{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:11:11Z","timestamp":1767658271741,"version":"3.48.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"4_suppl","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Toxicol"],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:p>The Polypropylene Glycol (PPG) Butyl Ethers function as skin-and hair-conditioning agents in cosmetics. Intestinal absorption of the PPG Butyl Ethers was inversely proportional to the molecular weight. In general, the toxicity of the PPG Butyl Ethers decreased as the molecular weight increased. In acute studies, moderate intraperitoneal(IP) doses of various PPG Butyl Ethers caused convulsive seizures in mice and anesthetized dogs, and large oral doses caused decreased activity, anuria, renal tubular swelling and necrosis, and hepatic swelling and necrosis. PPG-2 Butyl Ether vapors were nontoxic by the inhalation route. PPG-2 Butyl Ether was non-toxic in short-term feeding and dermal exposure studies in rats. In animal irritation studies, PPG-2 Butyl Ether caused minor, transient erythema and desquamation; in addition, erythema, edema, ecchymosis, necrosis, and other changes were observed during an acute percutaneous study. PPG-2 Butyl Ether also caused minor to moderate conjunctival irritation and minor corneal injury. PPG-2 Butyl Ether when dermally applied was nontoxic to pregnant rats and was nonteratogenic at doses up to 1.0 ml\/kg\/day. PPG BE800 at concentrations of 0.001% to 0.26% in feed was noncarcinogenic to rats after 2 years of treatment. In clinical studies, PPG BE800 was nonirritating and nonsensitizing to the skin when tested using 200 subjects. PPG-40 Butyl Ether was neither an irritant nor a sensitizer in a repeat-insult patch test using 112 subjects. Although clinical testing did not indicate significant skin irritation is produced by these ingredients, the animal test data did indicate the potential that these ingredients can be irritating. Therefore, it was concluded that the PPG Butyl Ethers can be used safely in cosmetic products if they are formulated to avoid irritation. Data on the component ingredients, Propylene Glycol, PPG, and n-Butyl Alcohol, from previous cosmetic ingredient safety assessments were also considered and found to support the safety of PPG Butyl Ethers.<\/jats:p>","DOI":"10.1080\/10915810152902574","type":"journal-article","created":{"date-parts":[[2002,11,6]],"date-time":"2002-11-06T20:28:31Z","timestamp":1036614511000},"page":"39-52","source":"Crossref","is-referenced-by-count":0,"title":["Amended Final Report on the Safety Assessment of PPG-40 Butyl Ether with an Addendum to Include PPG-2,-4,-5,-9,-12,-14,-15,-16,-17,-18,-20,-22,-24,-26,-30,-33,-52, and-53 Butyl Ethers"],"prefix":"10.1177","volume":"20","member":"179","published-online":{"date-parts":[[2001,1]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/10915819309140646"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/10915819409141005"},{"key":"e_1_2_1_4_1","first-page":"22","volume-title":"Acute toxicity and primary irritancy studies","year":"1989","unstructured":"Bushy Run Research Center.1989a. Acute toxicity and primary irritancy studies. Unpublished data submitted by Cosmetic, Toiletry, and Fragrance Association (CTFA), 4\u201327\u201398. (22 pages.)2"},{"key":"e_1_2_1_5_1","first-page":"67","volume-title":"Ucon lubricant samples. Assessment of toxicity and pulmonary effects in the rat following single endotracheal injection","year":"1989","unstructured":"Bushy Run Research Center.1989b. Ucon lubricant samples. Assessment of toxicity and pulmonary effects in the rat following single endotracheal injection. Unpublished data submitted by CTFA, 5\u20131\u201398. (67 pages.)2"},{"key":"e_1_2_1_6_1","first-page":"261","article-title":"Toxicology of two butoxypolypropylene glycol fly repellents","volume":"4","year":"1951","unstructured":"Carpenter, C. P., F. H. Critchfield, J. H. Nair III, and C. B. Shaffer. 1951. Toxicology of two butoxypolypropylene glycol fly repellents. Arch. Ind. Hyg. Occup. Med.4:261\u2013269.","journal-title":"Arch. Ind. Hyg. Occup. 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Washington, DC: FDA."},{"key":"e_1_2_1_14_1","first-page":"497","volume-title":"Initial submission: Letter from General Electric Company submitting a battery of toxicity studies with silicones in mammals with attachments","year":"1992","unstructured":"General Electric Company.1992. Initial submission: Letter from General Electric Company submitting a battery of toxicity studies with silicones in mammals with attachments. (Study No. GES-159.) NTIS No. OTS0539961 (497 pages)."},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jee\/42.2.281"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jee\/44.1.97"},{"volume-title":"HSDB","year":"1997","key":"e_1_2_1_17_1","unstructured":"Hazardous Substances Data Base (HSDB).1997. Entry on PPG Butyl Ether. HSDB. 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