{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T02:05:09Z","timestamp":1771812309228,"version":"3.50.1"},"reference-count":144,"publisher":"Informa UK Limited","issue":"7","funder":[{"name":"EUROHEADPAIN-FP7-Health-2013-Innovation","award":["602633"],"award-info":[{"award-number":["602633"]}]},{"name":"Hungarian Brain Research Program","award":["KTIA_NAP_13-A_II\/18"],"award-info":[{"award-number":["KTIA_NAP_13-A_II\/18"]}]},{"name":"Hungarian Brain Research Program","award":["KTIA_NAP_13-A_III\/9"],"award-info":[{"award-number":["KTIA_NAP_13-A_III\/9"]}]},{"DOI":"10.13039\/501100003549","name":"OTKA","doi-asserted-by":"crossref","award":["K 105077"],"award-info":[{"award-number":["K 105077"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Therapeutic Patents"],"published-print":{"date-parts":[[2016,7,2]]},"DOI":"10.1080\/13543776.2016.1189531","type":"journal-article","created":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T18:15:13Z","timestamp":1463076913000},"page":"815-832","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":19,"title":["Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012\u20132015)"],"prefix":"10.1080","volume":"26","author":[{"given":"D\u00e9nes","family":"Z\u00e1dori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e1bor","family":"Veres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levente","family":"Szal\u00e1rdy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e9ter","family":"Kliv\u00e9nyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferenc","family":"F\u00fcl\u00f6p","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f3zsef","family":"Toldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"V\u00e9csei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2016,6,7]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2010.01237.x"},{"key":"CIT0002","first-page":"1","volume":"136","author":"Wolf H.","year":"1974","journal-title":"Scand J Clin Lab Invest Suppl"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.33.6.155"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3793"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(82)91048-4"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(88)90814-X"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1989.tb01881.x"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-008-0052-5"},{"key":"CIT0009","doi-asserted-by":"crossref","first-page":"7463","DOI":"10.1523\/JNEUROSCI.21-19-07463.2001","volume":"21","author":"Hilmas C","year":"2001","journal-title":"J Neurosci"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-3042.2002.00805.x"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05540.x"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2008.06077.x"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2009.06.003"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041108"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M603503200"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2011.07.002"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1007\/BF01101711"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(87)90691-5"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)90826-W"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1016\/0197-0186(95)00091-7"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0116-07.2007"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1988.tb11474.x"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1007\/BF00966592"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2012.06.004"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2009.04.005"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2003.129"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(01)01078-2"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbl033"},{"issue":"3","key":"CIT0029","doi-asserted-by":"crossref","first-page":"S177","DOI":"10.3233\/JAD-132621","volume":"42","author":"Zadori D","year":"2014","journal-title":"J Alzheimers Dis"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1007\/s007020050149"},{"key":"CIT0031","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1038\/npp.2010.39","volume":"35","author":"Potter MC","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.4137\/IJTR.S7052"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1021\/bi7012189"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0508996103"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0610007104"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1021\/bi0620095"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2007.04.010"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-1872"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-116111"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-008-0513-6"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-011-0681-y"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-14-306"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.4137\/IJTR.S16800"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbq112"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.4161\/21624011.2014.957994"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019823"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-2925"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-09-246124"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.AM2013-491"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1186\/2051-1426-2-21"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(95)00006-L"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1021\/jm2006782"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1113873109"},{"key":"CIT0054","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3233\/JAD-140414","volume":"43","author":"Yu D","year":"2015","journal-title":"J Alzheimers Dis"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2011.04.028"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2013.08.007"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802722"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4002148"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-011-0611-4"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-009-0166-4"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)91583-M"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2005.09.034"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2007.04556.x"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00498.x"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20432"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903260107"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3257"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M707925200"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4547(19971101)50:3<457::AID-JNR12>3.0.CO;2-3"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2000.0752051.x"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20359"},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