{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:56:41Z","timestamp":1792785401318,"version":"4.5.0"},"reference-count":34,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020140","name":"Amsterdam Neuroscience","doi-asserted-by":"publisher","award":["NDIS-2019-03"],"award-info":[{"award-number":["NDIS-2019-03"]}],"id":[{"id":"10.13039\/501100020140","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union\u2019s Horizon 2020 research and innovation program","award":["777072"],"award-info":[{"award-number":["777072"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Drug Delivery"],"published-print":{"date-parts":[[2023,12,31]]},"DOI":"10.1080\/10717544.2023.2194579","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T04:02:40Z","timestamp":1680148960000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":10,"title":["Extravasation of biodegradable microspheres in the rat brain"],"prefix":"10.1080","volume":"30","author":[{"given":"Anne-Eva","family":"van der Wijk","sequence":"first","affiliation":[{"name":"Deparment of Biomedical Engineering and Physics, Amsterdam UMC Location University of Amsterdam","place":["Amsterdam, The Netherlands"]},{"name":"Neurovascular Disorders Program, Amsterdam Neuroscience","place":["The Netherlands"]},{"name":"Microcirculation Program, Amsterdam Cardiovascular Sciences","place":["Amsterdam, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodosia","family":"Georgakopoulou","sequence":"additional","affiliation":[{"name":"Deparment of Biomedical Engineering and Physics, Amsterdam UMC Location University of Amsterdam","place":["Amsterdam, The Netherlands"]},{"name":"Neurovascular Disorders Program, Amsterdam Neuroscience","place":["The Netherlands"]},{"name":"Microcirculation Program, Amsterdam Cardiovascular Sciences","place":["Amsterdam, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Steendam","sequence":"additional","affiliation":[{"name":"InnoCore Pharmaceuticals","place":["Groningen, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Zuidema","sequence":"additional","affiliation":[{"name":"InnoCore Pharmaceuticals","place":["Groningen, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter L.","family":"Hordijk","sequence":"additional","affiliation":[{"name":"Neurovascular Disorders Program, Amsterdam Neuroscience","place":["The Netherlands"]},{"name":"Microcirculation Program, Amsterdam Cardiovascular Sciences","place":["Amsterdam, The Netherlands"]},{"name":"Deparment of Physiology, Amsterdam UMC Location Vrije Universiteit Amsterdam","place":["Amsterdam, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik N.T.P.","family":"Bakker","sequence":"additional","affiliation":[{"name":"Deparment of Biomedical Engineering and Physics, Amsterdam UMC Location University of Amsterdam","place":["Amsterdam, The Netherlands"]},{"name":"Neurovascular Disorders Program, Amsterdam Neuroscience","place":["The Netherlands"]},{"name":"Microcirculation Program, Amsterdam Cardiovascular Sciences","place":["Amsterdam, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ed","family":"van Bavel","sequence":"additional","affiliation":[{"name":"Deparment of Biomedical Engineering and Physics, Amsterdam UMC Location University of Amsterdam","place":["Amsterdam, The Netherlands"]},{"name":"Neurovascular Disorders Program, Amsterdam Neuroscience","place":["The Netherlands"]},{"name":"Microcirculation Program, Amsterdam Cardiovascular Sciences","place":["Amsterdam, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,3,30]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.07.030"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-016-0087-5"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.06.011"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-3659(99)00170-4"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd10020086"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3426"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf6086"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-19887"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.12491"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2021.105739"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-018-0849-8"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006585"},{"key":"e_1_3_4_14_1","unstructured":"Hughes P Rivers H Shen J et\u00a0al. Poly-dioxanone multi-block copolymer for ocular protein delivery. World Intellectual Property Organization International publication number WO2021\/067388 2021. Available at: https:\/\/nl.espacenet.com [last accessed 14 September 2022]."},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-015-0319-6"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09001"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04315-4"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1333648"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI25410"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1163\/156856209X429175"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)00067-3"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2009.10.026"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2020.11.008"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/neurintsurg-2021-017321"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1602\/neurorx.2.1.3"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.8b00116"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature19323"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3278"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2014.02.012"},{"key":"e_1_3_4_30_1","unstructured":"Steendam R Coimbra M Ribeiro Arauja JC Zuidema J Henzler T Krog A. Dosage form for extended release of an antibody or large protein. European patent office European patent application EP4051233 published September 7 2022. Available at https:\/\/nl.espacenet.com. 2022."},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2017.09.072"},{"key":"e_1_3_4_32_1","unstructured":"U.S. Food & Drug Administration (FDA). (2021). Availableat: https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-grants-accelerated-approval-alzheimers-drug."},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-020-01071-9"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.024975"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-015-1700-8"}],"container-title":["Drug Delivery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/10717544.2023.2194579","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T10:27:14Z","timestamp":1780914434000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/10717544.2023.2194579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,30]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,12,31]]}},"alternative-id":["10.1080\/10717544.2023.2194579"],"URL":"https:\/\/doi.org\/10.1080\/10717544.2023.2194579","relation":{},"ISSN":["1071-7544","1521-0464"],"issn-type":[{"value":"1071-7544","type":"print"},{"value":"1521-0464","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,30]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=idrd20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=idrd20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2022-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-09","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2194579"}}