{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T01:19:30Z","timestamp":1790558370774,"version":"4.1.0"},"reference-count":67,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T00:00:00Z","timestamp":1744329600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Drug Delivery"],"published-print":{"date-parts":[[2025,12,31]]},"DOI":"10.1080\/10717544.2025.2484277","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T05:22:17Z","timestamp":1744348937000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":6,"title":["Ketorolac, melatonin and latanoprost tri-loaded PLGA microspheres for neuroprotection in glaucoma"],"prefix":"10.1080","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6694-9700","authenticated-orcid":false,"given":"Miriam","family":"Ana Gonz\u00e1lez-Cela-Casamayor","sequence":"first","affiliation":[{"name":"Innovation, Therapy and Pharmaceutical Development in Ophthalmology (InnOftal) Research Group, UCM 920415, Department of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University of Madrid","place":["Madrid, Spain"]},{"name":"Health Research Institute, San Carlos Clinical Hospital (IdISSC)","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4009-3075","authenticated-orcid":false,"given":"Mar\u00eda J.","family":"Rodrigo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Miguel Servet University Hospital","place":["Zaragoza, Spain"]},{"name":"Miguel Servet Ophthalmology Research Group (GIMSO), Aragon Health Research Institute (IIS Aragon), University of Zaragoza","place":["Zaragoza, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2600-6446","authenticated-orcid":false,"given":"Marco","family":"Brugnera","sequence":"additional","affiliation":[{"name":"Innovation, Therapy and Pharmaceutical Development in Ophthalmology (InnOftal) Research Group, UCM 920415, Department of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University of Madrid","place":["Madrid, Spain"]},{"name":"Health Research Institute, San Carlos Clinical Hospital (IdISSC)","place":["Madrid, Spain"]},{"name":"School of Pharmacy, University Institute for Industrial Pharmacy (IUFI), Complutense University of Madrid","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1502-641X","authenticated-orcid":false,"given":"In\u00e9s","family":"Munuera","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Miguel Servet University Hospital","place":["Zaragoza, Spain"]},{"name":"Miguel Servet Ophthalmology Research Group (GIMSO), Aragon Health Research Institute (IIS Aragon), University of Zaragoza","place":["Zaragoza, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8891-0417","authenticated-orcid":false,"given":"Teresa","family":"Mart\u00ednez-Rinc\u00f3n","sequence":"additional","affiliation":[{"name":"Miguel Servet Ophthalmology Research Group (GIMSO), Aragon Health Research Institute (IIS Aragon), University of Zaragoza","place":["Zaragoza, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"Prats-Llu\u00eds","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Faculty of Medicine and Health Sciences, University of Barcelona and Bellvitge Biomedical Research Institute (IDIBELL)","place":["l\u2019Hospitalet de Llobregat, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2860-7475","authenticated-orcid":false,"given":"Pilar","family":"Villacampa","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, Faculty of Medicine and Health Sciences, University of Barcelona and Bellvitge Biomedical Research Institute (IDIBELL)","place":["l\u2019Hospitalet de Llobregat, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7772-5718","authenticated-orcid":false,"given":"Juli\u00e1n","family":"Garc\u00eda-Feijoo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, San Carlos Clinical Hospital, Health Research Institute of the San Carlos Clinical Hospital (IdISSC)","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2389-8282","authenticated-orcid":false,"given":"Luis E.","family":"Pablo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Miguel Servet University Hospital","place":["Zaragoza, Spain"]},{"name":"Miguel Servet Ophthalmology Research Group (GIMSO), Aragon Health Research Institute (IIS Aragon), University of Zaragoza","place":["Zaragoza, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3133-7872","authenticated-orcid":false,"given":"Irene","family":"Bravo-Osuna","sequence":"additional","affiliation":[{"name":"Innovation, Therapy and Pharmaceutical Development in Ophthalmology (InnOftal) Research Group, UCM 920415, Department of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University of Madrid","place":["Madrid, Spain"]},{"name":"Health Research Institute, San Carlos Clinical Hospital (IdISSC)","place":["Madrid, Spain"]},{"name":"School of Pharmacy, University Institute for Industrial Pharmacy (IUFI), Complutense University of Madrid","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6258-2489","authenticated-orcid":false,"given":"Elena","family":"Garcia-Martin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Miguel Servet University Hospital","place":["Zaragoza, Spain"]},{"name":"Miguel Servet Ophthalmology Research Group (GIMSO), Aragon Health Research Institute (IIS Aragon), University of Zaragoza","place":["Zaragoza, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9764-7975","authenticated-orcid":false,"given":"Roc\u00edo","family":"Herrero-Vanrell","sequence":"additional","affiliation":[{"name":"Innovation, Therapy and Pharmaceutical Development in Ophthalmology (InnOftal) Research Group, UCM 920415, Department of Pharmaceutics and Food Technology, Faculty of Pharmacy, Complutense University of Madrid","place":["Madrid, Spain"]},{"name":"Health Research Institute, San Carlos Clinical Hospital (IdISSC)","place":["Madrid, Spain"]},{"name":"School of Pharmacy, University Institute for Industrial Pharmacy (IUFI), Complutense University of