{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T00:44:27Z","timestamp":1792975467785,"version":"4.5.0"},"reference-count":48,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T00:00:00Z","timestamp":1641340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T00:00:00Z","timestamp":1641340800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1080\/policies-text-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872415"],"award-info":[{"award-number":["81872415"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Drug Delivery"],"published-print":{"date-parts":[[2022,12,31]]},"DOI":"10.1080\/10717544.2021.2023697","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T05:14:38Z","timestamp":1641359678000},"page":"192-202","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":57,"title":["Amplification of anticancer efficacy by co-delivery of doxorubicin and lonidamine with extracellular vesicles"],"prefix":"10.1080","volume":"29","author":[{"given":"Huizhen","family":"Li","sequence":"first","affiliation":[{"name":"Department of Biomaterials, The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province, Research Center of Biomedical Engineering of Xiamen, College of Materials, Xiamen University","place":["Xiamen, China"]},{"name":"Department of Radiotherapy, The First Affiliated Hospital of Zhengzhou University, Zhengdong Branch","place":["Zhengzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Biomaterials, The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province, Research Center of Biomedical Engineering of Xiamen, College of Materials, Xiamen University","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, The First Affiliated Hospital of Xiamen University","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biomaterials, The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province, Research Center of Biomedical Engineering of Xiamen, College of Materials, Xiamen University","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianwu","family":"Wang","sequence":"additional","affiliation":[{"name":"Xiamen Nuokangde Biological Technology Co., Ltd","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaojun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Xiamen Nuokangde Biological Technology Co., Ltd","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Biomaterials, The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province, Research Center of Biomedical Engineering of Xiamen, College of Materials, Xiamen University","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu","family":"Li","sequence":"additional","affiliation":[{"name":"Xiamen Nuokangde Biological Technology Co., Ltd","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8707-7446","authenticated-orcid":false,"given":"Liping","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Biomaterials, The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province, Research Center of Biomedical Engineering of Xiamen, College of Materials, Xiamen University","place":["Xiamen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2022,1,5]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.08.018"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jev2.12163"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03233-y"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9020133"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4800(87)90027-X"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208627"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(98)00054-9"},{"key":"e_1_3_4_9_1","first-page":"4661","article-title":"Effect of lonidamine on the energy metabolism of Ehrlich ascites tumor cells","volume":"41","author":"Floridi A","year":"1981","unstructured":"Floridi A, Paggi MG, D'Atri S, et\u00a0al. (1981a). Effect of lonidamine on the energy metabolism of Ehrlich ascites tumor cells. Cancer Research 41:4661.","journal-title":"Cancer Research"},{"key":"e_1_3_4_10_1","first-page":"497","article-title":"Lonidamine, a selective inhibitor of aerobic glycolysis of murine tumor cells","volume":"66","author":"Floridi A","year":"1981","unstructured":"Floridi A, Paggi MG, Marcante ML, et\u00a0al. (1981b). Lonidamine, a selective inhibitor of aerobic glycolysis of murine tumor cells. J Natl Cancer Inst 66:497\u20139.","journal-title":"J Natl Cancer Inst"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.638357"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.05.015"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26061544"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.697516"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aat5690"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2016.02.001"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15756"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12113332"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S238099"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf800175a"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015976430790"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature22341"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-001-0376-4"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2016.55"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2018.05.020"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(02)02103-3"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b14577"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0250-9"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.3402\/jev.v3.24641"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/nl061412u"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c02404"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-017-0012-z"},{"key":"e_1_3_4_33_1","first-page":"1000164","article-title":"Paclitaxel nano-delivery systems: a comprehensive review","volume":"4","author":"Ping M","year":"2013","unstructured":"Ping M, Mumper RJ. (2013). Paclitaxel nano-delivery systems: a comprehensive review. J Nanomed Nanotechnol 4:1000164.","journal-title":"J Nanomed Nanotechnol"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17081296"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R084343"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.08.034"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201506154"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-3410"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.15.118"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1830"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2021.1951894"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41578-020-00277-6"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2013.08.004"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.03.039"},{"key":"e_1_3_4_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11718-4"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.8b00379"},{"key":"e_1_3_4_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.119849"},{"key":"e_1_3_4_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.08.021"}],"container-title":["Drug Delivery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/10717544.2021.2023697","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/full-xml\/10.1080\/10717544.2021.2023697","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/10717544.2021.2023697","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T11:16:13Z","timestamp":1787570173000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/10717544.2021.2023697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,5]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12,31]]}},"alternative-id":["10.1080\/10717544.2021.2023697"],"URL":"https:\/\/doi.org\/10.1080\/10717544.2021.2023697","relation":{},"ISSN":["1071-7544","1521-0464"],"issn-type":[{"value":"1071-7544","type":"print"},{"value":"1521-0464","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,5]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=idrd20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=idrd20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2021-10-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-15","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}