{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T15:24:45Z","timestamp":1794410685380,"version":"4.9.0"},"reference-count":69,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Agencia Estatal de Investigaci\u00f3n - Spain","award":["CPP2021-008597, RED2022-134287-T"],"award-info":[{"award-number":["CPP2021-008597, RED2022-134287-T"]}]},{"name":"JJCC Castilla-La Mancha","award":["JCCM SBPLY\/21\/180501\/000188"],"award-info":[{"award-number":["JCCM SBPLY\/21\/180501\/000188"]}]},{"name":"insitituto de Salud Carlos III","award":["PT20\/00161, PT23\/00077"],"award-info":[{"award-number":["PT20\/00161, PT23\/00077"]}]},{"name":"Universidad de Castilla-La Mancha and JCCM","award":["SBPLY\/21\/180501\/000050"],"award-info":[{"award-number":["SBPLY\/21\/180501\/000050"]}]},{"name":"Agencia de Ciencia, Competitividad Empresarial e Innovaci\u00f3n del Principado de Asturias","award":["IDE\/2024\/000741"],"award-info":[{"award-number":["IDE\/2024\/000741"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Drug Delivery"],"published-print":{"date-parts":[[2026,12,31]]},"DOI":"10.1080\/10717544.2026.2671485","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T05:16:15Z","timestamp":1778562975000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":1,"title":["Liposome-mediated delivery of a ruthenium-based metallodrug to overcome cisplatin resistance in osteosarcoma"],"prefix":"10.1080","volume":"33","author":[{"given":"Dzohara","family":"Murillo","sequence":"first","affiliation":[{"name":"Sarcomas and Experimental Therapeutics, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA)","place":["Oviedo, Spain"]},{"name":"Instituto Universitario de Oncolog\u00eda del Principado de Asturias (IUOPA)","place":["Oviedo, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Dom\u00ednguez-Jurado","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Inorg\u00e1nica, Org\u00e1nica y Bioqu\u00edmica-Centro de Innovaci\u00f3n en Qu\u00edmica Avanzada (ORFEO-CINQA), Unidad nanoDrug, Facultad de Farmacia de Albacete, Universidad de Castilla-La Mancha","place":["Albacete, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Huergo","sequence":"additional","affiliation":[{"name":"Sarcomas and Experimental Therapeutics, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA)","place":["Oviedo, Spain"]},{"name":"Instituto Universitario de Oncolog\u00eda del Principado de Asturias (IUOPA)","place":["Oviedo, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borja","family":"Gallego","sequence":"additional","affiliation":[{"name":"Sarcomas and Experimental Therapeutics, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA)","place":["Oviedo, Spain"]},{"name":"Instituto Universitario de Oncolog\u00eda del Principado de Asturias (IUOPA)","place":["Oviedo, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"D\u00edez","sequence":"additional","affiliation":[{"name":"Sarcomas and Experimental Therapeutics, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA)","place":["Oviedo, Spain"]},{"name":"Instituto Universitario de Oncolog\u00eda del Principado de Asturias (IUOPA)","place":["Oviedo, Spain"]},{"name":"Departamento de Biolog\u00eda Funcional, \u00c1rea de Inmunolog\u00eda, Facultad de Medicina y Ciencias de la Salud, Universidad de Oviedo","place":["Oviedo, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Ferreras","sequence":"additional","affiliation":[{"name":"Sarcomas and Experimental Therapeutics, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA)","place":["Oviedo, Spain"]},{"name":"Instituto Universitario de Oncolog\u00eda del Principado de Asturias (IUOPA)","place":["Oviedo, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enol","family":"\u00c1lvarez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Sarcomas and Experimental Therapeutics, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA)","place":["Oviedo, Spain"]},{"name":"Instituto Universitario de Oncolog\u00eda del Principado de Asturias (IUOPA)","place":["Oviedo, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Rey","sequence":"additional","affiliation":[{"name":"Sarcomas and Experimental Therapeutics, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA)","place":["Oviedo, Spain"]},{"name":"Instituto Universitario de Oncolog\u00eda del Principado de Asturias (IUOPA)","place":["Oviedo, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar","family":"Rodr\u00edguez\u2011Santamar\u00eda","sequence":"additional","affiliation":[{"name":"Sarcomas and Experimental Therapeutics, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA)","place":["Oviedo, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana S.","family":"Indurain","sequence":"additional","affiliation":[{"name":"Sarcomas and Experimental Therapeutics, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA)","place":["Oviedo, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"de Andr\u00e9s Segura","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Anal\u00edtica