Madrid","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,4,11]]},"reference":[{"key":"e_1_3_6_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874364101408010067"},{"key":"e_1_3_6_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.245465"},{"key":"e_1_3_6_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-620X.200692"},{"key":"e_1_3_6_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S59162"},{"key":"e_1_3_6_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2022.2096712"},{"key":"e_1_3_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.01.012"},{"key":"e_1_3_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-021-00930-9"},{"key":"e_1_3_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2019.05.070"},{"key":"e_1_3_6_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13020228"},{"key":"e_1_3_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(02)00400-9"},{"key":"e_1_3_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(03)00408-8"},{"key":"e_1_3_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-004-0155-x"},{"key":"e_1_3_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2010.00762.x"},{"key":"e_1_3_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2020.108222"},{"key":"e_1_3_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.12.053"},{"key":"e_1_3_6_17_1","doi-asserted-by":"publisher","DOI":"10.1079\/9781780644479.0160"},{"key":"e_1_3_6_18_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14.10.1307"},{"key":"e_1_3_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.01.007"},{"key":"e_1_3_6_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14020288"},{"key":"e_1_3_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2011.06.023"},{"key":"e_1_3_6_22_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200767050-00006"},{"key":"e_1_3_6_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/02713680802100845"},{"key":"e_1_3_6_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21239267"},{"key":"e_1_3_6_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.2000.03288.x"},{"key":"e_1_3_6_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fddev.2022.954771"},{"key":"e_1_3_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2024.102389"},{"key":"e_1_3_6_28_1","doi-asserted-by":"publisher","DOI":"10.3109\/13816810.2016.1164193"},{"key":"e_1_3_6_29_1","doi-asserted-by":"publisher","DOI":"10.1006\/exer.2000.0975"},{"key":"e_1_3_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2017.02.037"},{"key":"e_1_3_6_31_1","first-page":"733","article-title":"Photoreceptor preservation induced by intravitreal controlled delivery of GDNF and GDNF\/melatonin in rhodopsin knockout mice","volume":"24","author":"Garc\u00eda-Caballero C.","year":"2018","unstructured":"Garc\u00eda-Caballero, C., et\u00a0al., 2018. Photoreceptor preservation induced by intravitreal controlled delivery of GDNF and GDNF\/melatonin in rhodopsin knockout mice. Molecular vision, 24 (November), 733\u2013745.","journal-title":"Molecular vision"},{"key":"e_1_3_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/sstr.202400484"},{"key":"e_1_3_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.07.026"},{"key":"e_1_3_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2014.04.002"},{"key":"e_1_3_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2017.08.011"},{"key":"e_1_3_6_36_1","doi-asserted-by":"crossref","unstructured":"L\u00f3pez-Cano J.L. et\u00a0al. 2021. Thermo-responsive PLGA-PEG-PLGA hydrogels as novel injectable platforms for neuroprotective combined therapies in the treatment of retinal degenerative diseases. Pharmaceutics 13(2) 234.","DOI":"10.3390\/pharmaceutics13020234"},{"key":"e_1_3_6_37_1","first-page":"1783","article-title":"Intravitreal injections of GDNF-loaded biodegradable microspheres are neuroprotective in a rat model of glaucoma","volume":"13","author":"Jiang C.","year":"2007","unstructured":"Jiang, C., et\u00a0al., 2007. Intravitreal injections of GDNF-loaded biodegradable microspheres are neuroprotective in a rat model of glaucoma. Molecular vision, 13, 1783\u20131792.","journal-title":"Molecular vision"},{"key":"e_1_3_6_38_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3528274"},{"key":"e_1_3_6_39_1","unstructured":"Jukarainen H. J. et\u00a0al. 2024. Safety tolerability & pharmacokinetics of sustained release Latanoprost (LAT) from intravitreal injection of a semi-solid in-situ forming implant. Investigative Ophthalmology & Visual Science 65 3981."},{"key":"e_1_3_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2008.11.012"},{"key":"e_1_3_6_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-005-0215-0"},{"key":"e_1_3_6_42_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728214.2011.521631"},{"key":"e_1_3_6_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym3031377"},{"key":"e_1_3_6_44_1","doi-asserted-by":"publisher","DOI":"10.1556\/AChrom.26.2014.2.1"},{"key":"e_1_3_6_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-017-0768-z"},{"key":"e_1_3_6_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-019-01163-6"},{"key":"e_1_3_6_47_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/5901537"},{"key":"e_1_3_6_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12080706"},{"key":"e_1_3_6_49_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-18213"},{"key":"e_1_3_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2020.04.055"},{"key":"e_1_3_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.119475"},{"key":"e_1_3_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2020.102086"},{"key":"e_1_3_6_53_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S151437"},{"key":"e_1_3_6_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12360"},{"key":"e_1_3_6_55_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3192"},{"key":"e_1_3_6_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2023.109736"},{"key":"e_1_3_6_57_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713688809033192"},{"key":"e_1_3_6_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-020-00769-8"},{"key":"e_1_3_6_59_1","doi-asserted-by":"publisher","DOI":"10.1080\/08820538.2021.1985145"},{"key":"e_1_3_6_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-018-4058-x"},{"key":"e_1_3_6_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2007.03.024"},{"key":"e_1_3_6_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29716"},{"key":"e_1_3_6_63_1","doi-asserted-by":"publisher","DOI":"10.1159\/000333822"},{"key":"e_1_3_6_64_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-021-00611-y"},{"key":"e_1_3_6_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12428"},{"key":"e_1_3_6_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13902"},{"key":"e_1_3_6_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12828"},{"key":"e_1_3_6_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.09.029"}],"container-title":["Drug Delivery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/10717544.2025.2484277","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T14:30:35Z","timestamp":1766068235000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/10717544.2025.2484277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,11]]},"references-count":67,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12,31]]}},"alternative-id":["10.1080\/10717544.2025.2484277"],"URL":"https:\/\/doi.org\/10.1080\/10717544.2025.2484277","relation":{},"ISSN":["1071-7544","1521-0464"],"issn-type":[{"value":"1071-7544","type":"print"},{"value":"1521-0464","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,11]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=idrd20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=idrd20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2024-12-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-17","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2484277"}}