{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T22:51:42Z","timestamp":1777071102737,"version":"3.51.4"},"reference-count":134,"publisher":"Informa UK Limited","issue":"5","funder":[{"DOI":"10.13039\/100015614","name":"Corteva Agriscience","doi-asserted-by":"crossref","award":["no grant"],"award-info":[{"award-number":["no grant"]}],"id":[{"id":"10.13039\/100015614","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Journal of Toxicology and Environmental Health, Part B"],"published-print":{"date-parts":[[2020,7,3]]},"DOI":"10.1080\/10937404.2020.1763879","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T06:37:27Z","timestamp":1590475047000},"page":"214-241","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":25,"title":["Relevance of mouse lung tumors to human risk assessment"],"prefix":"10.1080","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5047-0962","authenticated-orcid":false,"given":"Samuel M.","family":"Cohen","sequence":"first","affiliation":[{"name":"Havlik-Wall Professor of Oncology, University of Nebraska Medical Center, Omaha, NE, USA"},{"name":"University of Nebraska Medical Center, Omaha, NE, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhongyu","sequence":"additional","affiliation":[{"name":"Corteva Agriscience, Indianapolis, IN, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1420-4384","authenticated-orcid":false,"given":"James S.","family":"Bus","sequence":"additional","affiliation":[{"name":"Exponent Inc., Alexandria, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2020,5,25]]},"reference":[{"key":"cit0001","unstructured":"ACGIH. 2019. TLVs\u00ae and BEIs\u00ae. ACGIH. www.acgih.org."},{"key":"cit0002","doi-asserted-by":"publisher","DOI":"10.3109\/08958378.2014.905660"},{"key":"cit0003","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2017.09.015"},{"key":"cit0004","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2018.05.011"},{"key":"cit0005","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/53.2.159"},{"key":"cit0006","doi-asserted-by":"publisher","DOI":"10.3109\/10408444.2015.1061477"},{"key":"cit0007","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.062901"},{"key":"cit0008","doi-asserted-by":"publisher","DOI":"10.1080\/10937404.2019.1633718"},{"key":"cit0009","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfz241"},{"key":"cit0010","doi-asserted-by":"publisher","DOI":"10.1080\/10408440500534362"},{"key":"cit0011","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2017.02.017"},{"key":"cit0012","first-page":"469","volume-title":"Histology for pathologists","author":"Bittar H. E. T.","year":"2020"},{"key":"cit0013","doi-asserted-by":"publisher","DOI":"10.1080\/10408444.2018.1439449"},{"key":"cit0014","doi-asserted-by":"publisher","DOI":"10.1177\/0192623309343779"},{"key":"cit0015","doi-asserted-by":"publisher","DOI":"10.1080\/10408440600977677"},{"key":"cit0016","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/57.2.203"},{"issue":"1","key":"cit0017","first-page":"74","volume":"47","author":"Buckpitt A.","year":"1995","journal-title":"Mol. Pharmacol."},{"key":"cit0018","doi-asserted-by":"publisher","DOI":"10.1081\/DMR-120015694"},{"key":"cit0019","doi-asserted-by":"publisher","DOI":"10.1016\/0272-0590(84)90217-3"},{"key":"cit0020","doi-asserted-by":"publisher","DOI":"10.1016\/j.cotox.2017.06.013"},{"key":"cit0021","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2006.10.144"},{"key":"cit0022","doi-asserted-by":"publisher","DOI":"10.1080\/15287390490443696"},{"key":"cit0023","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2012.02.006"},{"key":"cit0024","doi-asserted-by":"publisher","DOI":"10.1080\/10408440500534354"},{"key":"cit0025","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/B978-0-323-39308-9.00026-1","volume-title":"Pulmonary pathology","author":"Chirieac L. R.","year":"2018","edition":"2"},{"key":"cit0026","doi-asserted-by":"publisher","DOI":"10.1016\/0147-6513(79)90033-2"},{"key":"cit0027","doi-asserted-by":"publisher","DOI":"10.1080\/10937400252972162"},{"key":"cit0028","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfh159"},{"key":"cit0029","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2019.01.017"},{"key":"cit0030","doi-asserted-by":"publisher","DOI":"10.1126\/science.2204108"},{"issue":"24","key":"cit0031","first-page":"6493","volume":"51","author":"Cohen S. M.","year":"1991","journal-title":"Cancer Res."