{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:38:15Z","timestamp":1790980695603,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T00:00:00Z","timestamp":1264464000000},"content-version":"vor","delay-in-days":482,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microcirculation"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p><jats:bold>Objective:<\/jats:bold> Investigate effects of aspirin\/dipyridamole and aspirin on blood viscosity (BV) in subjects with hyperhomocystememia (&gt;14 \u03bcmol\/L) and stable cardiovascular disease (CVD) or \u2265 20% risk for CVD were the aims of this study.<\/jats:p><jats:p><jats:bold>Method:<\/jats:bold> Forty\u2010seven subjects were treated with 14 days of either aspirin\/dipyridamole (25 mg\/200 mg twice\u2010daily) or aspirin (81 mg daily). BV was measured from fasting specimens at 37\u00b0C from whole blood at shear rates ranging from 1,000 to 1s<jats:sup>\u22121<\/jats:sup> by using a scanning capillary viscometer (Rheolog\u2122 Rheologics Inc., Exton, Pennsylvania, USA).<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Aspirin\/dipyridamole was more effective than aspirin therapy in reducing BV at shear rates of 1 s<jats:sup>\u22121<\/jats:sup> (\u22123.03 [\u22123.88, \u22122.17] mPas vs. \u22120.07 [\u22121.06, 0.92] mPas; <jats:italic>P<\/jats:italic>&lt;0.0001) and 2 s<jats:sup>\u22121<\/jats:sup> (\u22121.86 [\u22122.72, \u22121.01] mPas vs. \u22120.21 [\u22121.20, 0.79] mPas; <jats:italic>P<\/jats:italic>=0.0136); however, there were no significant differences in blood viscosity at shear rates of 5 s<jats:sup>\u22121<\/jats:sup> to 1000 s<jats:sup>\u22121<\/jats:sup>. Changes in hematocrit, a major determinant of whole BV, were greater in the aspirin\/dipyridamole group than the aspirin group (<jats:italic>P<\/jats:italic>=0.043). After hematocrit adjustment, differences in BV between aspirin\/dipyridamole and aspirin remained significant at 1s<jats:sup>\u22121<\/jats:sup> (\u22122.78 [\u22123.68, \u22121.88] mPas vs. \u22120.04 [\u22121.05, 0.98] mPas; <jats:italic>P<\/jats:italic>&lt;0.0001) and 2 s<jats:sup>\u22121<\/jats:sup> (\u22121.62 [\u22122.52, \u22120.72] mPas vs. \u22120.17 [\u22121.19, 0.85] mPas; <jats:italic>P<\/jats:italic>=0.0315).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> These findings may have important clinical benefits in the CVD prevention and treatment due to the contribution of BV in tissue perfusion and thrombus formation.<\/jats:p>","DOI":"10.1080\/10739680802229316","type":"journal-article","created":{"date-parts":[[2008,9,12]],"date-time":"2008-09-12T01:05:56Z","timestamp":1221181556000},"page":"615-620","source":"Crossref","is-referenced-by-count":14,"title":["Treatment with Aspirin and Dipyridamole is More Effective than Aspirin in Reducing Low Shear Blood Viscosity"],"prefix":"10.1111","volume":"15","author":[{"given":"ROBERT S.","family":"ROSENSON","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,1,26]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(96)00308-5"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68734-5"},{"key":"e_1_2_7_4_2","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1182\/blood.V64.6.1228.1228","article-title":"Red blood cell deformability influences platelet\u2010vessel wall interaction in flowing blood","volume":"64","author":"Aarts 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