{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T02:20:47Z","timestamp":1770430847650,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T00:00:00Z","timestamp":1264464000000},"content-version":"vor","delay-in-days":2122,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microcirculation"],"published-print":{"date-parts":[[2004,4,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:bold>Objective:<\/jats:bold> Microvascular abnormalities have been postulated in the pathogenesis of chagasic cardiomyopathy. The objective of this study was to evaluate the relationship between coronary microcirculation and systolic function impairment in baboons with Chagas disease using myocardial contrast echocardiography (MCE).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Seventeen seropositive (5 males, 12 females; mean age 20 years) and 13 age\u2010 and gender\u2010matched seronegative baboons underwent MCE using intravenous octafluoropropane human albumin microspheres. Color\u2010coding was used to enhance tissue contrast in assessing regional myocardium uniformity and texture. Dipyridamole (0.54 mg\/kg) was given to a subset of 4 animals to challenge coronary flow reserve. Systolic indices included left ventricular fractional shortening, velocity of circumferential fiber shortening, and left and right ventricular ejection fractions.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Four of the 17 (24%) seropositive primates had decreased fractional shortening (25 \u00b1 8% vs. 40 \u00b1 5%, <jats:italic>p<\/jats:italic> &lt; .005), velocity of circumferential fiber shortening (1.05 \u00b1 0.36 circ\/s vs. 1.84 \u00b1 0.23 circ\/s, <jats:italic>p<\/jats:italic> &lt; .0001), and reduced right ventricular ejection fraction (44 \u00b1 9% vs. 54 \u00b1 4%, <jats:italic>p<\/jats:italic> &lt; .05) compared to other seropositive animals. Seropositive and seronegative groups showed no significant differences on the coronary microcirculation pattern as evaluated by MCE, including the 4 baboons with systolic function impairment. Moreover, coronary flow vasoreactivity resulted in a significant increase in myocardial flow as detected by color\u2010coding masking.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Chagasic heart disease is present in 24% of seropositive baboons spontaneously infected with <jats:italic>Trypanosoma cruzi<\/jats:italic>. MCE reveals a discrepancy between coronary microcirculation at rest and alterations in myocardial contractility, suggesting preservation of the microvascular integrity in this unique animal model.<\/jats:p>","DOI":"10.1080\/10739680490425976","type":"journal-article","created":{"date-parts":[[2004,4,12]],"date-time":"2004-04-12T15:45:11Z","timestamp":1081784711000},"page":"271-278","source":"Crossref","is-referenced-by-count":10,"title":["Myocardial Contrast Echocardiography in Assessing Microcirculation in Baboons with Chagas Disease"],"prefix":"10.1111","volume":"11","author":[{"given":"MIGUEL","family":"ZABALGOITIA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JAIME","family":"VENTURA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JOSE L.","family":"LOZANO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LORI","family":"ANDERSON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. 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