{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T13:50:08Z","timestamp":1777557008052,"version":"3.51.4"},"reference-count":61,"publisher":"Informa UK Limited","issue":"3","funder":[{"name":"Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Kochi"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Pharmaceutical Development and Technology"],"published-print":{"date-parts":[[2026,3,16]]},"DOI":"10.1080\/10837450.2026.2623916","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T10:56:19Z","timestamp":1770029779000},"page":"378-394","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Pulmonary targeted inhalational therapy for neutrophillic asthma using a novel simvastatin-rapamycin dry powder inhalation formulation"],"prefix":"10.1080","volume":"31","author":[{"given":"Hafsa","family":"P. V.","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Science Campus","place":["Kochi, India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nithya","family":"Haridas","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Amrita Vishwa Vidyapeetham, AIMS Health Science Campus","place":["Kochi, India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vidya","family":"Viswanad","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Science Campus","place":["Kochi, India"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2026,2,5]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2021.120045"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-022-02706-8"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0178772"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp500808t"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.31487\/j.DDA.2010.01.02"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2015.07.010"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/03639045.2019.1620268"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12060535"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15112601"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13010031"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/1493684"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155946"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13040503"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2020-215986"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/2050-6511-15-67"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-024-06072-y"},{"key":"e_1_3_3_18_1","unstructured":"GINA Strategy Report. 2025. Global Initiative for Asthma \u2013 GINA [Internet]. [cited 2025 May 20]. Available from: https:\/\/ginasthma.org\/2025-gina-strategy-report\/"},{"key":"e_1_3_3_19_1","volume-title":"StatPearls","author":"Hashmi MF","year":"2025","unstructured":"Hashmi MF, Cataletto ME. 2025. Asthma. In: StatPearls [Internet]. [cited 2025 Apr 28]. StatPearls Publishing. Available from: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK430901\/"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105189"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2021.04.014"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2020.105898"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2019.105098"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-012-9765-8"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2017.5635"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-023-03492-2"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/15287394.2020.1827469"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00310.2006"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.22270\/jddt.v9i6.3465"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12100976"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.119684"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102133"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD013268.pub2"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14090846"},{"key":"e_1_3_3_35_1","unstructured":"OECD. 2024. Test No. 403: acute inhalation toxicity [Internet]. [cited 2025 May 10]. Available from: https:\/\/www.oecd.org\/en\/publications\/test-no-403-acute-inhalation-toxicity_9789264070608-en.html"},{"key":"e_1_3_3_36_1","unstructured":"OrphAI Therapeutics [Internet]. 2025. [cited 2025 Nov 19]. Available from: https:\/\/www.orphai-therapeutics.com\/news\/ai-therapeutics-announces-initiation-of-a-phase-ii-clinical-trial-of-lam-001-for-treatment-of-pulmonary-arterial-hypertension-pah-2"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2023.10.029"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-025-01992-y"},{"key":"e_1_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13020211"},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.26452\/ijrps.v11i3.2556"},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics11050207"},{"key":"e_1_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0249683"},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1089\/jamp.2017.1379"},{"key":"e_1_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2019.02.038"},{"key":"e_1_3_3_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11051-022-05502-7"},{"key":"e_1_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.15171\/apb.2019.029"},{"key":"e_1_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics11050233"},{"key":"e_1_3_3_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2016.01.066"},{"key":"e_1_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00528-2021"},{"key":"e_1_3_3_50_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4PM00079J"},{"key":"e_1_3_3_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2018.01.001"},{"key":"e_1_3_3_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2022.122359"},{"key":"e_1_3_3_53_1","first-page":"92","article-title":"Manipulating human dendritic cell phenotype and function with targeted porous silicon nanoparticles","volume":"155","author":"Sterling S","year":"2017","unstructured":"Sterling S et al. 2017. Manipulating human dendritic cell phenotype and function with targeted porous silicon nanoparticles. Biomaterials. 155:92\u2013102.","journal-title":"Biomaterials"},{"key":"e_1_3_3_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano12081299"},{"key":"e_1_3_3_55_1","doi-asserted-by":"publisher","DOI":"10.7324\/JAPS.2019.90106"},{"key":"e_1_3_3_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2023.106679"},{"key":"e_1_3_3_57_1","unstructured":"The United States Pharmacopeial Convention. 2011. Uniformity of dosage units [Internet]. [cited 2025 Dec 26]. Available from: https:\/\/www.usp.org\/sites\/default\/files\/usp\/document\/harmonization\/gen-method\/q0304_stage_6_monograph_25_feb_2011.pdf"},{"key":"e_1_3_3_58_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2015.963054"},{"key":"e_1_3_3_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2024.103051"},{"key":"e_1_3_3_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14050895"},{"key":"e_1_3_3_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-04826-y"},{"key":"e_1_3_3_62_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.212.supp.0725.5414"}],"container-title":["Pharmaceutical Development and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/10837450.2026.2623916","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:16:35Z","timestamp":1777400195000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/10837450.2026.2623916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,5]]},"references-count":61,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3,16]]}},"alternative-id":["10.1080\/10837450.2026.2623916"],"URL":"https:\/\/doi.org\/10.1080\/10837450.2026.2623916","relation":{},"ISSN":["1083-7450","1097-9867"],"issn-type":[{"value":"1083-7450","type":"print"},{"value":"1097-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,5]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iphd20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iphd20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2025-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-12","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}