y Tecnolog\u00eda de Alimentos, Facultad de Farmacia de Albacete, Universidad de Castilla-La Mancha","place":["Albacete, Spain"]},{"name":"Universidad de Castilla-La Mancha, Instituto Regional de Investigaci\u00f3n Cient\u00edfica Aplicada IRICA","place":["Ciudad Real, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iv\u00e1n","family":"Bravo","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica F\u00edsica, Unidad nanoDrug, Facultad de Farmacia de Albacete, Universidad de Castilla-La Mancha","place":["Albacete, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel","family":"R\u00edos","sequence":"additional","affiliation":[{"name":"Universidad de Castilla-La Mancha, Instituto Regional de Investigaci\u00f3n Cient\u00edfica Aplicada IRICA","place":["Ciudad Real, Spain"]},{"name":"Departamento de Qu\u00edmica Anal\u00edtica y Tecnolog\u00eda de Alimentos, Facultad de Ciencias y Tecnolog\u00edas Qu\u00edmicas, Universidad de Castilla-La Mancha","place":["Ciudad Real, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adela A.","family":"Fern\u00e1ndez-Velasco","sequence":"additional","affiliation":[{"name":"Sarcomas and Experimental Therapeutics, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA)","place":["Oviedo, Spain"]},{"name":"Instituto Universitario de Oncolog\u00eda del Principado de Asturias (IUOPA)","place":["Oviedo, Spain"]},{"name":"Biobanco del Principado de Asturias","place":["Oviedo, Spain"]},{"name":"Servicio de Patolog\u00eda, Hospital Universitario Central de Asturias","place":["Oviedo, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iv\u00e1n","family":"Fern\u00e1ndez-Vega","sequence":"additional","affiliation":[{"name":"Sarcomas and Experimental Therapeutics, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA)","place":["Oviedo, Spain"]},{"name":"Instituto Universitario de Oncolog\u00eda del Principado de Asturias (IUOPA)","place":["Oviedo, Spain"]},{"name":"Biobanco del Principado de Asturias","place":["Oviedo, Spain"]},{"name":"Servicio de Patolog\u00eda, Hospital Universitario Central de Asturias","place":["Oviedo, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7588-0781","authenticated-orcid":false,"given":"Carlos","family":"Alonso-Moreno","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Inorg\u00e1nica, Org\u00e1nica y Bioqu\u00edmica-Centro de Innovaci\u00f3n en Qu\u00edmica Avanzada (ORFEO-CINQA), Unidad nanoDrug, Facultad de Farmacia de Albacete, Universidad de Castilla-La Mancha","place":["Albacete, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0768-7306","authenticated-orcid":false,"given":"Ren\u00e9","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Sarcomas and Experimental Therapeutics, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA)","place":["Oviedo, Spain"]},{"name":"Instituto Universitario de Oncolog\u00eda del Principado de Asturias (IUOPA)","place":["Oviedo, Spain"]},{"name":"Instituto de Biomedicina y Biotecnologia de Cantabria (IBBTEC), CSIC-UC-SODERCAN","place":["Santander, Spain"]},{"name":"CIBER en oncolog\u00eda (CIBERONC)","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3631764"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-023-02931-7"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-328X(02)01926-5"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.09.037"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2025.118352"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2023.215169"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/c7dt03369a"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.7b04092"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2024.122945"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.06.027"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.9b00296"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16121729"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.07.025"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.117165"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13101559"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2024.216252"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201300379"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-021-01008-x"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114627"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3MD00367A"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2018.09.047"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076473"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076615"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23126425"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11671-021-03628-6"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.120438"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.120571"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2018-0236"},{"key":"e_1_3_5_30_1","volume-title":"Bone cancer \u2013 bone sarcomas and bone metastasis \u2013 from bench to bedside","author":"Heymann D","year":"2021","unstructured":"Heymann D. 2021. Bone cancer \u2013 bone sarcomas and bone metastasis \u2013 from bench to bedside. 