{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:17:14Z","timestamp":1788826634928,"version":"build-2803163510"},"reference-count":51,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Drug Delivery"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1080\/10717544.2021.1989089","type":"journal-article","created":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T12:32:21Z","timestamp":1635856341000},"page":"2289-2300","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":22,"title":["Spironolactone hyaluronic acid enriched cerosomes (HAECs) for topical management of hirsutism:\n            <i>in silico<\/i>\n            studies, statistical optimization,\n            <i>ex vivo,<\/i>\n            and\n            <i>in\u00a0vivo<\/i>\n            studies"],"prefix":"10.1080","volume":"28","author":[{"given":"Rofida","family":"Albash","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, Giza, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdurrahman M.","family":"Fahmy","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed I.A.","family":"Hamed","sequence":"additional","affiliation":[{"name":"Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, Fayoum University, Fayoum, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled M.","family":"Darwish","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania Moataz","family":"El-Dahmy","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, October 6 University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,11,2]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2016.10.006"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2015.03.020"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2017.02.030"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2017.10.170"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2018.07.005"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2018.1436098"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2011.10.043"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2010.488260"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2020.1859000"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2020.105510"},{"key":"e_1_3_2_12_1","article-title":"A thermostat for molecular dynamics of complex fluids","volume":"33","author":"Allen M","year":"2006","unstructured":"Allen M, Schmid F. (2006). A thermostat for molecular dynamics of complex fluids. Mol Simul 33","journal-title":"Mol Simul"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2015.03.033"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2017.03.005"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-021-02003-z"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2007.05.061"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.08.061"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2010.03.008"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2004.01180.x"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1985.tb02305.x"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2014.01.004"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2003.11.002"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1sm05181d"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2010.11.062"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2019.02.031"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.60.6.0002"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/03639045.2011.590731"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2017.1410262"},{"key":"e_1_3_2_29_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S297634"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-011-9653-7"},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/10837450.2021.1874011"},{"key":"e_1_3_2_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2011.04.027"},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcatb.2006.02.019"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-016-0621-0"},{"key":"e_1_3_2_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/10837450701481181"},{"key":"e_1_3_2_36_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-013-0034-2"},{"key":"e_1_3_2_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.08.034"},{"key":"e_1_3_2_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2008.05.031"},{"key":"e_1_3_2_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/08982104.2021.1918151"},{"key":"e_1_3_2_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/03639045.2021.1890111"},{"key":"e_1_3_2_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-020-02891-z"},{"key":"e_1_3_2_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/03639045.2017.1318899"},{"key":"e_1_3_2_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2010.03.011"},{"key":"e_1_3_2_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2019.01.035"},{"key":"e_1_3_2_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/1061186X.2020.1830408"},{"key":"e_1_3_2_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2012.08.009"},{"key":"e_1_3_2_47_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S73010"},{"key":"e_1_3_2_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14486"},{"key":"e_1_3_2_49_1","doi-asserted-by":"publisher","DOI":"10.2174\/156802608786786624"},{"key":"e_1_3_2_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/la9010899"},{"key":"e_1_3_2_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics11060257"},{"key":"e_1_3_2_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2736(96)00167-8"}],"container-title":["Drug Delivery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/10717544.2021.1989089","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T15:33:02Z","timestamp":1724167982000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/10717544.2021.1989089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1080\/10717544.2021.1989089"],"URL":"https:\/\/doi.org\/10.1080\/10717544.2021.1989089","relation":{},"ISSN":["1071-7544","1521-0464"],"issn-type":[{"value":"1071-7544","type":"print"},{"value":"1521-0464","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=idrd20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=idrd20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2021-08-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-21","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}