{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:17:58Z","timestamp":1791346678448,"version":"4.3.1"},"reference-count":84,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T00:00:00Z","timestamp":1264464000000},"content-version":"vor","delay-in-days":390,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microcirculation"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Periodic recurrence of painful vaso\u2010occlusive crisis is the defining feature of sickle cell disease. Among multiple pathologies associated with this disease, sickle red cell\u2013endothelium interaction has been implicated as a potential initiating mechanism in vaso\u2010occlusive events. This review focuses on various interrelated mechanisms involved in human sickle red cell adhesion. We discuss <jats:italic>in vitro<\/jats:italic> and microcirculatory findings on sickle red cell adhesion, its potential role in vaso\u2010occlusion, and the current understanding of receptor\u2010ligand interactions involved in this pathological phenomenon. In addition, we discuss the contribution of other cellular interactions (leukocytes recruitment and leukocyte\u2013red cell interaction) to vaso\u2010occlusion, as observed in transgenic sickle mouse models. Emphasis is given to recently discovered adhesion molecules that play a predominant role in mediating human sickle red cell adhesion. Finally, we analyze various therapeutic approaches for inhibiting sickle red cell adhesion by targeting adhesion molecules and also consider therapeutic strategies that target stimuli involved in endothelial activation and initiation of adhesion.<\/jats:p>","DOI":"10.1080\/10739680802279394","type":"journal-article","created":{"date-parts":[[2008,8,20]],"date-time":"2008-08-20T12:02:33Z","timestamp":1219233753000},"page":"97-111","source":"Crossref","is-referenced-by-count":175,"title":["Sickle Red Cell\u2013Endothelium Interactions"],"prefix":"10.1111","volume":"16","author":[{"given":"DHANANJAY K.","family":"KAUL","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"EILEEN","family":"FINNEGAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"GILDA A.","family":"BARABINO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,1,26]]},"reference":[{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V72.4.1216.1216"},{"key":"e_1_2_10_3_2","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1182\/blood.V93.4.1422","article-title":"Anionic polysaccharides inhibit adhesion of sickle erythrocytes to the vascular endothelium and result in improved hemodynamic behavior","volume":"93","author":"Barabino GA","year":"1999","journal-title":"Blood"},{"key":"e_1_2_10_4_2","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1182\/blood.V70.1.152.152","article-title":"Endothelial cell interactions with sickle cell, sickle trait, mechanically injured, and normal erythrocytes under controlled flow","volume":"70","author":"Barabino GA","year":"1987","journal-title":"Blood"},{"key":"e_1_2_10_5_2","first-page":"113","article-title":"Rheological studies of erythrocyte\u2010endothelial cell interactions in sickle cell disease","volume":"240","author":"Barabino GA","year":"1987","journal-title":"Progr Clin Biol Res"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V68.1.301.301"},{"key":"e_1_2_10_7_2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1182\/blood.V41.1.59.59","article-title":"An unusual pattern of neutrophil kinetics in sickle cell anemia","volume":"41","author":"Boggs DR","year":"1973","journal-title":"Blood"},{"key":"e_1_2_10_8_2","doi-asserted-by":"crossref","first-page":"4701","DOI":"10.1182\/blood.V88.12.4701.bloodjournal88124701","article-title":"A multiparameter analysis of sickle erythrocytes in patients undergoing hydroxyurea therapy","volume":"88","author":"Bridges KR","year":"1996","journal-title":"Blood"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V81.8.2137.2137"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10817"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3961486"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1996.0079"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-04-084061"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199611000-00002"},{"key":"e_1_2_10_15_2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3233\/BIR-1994-31109","article-title":"Rheologic and hemodynamic characteristics of red cells of mouse, rat, and human","volume":"31","author":"Chen D","year":"1994","journal-title":"Biorheology"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-05-088732"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200316672"},{"key":"e_1_2_10_18_2","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1182\/blood.V70.5.1245.1245","article-title":"Hemoglobin S gelation and sickle cell disease. [Review]","volume":"70","author":"Eaton WA","year":"1987","journal-title":"Blood"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-02-0713"},{"key":"e_1_2_10_20_2","first-page":"9","article-title":"Heterogeneity of red cells in the sickler: a characteristic with practical clinical and pathophysiological implications","volume":"8","author":"Fabry ME","year":"1982","journal-title":"Blood Cells"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.2.410"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1989.tb24151.x"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01054.2006"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20819"},{"key":"e_1_2_10_25_2","first-page":"167","article-title":"Sickle erythrocytes adhere to endothelial cell monolayers (ECMs) exposed to flowing blood","volume":"240","author":"Grabowski EF","year":"1987","journal-title":"Progr Clin Biol Res"},{"key":"e_1_2_10_26_2","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1182\/blood.V77.2.214.214","article-title":"Beyond hemoglobin polymerization: the red blood cell membrane and sickle disease pathophysiology. [Review]","volume":"77","author":"Hebbel RP","year":"1991","journal-title":"Blood"},{"key":"e_1_2_10_27_2","first-page":"S83","article-title":"Adhesive interactions of sickle erythrocytes with endothelium. [Review]","volume":"100","author":"Hebbel RP","year":"1997","journal-title":"J Clin Invest"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119442"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200006223422512"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198005013021803"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110724"},{"key":"e_1_2_10_32_2","first-page":"145","article-title":"Erythrocyte\/endothelial interactions and the vasocclusive severity of sickle cell disease","volume":"55","author":"Hebbel RP","year":"1981","journal-title":"Progr Clin Biol Res"},{"key":"e_1_2_10_33_2","first-page":"163","article-title":"Erythrocyte\/endothelial interactions in the pathogenesis