moiseyenko VM, Tjulandin S, et al. (2006). Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: a report of the V325 study group. J Clin Oncol 24:4991\u20134997.","DOI":"10.1200\/JCO.2006.06.8429"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-198916040-00002"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1186\/s12989-017-0199-z"},{"key":"CIT0011","first-page":"999","volume-title":"Computer aided chemical engineering","author":"Ferreira LS","year":"2009"},{"key":"CIT0012","doi-asserted-by":"crossref","unstructured":"Galindo-Rodriguez S, All\u00e9mann E, Fessi H, Doelker EJPR. (2004). Physicochemical parameters associated with nanoparticle formation in the salting-out, emulsification-diffusion, and nanoprecipitation methods. Pharmaceutical Res 21:1428\u20131439.","DOI":"10.1023\/B:PHAM.0000036917.75634.be"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1021\/bc00034a002"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.16.2938"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801763105"},{"key":"CIT0016","doi-asserted-by":"crossref","unstructured":"Harris BE, Carpenter JT, Diasio RB. (1991). Severe 5-fluorouracil toxicity secondary to dihydropyrimidine dehydrogenase deficiency. A potentially more common pharmacogenetic syndrome. Cancer 68:499\u2013501.","DOI":"10.1002\/1097-0142(19910801)68:3<499::AID-CNCR2820680309>3.0.CO;2-F"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.7150\/jca.18171"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1039\/C6PY00676K"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.3109\/10717544.2014.926574"},{"key":"CIT0020","doi-asserted-by":"crossref","unstructured":"Jemal A, Siegel R, Ward E, et al. (2008). Cancer statistics. CA Cancer J Clin 58:71\u201396.","DOI":"10.3322\/CA.2007.0010"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.3109\/10717544.2015.1039667"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2175-7"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgv086"},{"key":"CIT0024","doi-asserted-by":"crossref","unstructured":"Krook JE, Moertel CG, Gunderson LL, et al. (1991). Effective surgical adjuvant therapy for high-risk rectal carcinoma. N Engl J Med 324:709\u201315.","DOI":"10.1056\/NEJM199103143241101"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2009.09.001"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2016.11.006"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1533\/9781845693640.83"},{"key":"CIT0028","author":"Leong J","year":"2018","journal-title":"Nanomedicine 14:2666"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.3281"},{"key":"CIT0030","doi-asserted-by":"crossref","unstructured":"Luss AL, Kulikov PP, Romme SB, et al. (2018). Nanosized carriers based on amphiphilic poly-N-vinyl-2-pyrrolidone for intranuclear drug delivery. Nanomedicine (Lond) 13:703\u201315.","DOI":"10.2217\/nnm-2017-0311"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1002\/ags3.12061"},{"key":"CIT0032","doi-asserted-by":"crossref","unstructured":"Meyerhardt JA, Catalano PJ, Haller DG, et al. (2003). Impact of diabetes mellitus on outcomes in patients with colon cancer. J Clin Oncol 21:433\u201340.","DOI":"10.1200\/JCO.2003.07.125"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2009.10.018"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11942"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-016-1797-5"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2010.03892.x"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymer.2006.01.038"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2005.12.003"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2016.03.003"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2007.05.040"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1039\/C6PY01365A"},{"key":"CIT0042","doi-asserted-by":"crossref","unstructured":"Radu I-C, Hudita A, Zaharia C, et al. (2017). Poly(hydroxybutyrate-co-hydroxyvalerate) (PHBHV) nanocarriers for silymarin release as adjuvant therapy in colo-rectal cancer. Frontiers in Pharmacology 8:508.","DOI":"10.3389\/fphar.2017.00508"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2004.12.016"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21332"},{"key":"CIT0045","doi-asserted-by":"crossref","unstructured":"Taghizadehghalehjoughi A, Hacimuftuoglu A, Cetin M, et al. (2018). Effect of metformin\/irinotecan-loaded poly-lactic-co-glycolic acid nanoparticles on glioblastoma: in vitro and in vivo studies. Nanomedicine (Lond) 13:1595\u2013606.","DOI":"10.2217\/nnm-2017-0386"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-00477-3_1"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.0106"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2018.07.006"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.3390\/ma2020307"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00839-9"},{"key":"CIT0051","first-page":"80","volume":"4","author":"Weiss-Angeli V","year":"2008","journal-title":"J Biomed Nanotechnol"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199806000-00003"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2016.1189465"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1039\/C7PY01603D"}],"container-title":["Drug Delivery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/10717544.2019.1582729","content-type":"application\/pdf","content-version":"am","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/10717544.2019.1582729","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T16:47:19Z","timestamp":1657126039000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/10717544.2019.1582729"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,1]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1,1]]}},"alternative-id":["10.1080\/10717544.2019.1582729"],"URL":"https:\/\/doi.org\/10.1080\/10717544.2019.1582729","relation":{},"ISSN":["1071-7544","1521-0464"],"issn-type":[{"value":"1071-7544","type":"print"},{"value":"1521-0464","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,1]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=idrd20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=idrd20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2019-01-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-11","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}