},{"key":"cit0032","doi-asserted-by":"publisher","DOI":"10.1080\/10408444.2018.1445700"},{"key":"cit0033","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e318281a30f"},{"key":"cit0034","doi-asserted-by":"publisher","DOI":"10.1080\/10408440500541367"},{"key":"cit0035","doi-asserted-by":"publisher","DOI":"10.3109\/10408444.2013.835784"},{"key":"cit0036","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a112875"},{"key":"cit0037","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfs149"},{"key":"cit0038","doi-asserted-by":"publisher","DOI":"10.1006\/rtph.2002.1545"},{"key":"cit0039","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2011.10.007"},{"key":"cit0040","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2013.02.008"},{"key":"cit0041","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2009.07.002"},{"key":"cit0042","doi-asserted-by":"publisher","DOI":"10.1002\/jat.737"},{"key":"cit0043","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/46.2.266"},{"key":"cit0044","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2018.02.010"},{"key":"cit0045","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfx141"},{"key":"cit0046","doi-asserted-by":"publisher","DOI":"10.1007\/s004200050396"},{"key":"cit0047","doi-asserted-by":"publisher","DOI":"10.1177\/0192623308315360"},{"key":"cit0048","doi-asserted-by":"publisher","DOI":"10.1080\/10408440500534370"},{"key":"cit0049","unstructured":"ECETOC. 1987. The assessment of carcinogenic hazard for human beings exposed to methylene chloride. Technical Report No. 26, European Chemical Industry Ecology and Toxicology Centre, Brussels, Belgium."},{"key":"cit0050","unstructured":"ECETOC (European Chemical Industry Ecology and Toxicology Centre). 1987. The assessment of carcinogenic hazard for human beings exposed to methylene chloride. Technical Report No. 26, January 1987. Brussels, Belgium."},{"key":"cit0051","unstructured":"ECHA. 2017. Guidance on information requirements and chemical safety assessment. Chapter R.7c: Endpoint specific guidance. Version 3.0."},{"key":"cit0052","doi-asserted-by":"publisher","DOI":"10.3109\/10408444.2013.835786"},{"key":"cit0053","unstructured":"EPA. 1997. Registration Eligibility Decision (Red). Paraquat Dichloride. EPA 738-F-96-018, August 1997."},{"key":"cit0054","unstructured":"EPA. 2005. In ed. EPA. Cancer Assessment Review Committee Evaluation of the Carcinogenic Potential of Flonicamid (PC Code 1280126)."},{"key":"cit0055","unstructured":"EPA. 2019. 1,3-Dichloropropene: Report of the cancer assessment review committee. In ed. H.E.D. Office of Chemical Safety and Pollution Prevention. Washington, D.C.: Environmental Protection Agency."},{"key":"cit0056","volume-title":"Guidance for industry statistical aspects of the design, analysis, and interpretation of chronic rodent carcinogenicity studies of pharmaceuticals","author":"FDA","year":"2001"},{"key":"cit0057","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/B978-0-323-39308-9.00031-5","volume-title":"Pulmonary pathology","author":"Flieder D. B.","year":"2018","edition":"2"},{"key":"cit0058","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.105-1469843"},{"key":"cit0059","doi-asserted-by":"publisher","DOI":"10.1016\/0272-0590(92)90136-6"},{"key":"cit0060","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(94)90011-6"},{"key":"cit0061","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-396971-2.00009-9"},{"key":"cit0062","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0638"},{"key":"cit0063","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1977.116.6.1065"},{"key":"cit0064","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2009.04.005"},{"key":"cit0065","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2019.01.038"},{"key":"cit0066","doi-asserted-by":"publisher","DOI":"10.1016\/j.cotox.2017.06.012"},{"key":"cit0067","doi-asserted-by":"publisher","DOI":"10.1080\/10408444.2020.1712589"},{"key":"cit0068