{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T10:34:07Z","timestamp":1788690847037,"version":"build-2803163510"},"reference-count":54,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Drug Delivery"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1080\/10717544.2021.1931561","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T19:39:26Z","timestamp":1622576366000},"page":"1043-1054","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":34,"title":["Oral gel loaded with penciclovir\u2013lavender oil nanoemulsion to enhance bioavailability and alleviate pain associated with herpes labialis"],"prefix":"10.1080","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4904-1378","authenticated-orcid":false,"given":"Khaled M.","family":"Hosny","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia"},{"name":"Center of Excellence for Drug Research and Pharmaceutical Industries, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5286-1756","authenticated-orcid":false,"given":"Amal M.","family":"Sindi","sequence":"additional","affiliation":[{"name":"Oral Diagnostic Sciences Department, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hala M.","family":"Alkhalidi","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mallesh","family":"Kurakula","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, The Herff College of Engineering, Memphis, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2358-4259","authenticated-orcid":false,"given":"Nabil K.","family":"Alruwaili","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy, Jouf University, Sakaka, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3826-1519","authenticated-orcid":false,"given":"Nabil A.","family":"Alhakamy","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia"},{"name":"Center of Excellence for Drug Research and Pharmaceutical Industries, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walaa A.","family":"Abualsunun","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana B.","family":"Bakhaidar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahaf H.","family":"Bahmdan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3088-4084","authenticated-orcid":false,"given":"Waleed Y.","family":"Rizg","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia"},{"name":"Center of Excellence for Drug Research and Pharmaceutical Industries, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah A.","family":"Ali","sequence":"additional","affiliation":[{"name":"Oral Diagnostic Sciences Department, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesam H.","family":"Abdulaal","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Science, Cancer and Mutagenesis Unit, King Fahd Center for Medical Research, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majed S.","family":"Nassar","sequence":"additional","affiliation":[{"name":"Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed S.","family":"Alsuabeyl","sequence":"additional","affiliation":[{"name":"Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel F.","family":"Alghaith","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sultan","family":"Alshehri","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia"},{"name":"Department of Pharmaceutical Sciences, College of Pharmacy, Almaarefa University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,6]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2021.1879314"},{"key":"e_1_3_4_3_1","first-page":"70","article-title":"Topical treatment of herpes simplex lesion by lavender cream","volume":"24","author":"Altaei T","year":"2012","unstructured":"Altaei T, Ahmed SA. (2012). Topical treatment of herpes simplex lesion by lavender cream. J Bagh Coll Dent 24:70\u20136.","journal-title":"J Bagh Coll Dent"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.15171\/apb.2016.051"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2009.03.008"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12273"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24183270"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2014.08.120"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1993.tb04673.x"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2015.999038"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom9040138"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25143166"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S66180"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-010-9544-3"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-1999-14045"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21060786"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/0250-474X.159596"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-019-1496-7"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2020.03.009"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2021.1909179"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2020.102108"},{"key":"e_1_3_4_22_1","first-page":"179","volume-title":"Chapter 7 - Natural surfactants-based micro\/nanoemulsion systems for NSAIDs\u2014practical formulation approach, physicochemical and biopharmaceutical characteristics\/performances","author":"Isailovi\u0107 TM","year":"2017","unstructured":"Isailovi\u0107 TM, Todosijevi\u0107 MN, \u0110or\u0111evi\u0107 SM, Savi\u0107 SD. (2017). Chapter 7 - Natural surfactants-based micro\/nanoemulsion systems for NSAIDs\u2014practical formulation approach, physicochemical and biopharmaceutical characteristics\/performances. Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs. In: \u010calija BBT-M, NC for NA-ID, editor. Boston (MA): Academic Press, 179\u2013217.."},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics10040275"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/app9224744"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/1934578X0800300727"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25071703"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026618666181025104818"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00264233"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S86845"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/681304"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.5604\/17322693.1067687"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S2.3.419"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2009.02.013"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.13.4.547"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/03639040802592443"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1080\/03639045.2017.1291672"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.3109\/10837450.2013.829092"},{"key":"e_1_3_4_38_1","first-page":"1683","article-title":"Treatment and prevention of herpes labialis","volume":"54","author":"Opstelten W","year":"2008","unstructured":"Opstelten W, Neven AK, Eekhof J. (2008). Treatment and prevention of herpes labialis. Can Fam Physician 54:1683\u20137.","journal-title":"Can Fam Physician"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2006.04.001"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.5650\/jos.60.155"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/08982104.2018.1524484"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.4103\/jfmpc.jfmpc_807_19"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.1159\/000080214"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-012-9821-4"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2021.102482"},{"key":"e_1_3_4_46_1","doi-asserted-by":"crossref","unstructured":"Spruance SL Rea TL Thoming C et al. (1997). Penciclovir cream for the treatment of herpes simplex labialis. A randomized multicenter double-blind placebo-controlled trial. Topical penciclovir collaborative study group. 277:1374\u20139.","DOI":"10.1001\/jama.277.17.1374"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(01)00180-6"},{"key":"e_1_3_4_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(01)00231-9"},{"key":"e_1_3_4_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2016.03.003"},{"key":"e_1_3_4_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/ed058p880"},{"key":"e_1_3_4_51_1","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2013.109"},{"key":"e_1_3_4_52_1","first-page":"289","article-title":"The influence of liposome on penciclovir penetration through mouse skin","volume":"40","author":"Yang LP","year":"2005","unstructured":"Yang LP, Wang WH. (2005). The influence of liposome on penciclovir penetration through mouse skin. Chin Pharm J 40:289\u201391.","journal-title":"Chin Pharm J"},{"key":"e_1_3_4_53_1","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2013.011"},{"key":"e_1_3_4_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2009.05.019"},{"key":"e_1_3_4_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2008.04.008"}],"container-title":["Drug Delivery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/10717544.2021.1931561","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T15:42:16Z","timestamp":1724168536000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/10717544.2021.1931561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":54,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1080\/10717544.2021.1931561"],"URL":"https:\/\/doi.org\/10.1080\/10717544.2021.1931561","relation":{},"ISSN":["1071-7544","1521-0464"],"issn-type":[{"value":"1071-7544","type":"print"},{"value":"1521-0464","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=idrd20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=idrd20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2021-04-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-04","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}