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Fifty-four male Sprague-Dawley rats were included the study. Equal volume of isotonic saline was injected to control rats. After DOX administration, the animals were divided into four experimental groups: (a) rats given only DOX; (b) rats treated with NAC; (c) rats treated with DFO; (d) rats treated with NAC plus DFO. The combination of N-acetylcysteine and DFO has no beneficial effect on reducing proteinuria in experimentally nephrotic rats, although both of these agents ameliorate the condition when administered separately. It seems likely that detrimental effects of NAC plus DFO could be secondary to its effects on erythrocyte selenium levels demonstrated here. Consequently, the results may propose caution to the use of antioxidant therapeutic strategies such as NAC plus DFO against nephropathy.<\/jats:p>","DOI":"10.1080\/10915810701707403","type":"journal-article","created":{"date-parts":[[2007,12,8]],"date-time":"2007-12-08T01:09:50Z","timestamp":1197076190000},"page":"525-532","source":"Crossref","is-referenced-by-count":5,"title":["Detrimental Effects of\n                    <i>N<\/i>\n                    -Acetylcysteine Plus Desferoxamine Combination in an Experimental Nephrotic Syndrome Model"],"prefix":"10.1177","volume":"26","author":[{"given":"F.","family":"Bulucu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, G\u00fclhane Military Medical Academy, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Oktenli","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine, GATA Haydarpasa Training Hospital, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Kenar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, G\u00fclhane Military Medical Academy, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Koc","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, G\u00fclhane Military Medical Academy, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Ocal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, G\u00fclhane Military Medical Academy, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Karadurmus","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, G\u00fclhane Military Medical Academy, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Inal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, G\u00fclhane Military Medical Academy, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Yamanel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, G\u00fclhane Military Medical Academy, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. 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