{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T16:20:28Z","timestamp":1788970828778,"version":"build-2803163510"},"reference-count":52,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019000","name":"Medical Affairs Bureau","doi-asserted-by":"publisher","award":["MAB-D-111145"],"award-info":[{"award-number":["MAB-D-111145"]}],"id":[{"id":"10.13039\/501100019000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC113-2314-B-016-011-MY3, NSTC112-2221-E-011-026-MY3, NSTC110-2314-B-016-047-MY3"],"award-info":[{"award-number":["NSTC113-2314-B-016-011-MY3, NSTC112-2221-E-011-026-MY3, NSTC110-2314-B-016-047-MY3"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007530","name":"National Taiwan University of Science and Technology","doi-asserted-by":"publisher","award":["NTUST-TSGH-114-01"],"award-info":[{"award-number":["NTUST-TSGH-114-01"]}],"id":[{"id":"10.13039\/501100007530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010425","name":"Tri-Service General Hospital","doi-asserted-by":"publisher","award":["TSGH-A-114001"],"award-info":[{"award-number":["TSGH-A-114001"]}],"id":[{"id":"10.13039\/501100010425","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Drug Delivery"],"published-print":{"date-parts":[[2025,12,31]]},"DOI":"10.1080\/10717544.2025.2576220","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T05:49:30Z","timestamp":1762408170000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":2,"title":["Transcranial ultrasound combined with intravenous metformin-loaded oxygenated microbubbles attenuates noise-induced hearing loss in mice"],"prefix":"10.1080","volume":"32","author":[{"given":"Ai-Ho","family":"Liao","sequence":"first","affiliation":[{"name":"Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology","place":["Taipei, Taiwan"]},{"name":"Department of Biomedical Engineering, National Defense Medical University","place":["Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Hung","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Taipei City Hospital","place":["Taipei, Taiwan"]},{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical University","place":["Taipei, Taiwan"]},{"name":"Graduate Institute of Medical Sciences, National Defense Medical University","place":["Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin-Yi","family":"Chou","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology","place":["Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chan","family":"Hung","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology","place":["Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chun","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical University","place":["Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho-Chiao","family":"Chuang","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, National Taipei University of Technology","place":["Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Hsing","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Biology and Anatomy, National Defense Medical University","place":["Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Li","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Electrical Engineering, National Taiwan University","place":["Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jehng-Kang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, National Defense Medical University","place":["Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Ping","family":"Shih","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical University","place":["Taipei, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,11,5]]},"reference":[{"key":"e_1_3_6_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00155"},{"key":"e_1_3_6_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.1c00587"},{"key":"e_1_3_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599819859885"},{"key":"e_1_3_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-013-0431-y"},{"key":"e_1_3_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1479164119826292"},{"key":"e_1_3_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2019.102328"},{"key":"e_1_3_6_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3213-07.2008"},{"key":"e_1_3_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.01.034"},{"key":"e_1_3_6_10_1","first-page":"1124","article-title":"Biomaterials based on noncovalent interactions of small molecules","volume":"19","author":"Guo J","year":"2020","unstructured":"Guo J, Tian C, Xu B. 2020. Biomaterials based on noncovalent interactions of small molecules. EXCLI J. 19:1124\u20131140.","journal-title":"EXCLI J"},{"key":"e_1_3_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.06.043"},{"key":"e_1_3_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202212919"},{"key":"e_1_3_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.03.018"},{"key":"e_1_3_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2016.02.019"},{"key":"e_1_3_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000004002"},{"issue":"12","key":"e_1_3_6_16_1","first-page":"66","volume":"275","author":"Kesici GG","year":"2018","unstructured":"Kesici GG, \u00d6cal FCA, G\u00fcrgen SG. The protective effect of metformin against the noise-induced hearing loss. Eur Arch Otorhinolaryngol. 2018;275(12):66\u20132957.","journal-title":"The protective effect of metformin against the noise-induced hearing loss. Eur Arch Otorhinolaryngol"},{"key":"e_1_3_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.05.072"},{"key":"e_1_3_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10479"},{"key":"e_1_3_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2025.111214"},{"key":"e_1_3_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(00)00005-8"},{"key":"e_1_3_6_21_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00417.2020"},{"key":"e_1_3_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-26702-z"},{"key":"e_1_3_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep41325"},{"key":"e_1_3_6_24_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.14932"},{"key":"e_1_3_6_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0232617"},{"key":"e_1_3_6_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.668754"},{"key":"e_1_3_6_27_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.132880"},{"key":"e_1_3_6_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e32833da3c3"},{"key":"e_1_3_6_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.689032"},{"key":"e_1_3_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(03)00134-5"},{"key":"e_1_3_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2023.115145"},{"key":"e_1_3_6_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200505310-00004"},{"key":"e_1_3_6_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1549-6"},{"key":"e_1_3_6_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aao0935"},{"key":"e_1_3_6_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000013845"},{"key":"e_1_3_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2015.05.004"},{"key":"e_1_3_6_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16081121"},{"issue":"1","key":"e_1_3_6_38_1","first-page":"16","article-title":"Too much oxygen: hyperoxia and oxygen management in mechanically ventilated patients","volume":"7","author":"Pannu SR","year":"2016","unstructured":"Pannu SR. 2016. Too much oxygen: hyperoxia and oxygen management in mechanically ventilated patients. Semin Respir Crit Care Med. 7(1):16\u201322.","journal-title":"Semin Respir Crit Care Med"},{"key":"e_1_3_6_39_1","doi-asserted-by":"publisher","DOI":"10.7150\/ntno.90516"},{"key":"e_1_3_6_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2014.893540"},{"key":"e_1_3_6_41_1","doi-asserted-by":"publisher","DOI":"10.7150\/ntno.43808"},{"key":"e_1_3_6_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb08644.x"},{"key":"e_1_3_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2013.01.028"},{"key":"e_1_3_6_44_1","doi-asserted-by":"publisher","DOI":"10.1177\/0267659114534290"},{"key":"e_1_3_6_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.34839"},{"key":"e_1_3_6_46_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200212200-00017"},{"key":"e_1_3_6_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.232"},{"key":"e_1_3_6_48_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0BM01931C"},{"key":"e_1_3_6_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-021-03468-x"},{"key":"e_1_3_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2017.08.1883"},{"key":"e_1_3_6_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-022-03077-x"},{"key":"e_1_3_6_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c08088"},{"key":"e_1_3_6_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.06.058"}],"container-title":["Drug Delivery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/10717544.2025.2576220","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T14:30:24Z","timestamp":1766068224000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/10717544.2025.2576220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,5]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,12,31]]}},"alternative-id":["10.1080\/10717544.2025.2576220"],"URL":"https:\/\/doi.org\/10.1080\/10717544.2025.2576220","relation":{},"ISSN":["1071-7544","1521-0464"],"issn-type":[{"value":"1071-7544","type":"print"},{"value":"1521-0464","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,5]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=idrd20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=idrd20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2025-07-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-22","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2576220"}}