3rd ed. Academic Press.","edition":"3"},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2016.05.005"},{"key":"e_1_3_5_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep45236"},{"key":"e_1_3_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70062-0"},{"key":"e_1_3_5_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/d5dt01704a"},{"key":"e_1_3_5_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14184474"},{"key":"e_1_3_5_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2024.216118"},{"key":"e_1_3_5_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c02006"},{"key":"e_1_3_5_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2018.04.016"},{"key":"e_1_3_5_39_1","doi-asserted-by":"publisher","DOI":"10.3109\/1061186X.2015.1051049"},{"key":"e_1_3_5_40_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S275007"},{"key":"e_1_3_5_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202310636"},{"key":"e_1_3_5_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/inorganics13070246"},{"key":"e_1_3_5_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep27878"},{"key":"e_1_3_5_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2017.03.004"},{"key":"e_1_3_5_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12040964"},{"key":"e_1_3_5_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10122621"},{"key":"e_1_3_5_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbo.2021.100379"},{"key":"e_1_3_5_48_1","volume-title":"Identification of genetic vulnerabilities through whole-genome CRISPR\/Cas9 screening and study of new therapies capable of reversing drug resistance in osteosarcoma [doctoral dissertation]","author":"Murillo D","year":"2025","unstructured":"Murillo D. 2025. Identification of genetic vulnerabilities through whole-genome CRISPR\/Cas9 screening and study of new therapies capable of reversing drug resistance in osteosarcoma [doctoral dissertation]. University of Oviedo: Institutional Repository of the University of Oviedo."},{"key":"e_1_3_5_49_1","doi-asserted-by":"publisher","DOI":"10.1039\/d3nr01801f"},{"key":"e_1_3_5_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano9091208"},{"key":"e_1_3_5_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2013.09.014"},{"key":"e_1_3_5_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13205164"},{"key":"e_1_3_5_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.105090"},{"key":"e_1_3_5_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2013.10.021"},{"key":"e_1_3_5_55_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-17-1152"},{"key":"e_1_3_5_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm050015d"},{"key":"e_1_3_5_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2022.100208"},{"key":"e_1_3_5_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.08.1995"},{"key":"e_1_3_5_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126547"},{"key":"e_1_3_5_60_1","doi-asserted-by":"publisher","DOI":"10.2147\/JEP.S267383"},{"key":"e_1_3_5_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines9040359"},{"key":"e_1_3_5_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b01689"},{"key":"e_1_3_5_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2012.08.022"},{"key":"e_1_3_5_64_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1296091"},{"key":"e_1_3_5_65_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.36588"},{"key":"e_1_3_5_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.06.012"},{"key":"e_1_3_5_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2016.01.001"},{"key":"e_1_3_5_68_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4SC01255K"},{"key":"e_1_3_5_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/natrevmats.2016.14"},{"key":"e_1_3_5_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-016-9889-y"}],"container-title":["Drug Delivery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/10717544.2026.2671485","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T05:16:25Z","timestamp":1778994985000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/10717544.2026.2671485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,11]]},"references-count":69,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12,31]]}},"alternative-id":["10.1080\/10717544.2026.2671485"],"URL":"https:\/\/doi.org\/10.1080\/10717544.2026.2671485","relation":{},"ISSN":["1071-7544","1521-0464"],"issn-type":[{"value":"1071-7544","type":"print"},{"value":"1521-0464","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,11]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=idrd20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=idrd20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2026-01-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-17","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2671485"}}