(03)00579-2"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.200500095"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2011.08106.x"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.127"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.05893.x"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.200800109"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.2174\/156802611794863599"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbt157"},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1021\/ml200204m"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1107-14.2014"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1981.tb01737.x"},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2015.11.001"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199701200-00011"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(92)90432-7"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-0135-0_12"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.1042\/bj3260351"},{"key":"CIT0088","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1991.tb03460.x"},{"key":"CIT0089","doi-asserted-by":"publisher","DOI":"10.1021\/bi8010434"},{"key":"CIT0090","doi-asserted-by":"publisher","DOI":"10.1038\/nature12039"},{"key":"CIT0091","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)90227-5"},{"key":"CIT0092","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701834"},{"key":"CIT0093","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(96)00655-0"},{"key":"CIT0094","doi-asserted-by":"publisher","DOI":"10.1016\/0306-3623(92)90017-E"},{"key":"CIT0095","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1992.tb10097.x"},{"key":"CIT0096","doi-asserted-by":"publisher","DOI":"10.1021\/jm00031a015"},{"key":"CIT0097","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-4709-9_26"},{"key":"CIT0098","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-0135-0_15"},{"key":"CIT0099","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199907000-00007"},{"key":"CIT0100","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703250"},{"key":"CIT0101","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(99)00048-9"},{"key":"CIT0102","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(96)00613-9"},{"key":"CIT0103","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-0381-7_35"},{"key":"CIT0104","doi-asserted-by":"publisher","DOI":"10.1016\/0960-894X(95)00255-R"},{"key":"CIT0105","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(98)00517-4"},{"key":"CIT0106","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-0135-0_71"},{"key":"CIT0107","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2005.07.004"},{"key":"CIT0109","doi-asserted-by":"publisher","DOI":"10.1021\/jm970467t"},{"key":"CIT0110","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2007.08.007"},{"key":"CIT0111","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-008-9137-8"},{"key":"CIT0112","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2003.08.038"},{"key":"CIT0113","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.02.052"},{"key":"CIT0114","doi-asserted-by":"publisher","DOI":"10.1038\/ng1542"},{"key":"CIT0115","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.73.8.5249-5251.2005"},{"key":"CIT0116","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp074"},{"key":"CIT0117","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.05.020"},{"key":"CIT0118","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.112.046532"},{"key":"CIT0119","doi-asserted-by":"publisher","DOI":"10.1021\/jm501350y"},{"key":"CIT0120","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1995.65062621.x"},{"key":"CIT0121","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1332.020"},{"key":"CIT0122","doi-asserted-by":"publisher","DOI":"10.1039\/cs9952400401"},{"key":"CIT0123","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1033.2002.02854.x"},{"key":"CIT0124","doi-asserted-by":"publisher","DOI":"10.1021\/bi0616697"},{"key":"CIT0125","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(01)00758-2"},{"key":"CIT0126","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2091-4-13"},{"key":"CIT0127","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(97)10209-8"},{"key":"CIT0128","doi-asserted-by":"publisher","DOI":"10.1039\/b208910f"},{"key":"CIT0129","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1986.tb02826.x"},{"key":"CIT0130","doi-asserted-by":"crossref","first-page":"13792","DOI":"10.1016\/S0021-9258(17)36717-0","volume":"269","author":"Malherbe P","year":"1994","journal-title":"J Biol Chem"},{"key":"CIT0131","doi-asserted-by":"publisher","DOI":"10.1021\/bi047353l"},{"key":"CIT0132","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.10.3491"},{"key":"CIT0133","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1016\/S0021-9258(19)63440-X","volume":"237","author":"Vescia A","year":"1962","journal-title":"J Biol Chem"},{"key":"CIT0134","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1999.7284"},{"key":"CIT0135","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(80)90164-2"},{"key":"CIT0136","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-5952-4_70"},{"key":"CIT0137","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(94)90076-0"},{"key":"CIT0138","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2006.23.866"},{"key":"CIT0139","doi-asserted-by":"publisher","DOI":"10.1016\/S0223-5234(99)00220-2"},{"key":"CIT0140","doi-asserted-by":"publisher","DOI":"10.1007\/BF01345273"},{"key":"CIT0141","doi-asserted-by":"publisher","DOI":"10.1007\/s007260070063"},{"key":"CIT0142","doi-asserted-by":"publisher","DOI":"10.1021\/jm401249c"},{"key":"CIT0155","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.13.1719"},{"key":"CIT0156","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(00)01451-6"},{"key":"CIT0157","doi-asserted-by":"publisher","DOI":"10.2174\/092986709789909602"}],"container-title":["Expert Opinion on Therapeutic Patents"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13543776.2016.1189531","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T04:56:01Z","timestamp":1655873761000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.tandfonline.com\/doi\/full\/10.1080\/13543776.2016.1189531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,7]]},"references-count":144,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2016,6,18]]},"published-print":{"date-parts":[[2016,7,2]]}},"alternative-id":["10.1080\/13543776.2016.1189531"],"URL":"https:\/\/doi.org\/10.1080\/13543776.2016.1189531","relation":{},"ISSN":["1354-3776","1744-7674"],"issn-type":[{"value":"1354-3776","type":"print"},{"value":"1744-7674","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,7]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ietp20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ietp20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"}]}}