","doi-asserted-by":"publisher","DOI":"10.1177\/0960327197016001021"},{"key":"cit0069","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(88)90020-8"},{"key":"cit0070","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61050-2"},{"key":"cit0071","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-0590(83)80148-1"},{"key":"cit0072","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2013.03.009"},{"key":"cit0073","doi-asserted-by":"publisher","DOI":"10.1002\/em.22338"},{"key":"cit0074","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfz185"},{"key":"cit0075","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/8.4.305"},{"key":"cit0076","volume-title":"IARC monographs on the evaluation of carcinogenic risks to humans. Some aromatic amines, hydrazine and related substances, N-Nitrosos compounds and miscellaneous alkylating agents, Vol. 4, pp. 159\u2013712","author":"IARC","year":"1974"},{"key":"cit0077","volume-title":"IARC monographs on the evaluation of carcinogenic risks to humans. Supplement 7. Overall evaluation of carcinogenicity: An updating of IARC monographs","volume":"1","author":"IARC","year":"1987"},{"key":"cit0078","volume-title":"IARC monographs on the evaluation of carcinogenic risks to humans. Supplement 7. Overall evaluation of carcinogenicity: An updating of IARC monographs","volume":"1","author":"IARC","year":"2019"},{"key":"cit0079","volume-title":"Paraquat and diquat","author":"IPCS (International Programme on Chemical Safety)","year":"1984"},{"key":"cit0080","doi-asserted-by":"publisher","DOI":"10.1080\/10408440903164155"},{"key":"cit0081","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2020.104646"},{"key":"cit0082","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/B978-0-323-39308-9.00030-3","volume-title":"Pulmonary pathology","author":"Kerr K. M.","year":"2018","edition":"2"},{"key":"cit0083","first-page":"411","volume":"46","author":"Kim H. P.","year":"2006","journal-title":"Hum Mol Genet."},{"key":"cit0084","doi-asserted-by":"publisher","DOI":"10.1002\/em.22318"},{"key":"cit0085","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfz012"},{"key":"cit0086","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.119.088930"},{"key":"cit0087","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27765"},{"key":"cit0088","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/B978-0-323-39308-9.00027-3","volume-title":"Pulmonary pathology","author":"Lantuejoul S.","year":"2018","edition":"2"},{"key":"cit0089","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1515\/DMDI.2009.24.2-4.229","volume":"20","author":"Lewis D. F. V.","year":"2009","journal-title":"Drug Metab. Drug Interact."},{"key":"cit0090","doi-asserted-by":"publisher","DOI":"10.1289\/EHP844"},{"key":"cit0091","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.111.184671"},{"key":"cit0092","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgg065"},{"key":"cit0093","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kft213"},{"key":"cit0094","doi-asserted-by":"publisher","DOI":"10.1080\/713608373"},{"key":"cit0095","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/B978-0-323-39308-9.00028-5","volume-title":"Pulmonary pathology","author":"Murer B. U.","year":"2018","edition":"2"},{"key":"cit0096","unstructured":"NCI. 1979. Bioassay of styrene for possible carcinogenicity. NCI Technical Report 185, Bethesda, MD."},{"key":"cit0097","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-3376"},{"key":"cit0098","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2007.09.022"},{"key":"cit0099","unstructured":"NRC. 2014. Review of the styrene assessment in the National Toxicology Program 12th Report on Carcinogens."},{"key":"cit0100","unstructured":"NTP. 1986. NTP technical report on toxicology and carcinogenesis studies of CI disperse blue 1 in F344\/N rats and B6C3F1 mice. NIH Publication #86-2555."},{"key":"cit0101","unstructured":"NTP. 2011. Report on carcinogens: Styrene. Twelfth edition. U.S. Department of Health and Human Services Public Health Service National Toxicology Program."