of sickle\u2010cell disease: a \u201creal logical\u201d assessment","volume":"8","author":"Hebbel RP","year":"1982","journal-title":"Blood Cells"},{"key":"e_1_2_10_34_2","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1182\/blood.V58.5.947.947","article-title":"Modulation of erythrocyte\u2010endothelial interactions and the vasocclusive severity of sickling disorders","volume":"58","author":"Hebbel RP","year":"1981","journal-title":"Blood"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.1080\/10739680490278402"},{"key":"e_1_2_10_36_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109646"},{"key":"e_1_2_10_37_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2001-12-0289"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.73.9.3035"},{"key":"e_1_2_10_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/35051599"},{"key":"e_1_2_10_40_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V54.4.872.872"},{"key":"e_1_2_10_41_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1993.264.2.C251"},{"key":"e_1_2_10_42_2","doi-asserted-by":"publisher","DOI":"10.1080\/10739680490278457"},{"key":"e_1_2_10_43_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118355"},{"key":"e_1_2_10_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1989.tb24179.x"},{"key":"e_1_2_10_45_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.9.3356"},{"key":"e_1_2_10_46_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110960"},{"key":"e_1_2_10_47_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI9225"},{"key":"e_1_2_10_48_2","doi-asserted-by":"publisher","DOI":"10.1080\/10739680600778456"},{"key":"e_1_2_10_49_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200421633"},{"key":"e_1_2_10_50_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01096.2005"},{"key":"e_1_2_10_51_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00639.2005"},{"key":"e_1_2_10_52_2","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1182\/blood.V95.2.368","article-title":"Monoclonal antibodies to alphaVbeta3 (7E3 and LM609) inhibit sickle red blood cell\u2010endothelium interactions induced by platelet\u2010activating factor [see comments]","volume":"95","author":"Kaul DK","year":"2000","journal-title":"Blood"},{"key":"e_1_2_10_53_2","first-page":"497","volume-title":"Sickle Cell Disease and Thalassemias: New Trends in Therapy (INSERM Symposium)","author":"Kaul DK","year":"1995"},{"key":"e_1_2_10_54_2","doi-asserted-by":"publisher","DOI":"10.3109\/10739689609148313"},{"key":"e_1_2_10_55_2","first-page":"179","article-title":"Alterations by leukocytes of erythrocyte flow in microchannels","volume":"12","author":"La Celle PL","year":"1986","journal-title":"Blood Cells"},{"key":"e_1_2_10_56_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2792"},{"key":"e_1_2_10_57_2","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1182\/blood.V92.9.3445","article-title":"Enhanced adherence of sickle erythrocytes to thrombin\u2010treated endothelial cells involves interendothelial cell gap formation","volume":"92","author":"Manodori AB","year":"1998","journal-title":"Blood"},{"key":"e_1_2_10_58_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.6.1955"},{"key":"e_1_2_10_59_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-02-0626"},{"key":"e_1_2_10_60_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112144"},{"key":"e_1_2_10_61_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199804163381617"},{"key":"e_1_2_10_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)31981-6"},{"key":"e_1_2_10_63_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10726"},{"key":"e_1_2_10_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1202-799"},{"key":"e_1_2_10_65_2","doi-asserted-by":"publisher","DOI":"10.1159\/000040859"},{"key":"e_1_2_10_66_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.9.2568"},{"key":"e_1_2_10_67_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.5.1564"},{"key":"e_1_2_10_68_2","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1182\/blood.V68.5.1050.1050","article-title":"Erythrocyte\u2013endothelial cell adherence in sickle cell disorders","volume":"68","author":"Smith BD","year":"1986","journal-title":"Blood"},{"key":"e_1_2_10_69_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199711273372203"},{"key":"e_1_2_10_70_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830310409"},{"key":"e_1_2_10_71_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(200004)63:4<200::AID-AJH7>3.0.CO;2-Q"},{"key":"e_1_2_10_72_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.3.1078"},{"key":"e_1_2_10_73_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI3756"},{"key":"e_1_2_10_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17192-4"},{"key":"e_1_2_10_75_2","first-page":"H881","article-title":"In vivo visualization of oxidative changes in microvessels during neutrophil activation","volume":"264","author":"Suematsu M","year":"1993","journal-title":"Am J Physiol"},{"key":"e_1_2_10_76_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.10.2634.2634"},{"key":"e_1_2_10_77_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.10.3924"},{"key":"e_1_2_10_78_2","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1182\/blood.V82.6.1891.1891","article-title":"Alpha 4 beta 1\u2010integrin expression on sickle reticulocytes: vascular cell adhesion molecule\u20101\u2010dependent binding to endothelium","volume":"82","author":"Swerlick RA","year":"1993","journal-title":"Blood"},{"key":"e_1_2_10_79_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-07-2209"},{"key":"e_1_2_10_80_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.052522799"},{"key":"e_1_2_10_81_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-12-061697"},{"key":"e_1_2_10_82_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113151"},{"key":"e_1_2_10_83_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01056.2003"},{"key":"e_1_2_10_84_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-01-0042"},{"key":"e_1_2_10_85_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-11-056101"}],"container-title":["Microcirculation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1080%2F10739680802279394","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/10739680802279394","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T19:45:35Z","timestamp":1696967135000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1080\/10739680802279394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":84,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["10.1080\/10739680802279394"],"URL":"https:\/\/doi.org\/10.1080\/10739680802279394","archive":["Portico"],"relation":{},"ISSN":["1073-9688","1549-8719"],"issn-type":[{"value":"1073-9688","type":"print"},{"value":"1549-8719","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1]]}}}