{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:05:05Z","timestamp":1789416305047,"version":"build-2803163510"},"reference-count":73,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T00:00:00Z","timestamp":1672876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Drug Delivery"],"published-print":{"date-parts":[[2023,12,31]]},"DOI":"10.1080\/10717544.2022.2162159","type":"journal-article","created":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T00:26:30Z","timestamp":1672964790000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":47,"title":["Syringeable atorvastatin loaded eugenol enriched PEGylated cubosomes in-situ gel for the intra-pocket treatment of periodontitis: statistical optimization and clinical assessment"],"prefix":"10.1080","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9610-8654","authenticated-orcid":false,"given":"Heba Amin","family":"Elgendy","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology","place":["Giza, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2580-8722","authenticated-orcid":false,"given":"Amna M. A.","family":"Makky","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University","place":["Cairo, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7648-6831","authenticated-orcid":false,"given":"Yara E.","family":"Elakkad","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology","place":["Giza, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0128-6042","authenticated-orcid":false,"given":"Radwa M.","family":"Ismail","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Periodontology and Oral Diagnosis, Faculty of Dentistry, Misr University for Science and Technology","place":["Giza, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5105-3669","authenticated-orcid":false,"given":"Nihal Farid","family":"Younes","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University","place":["Cairo, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,1,5]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2018.1477858"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/1119-3077.183306"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2019.04.014"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S316326"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2020.1859000"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2014.06.041"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11694-019-00170-z"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-021-01607-y"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.130018"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jobcr.2017.12.005"},{"key":"e_1_3_4_12_1","unstructured":"British Pharmacopoeia Commission. (2011). British pharmacopoeia 2011. The Department Of Health. Social Services and Public Safety."},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.20843"},{"key":"e_1_3_4_14_1","doi-asserted-by":"crossref","unstructured":"Carter HG Barnes P. (1974). The Gingival Bleeding Index. J Periodontol 45(11):801\u2013805.","DOI":"10.1902\/jop.1974.45.11.801"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-019-1513-x"},{"key":"e_1_3_4_16_1","first-page":"815981","article-title":"Cubic and hexagonal liquid crystals as drug delivery systems","volume":"2014","author":"Chen Y","year":"2014","unstructured":"Chen Y, Ma P, Gui S. (2014). Cubic and hexagonal liquid crystals as drug delivery systems. Biomed Res Int 2014:815981.","journal-title":"Biomed Res Int"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2012.05.002"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/1947-2714.112473"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajps.2018.08.010"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.120269"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.120483"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2019.04.036"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/03639045.2017.1391836"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S87336"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/10837450.2020.1765180"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000102939.04279.75"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-017-0341-1"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-020-02857-1"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2017.1329297"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.5455\/oams.310516.rv.024"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1992.tb00670.x"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2019.118684"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-013-0171-x"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S337130"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-017-0763-8"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1081\/DDC-120028715"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S38203"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-74845-9"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sdentj.2018.06.001"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.farmac.2005.04.014"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.11637\/kjpa.2015.28.1.45"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/jicd.12213"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717540590952555"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2020.111534"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2017.1359703"},{"key":"e_1_3_4_46_1","article-title":"Antiproliferative effect of topic hyaluronic acid gel","author":"Mesa FL","year":"2002","unstructured":"Mesa FL, Aneiros J, Cabrera A, et\u00a0al. (2002). Antiproliferative effect of topic hyaluronic acid gel. Histol Histopathol 17(3):747\u201353.","journal-title":"Histol Histopathol 17(3):747\u201353."},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2021.02.007"},{"key":"e_1_3_4_48_1","unstructured":"Moore JW Flanner HH. (1996). Mathematical comparison of curves with an emphasis on in vitro release profiles. Pharm Tech 20(6):64\u201374."},{"key":"e_1_3_4_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2016.04.021"},{"key":"e_1_3_4_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2019.1571121"},{"key":"e_1_3_4_51_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2022.2075985"},{"key":"e_1_3_4_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-020-00785-6"},{"key":"e_1_3_4_53_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2016.1233591"},{"key":"e_1_3_4_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2018.09.002"},{"key":"e_1_3_4_55_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567201817666200608145748"},{"key":"e_1_3_4_56_1","doi-asserted-by":"crossref","unstructured":"Opdyke DLJ. (1975). MONOGRAPHS monographs on fragrance raw materials*. Food Chem Toxicol 13:815\u201317.","DOI":"10.1016\/0015-6264(75)90012-7"},{"key":"e_1_3_4_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00137"},{"key":"e_1_3_4_58_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.120393"},{"key":"e_1_3_4_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2021.111945"},{"key":"e_1_3_4_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2019.03.034"},{"key":"e_1_3_4_61_1","doi-asserted-by":"publisher","DOI":"10.3109\/10717544.2014.929195"},{"key":"e_1_3_4_62_1","doi-asserted-by":"publisher","DOI":"10.1080\/08982104.2020.1867166"},{"key":"e_1_3_4_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-019-00698-z"},{"key":"e_1_3_4_64_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-020-01807-9"},{"key":"e_1_3_4_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2020.113816"},{"key":"e_1_3_4_66_1","doi-asserted-by":"publisher","DOI":"10.3109\/10717544.2014.907842"},{"key":"e_1_3_4_67_1","doi-asserted-by":"publisher","DOI":"10.1515\/dmpt-2015-0024"},{"key":"e_1_3_4_68_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-020-02326-8"},{"key":"e_1_3_4_69_1","first-page":"ZC13","article-title":"Changes in transforming growth factor-\u03b21 in gingival crevicular fluid of patients with chronic periodontitis following periodontal flap surgery","volume":"9","author":"Vikram V","year":"2015","unstructured":"Vikram V, Ramakrishnan T, Anilkumar K, Ambalavanan N. (2015). Changes in transforming growth factor-\u03b21 in gingival crevicular fluid of patients with chronic periodontitis following periodontal flap surgery. J Clin Diagn Res 9:ZC13\u2013ZC16.","journal-title":"J Clin Diagn Res"},{"key":"e_1_3_4_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2016.04.059"},{"key":"e_1_3_4_71_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2018.1497107"},{"key":"e_1_3_4_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2018.10.057"},{"key":"e_1_3_4_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-019-00706-2"},{"key":"e_1_3_4_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2022.103364"}],"container-title":["Drug Delivery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/10717544.2022.2162159","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T10:26:37Z","timestamp":1780914397000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/10717544.2022.2162159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,5]]},"references-count":73,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,12,31]]}},"alternative-id":["10.1080\/10717544.2022.2162159"],"URL":"https:\/\/doi.org\/10.1080\/10717544.2022.2162159","relation":{},"ISSN":["1071-7544","1521-0464"],"issn-type":[{"value":"1071-7544","type":"print"},{"value":"1521-0464","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,5]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=idrd20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=idrd20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2022-10-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-18","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2162159"}}