},{"key":"cit0102","unstructured":"OECD. 2010. OECD Guidance Document 116 on the design and conduct of chronic toxicity and carcinogenicity studies, supporting TG 451, 452, and 453, Section 4: Statistical and dose response analysis, including benchmark dose and linear extrapolation, NOAELS and NOELS, LOAELS and LOELS."},{"key":"cit0103","first-page":"443","author":"OECD","year":"2011","journal-title":"Extended One-gener Reprod. Toxic. Study"},{"key":"cit0104","unstructured":"OECD. 2012. OECD guidance document 116 on the conduct and design of chronic toxicity and carcinogenicity studies, supporting test guidelines. 451, 452, 453."},{"key":"cit0105","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-019-02602-7"},{"key":"cit0106","doi-asserted-by":"publisher","DOI":"10.1177\/0192623314556516"},{"key":"cit0107","doi-asserted-by":"publisher","DOI":"10.1177\/0192623312447543"},{"key":"cit0108","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.07.001"},{"key":"cit0109","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.39.020188.000431"},{"key":"cit0110","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrgentox.2009.07.003"},{"key":"cit0111","doi-asserted-by":"publisher","DOI":"10.1002\/em.22248"},{"key":"cit0112","doi-asserted-by":"publisher","DOI":"10.1177\/0192623309353423"},{"key":"cit0113","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.11318"},{"key":"cit0114","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kft212"},{"key":"cit0115","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2012.03.004"},{"key":"cit0116","doi-asserted-by":"publisher","DOI":"10.1021\/tx400305w"},{"key":"cit0117","first-page":"1","author":"Shimkin M. B.","year":"1975","journal-title":"Adv. Cancer Res. 21:"},{"key":"cit0118","first-page":"281","volume":"290","author":"Shultz M. A.","year":"1999","journal-title":"J Pharmacol Exp Ther."},{"key":"cit0119","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2004.06.019"},{"key":"cit0120","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2004.06.027"},{"key":"cit0121","volume":"2","author":"Smith C.","year":"2018","journal-title":"Toxicol. Res. Appl."},{"key":"cit0122","doi-asserted-by":"publisher","DOI":"10.1006\/rtph.2001.1493"},{"key":"cit0123","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-0143-1_1"},{"key":"cit0124","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfs127"},{"key":"cit0125","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfw168"},{"key":"cit0126","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfq371"},{"key":"cit0127","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-011-0621-z"},{"issue":"7","key":"cit0128","first-page":"1473","volume":"26","author":"Toth B.","year":"1966","journal-title":"Cancer Res."},{"key":"cit0129","doi-asserted-by":"publisher","DOI":"10.1177\/030089167005600601"},{"key":"cit0130","doi-asserted-by":"publisher","DOI":"10.1002\/em.2850100209"},{"issue":"6","key":"cit0131","first-page":"385","volume":"85","author":"Villeneuve P. J.","year":"1994","journal-title":"Can. J. Public Health"},{"key":"cit0132","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.112.044826"},{"key":"cit0133","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2019.03.012"},{"key":"cit0134","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfx066"}],"container-title":["Journal of Toxicology and Environmental Health, Part B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/10937404.2020.1763879","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T10:33:24Z","timestamp":1722940404000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/10937404.2020.1763879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,25]]},"references-count":134,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,7,3]]}},"alternative-id":["10.1080\/10937404.2020.1763879"],"URL":"https:\/\/doi.org\/10.1080\/10937404.2020.1763879","relation":{},"ISSN":["1093-7404","1521-6950"],"issn-type":[{"value":"1093-7404","type":"print"},{"value":"1521-6950","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,25]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=uteb20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=uteb20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2020-05-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}