{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:42:30Z","timestamp":1791348150901,"version":"4.3.1"},"reference-count":113,"publisher":"Informa UK Limited","issue":"8","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Therapeutic Patents"],"published-print":{"date-parts":[[2016,8,2]]},"DOI":"10.1080\/13543776.2016.1203904","type":"journal-article","created":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T16:45:43Z","timestamp":1467909943000},"page":"947-956","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":49,"title":["Carbonic anhydrase inhibitors: a review on the progress of patent literature (2011\u20132016)"],"prefix":"10.1080","volume":"26","author":[{"given":"Carrie","family":"Lomelino","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"McKenna","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2016,7,11]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(96)00198-2"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.72.1.51"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2010.05.009"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2467"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-0348-8446-4"},{"key":"CIT0006","volume-title":"Carbonic anhydrase: mechanism, regulation, links to disease, and industrial applications","author":"Frost SC","year":"2013"},{"key":"CIT0007","author":"Supuran CT","year":"2015","journal-title":"J Enzyme Inhib Med Chem"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2012.04.044"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1007\/BF00255787"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.05.012"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13552"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2009.07.027"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0908301106"},{"key":"CIT0014","first-page":"47","volume":"139","author":"Schlue WR","year":"1988","journal-title":"Ciba Found Symp"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3554"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1080\/14756360410001689540"},{"key":"CIT0017","doi-asserted-by":"crossref","first-page":"e453543","DOI":"10.1155\/2015\/453543","volume":"2015","author":"Pinard MA","year":"2015","journal-title":"BioMed Res Int"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1002\/med.10025"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1984.tb12314.x"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1021\/bi902007b"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)02022-6"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.24.13589"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.24.10949"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.02.038"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.161301298"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1002\/prot.22144"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M310809200"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.235"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1021\/jm5012935"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00845"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2014.12.030"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1021\/bi00445a054"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1021\/bi002295z"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1021\/bi0480279"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1021\/bi062066y"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1107\/S2052252514004096"},{"issue":"3","key":"CIT0037","first-page":"231","volume":"81","author":"McBain EH","year":"1954","journal-title":"Calif Med"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-014-0467-3"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.2307\/3462001"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2013.160"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2013.08.033"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1039\/C5CC01854D"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.52.8.642"},{"key":"CIT0044","author":"Supuran CT","year":"2016","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.2174\/138161208783877866"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(99)00006-3"},{"issue":"4","key":"CIT0047","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1152\/physrev.1967.47.4.595","volume":"47","author":"Maren TH","year":"1967","journal-title":"Physiol Rev"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2008.07.010"},{"issue":"4","key":"CIT0049","first-page":"703","volume":"22","author":"More RH","year":"1946","journal-title":"Am J Pathol"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp120291"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2012.707646"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2014.0067"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2015.1000857"},{"key":"CIT0054","unstructured":"Karavas E, Koutris E, Samara V, et al. Ophthalmic pharmaceutical composition containing a carbonic anhydrase inhibitor and method for the preparation thereof. US2015080385. 2015."},{"key":"CIT0055","unstructured":"Kim NN, Mcvicar WK, Mccauley TG. Combination compositions of adenosine a1 agonists and carbonic anhydrase inhibitors for reducing intraocular pressure. CN102933220. 2013."},{"key":"CIT0056","unstructured":"Combination of adenosine derivative and carbonic anhydrase inhibitor and beta-receptor blocker. JP2012250949. 2012."},{"key":"CIT0057","unstructured":"Yadav RP, Kadam SN, Bhagit AA, et al. Method for the synthesis of bifunctional cerium oxide nanoparticle with enhanced antioxidant and carbonic anhydrase inhibitory activity. IN1948MU2015. 2015."},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64038-2"},{"issue":"16","key":"CIT0059","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.1200\/JCO.2001.19.16.3660","volume":"19","author":"Chia SK","year":"2001","journal-title":"J Clin Oncol"},{"issue":"5","key":"CIT0060","volume":"33","author":"Chamie K","year":"2015","journal-title":"Urol Oncol Semin Orig Investig"},{"issue":"3","key":"CIT0061","doi-asserted-by":"crossref","first-page":"e0119181","DOI":"10.1371\/journal.pone.0119181","volume":"10","author":"Huang W-J","year":"2015","journal-title":"PLoS ONE"},{"issue":"3","key":"CIT0062","doi-asserted-by":"crossref","first-page":"e33952","DOI":"10.1371\/journal.pone.0033952","volume":"7","author":"Kobayashi M","year":"2012","journal-title":"PLoS ONE"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1186\/1748-717X-5-101"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2012.09.062"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2013.00400"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.188524"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.3390\/molecules20022323"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.422"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2012.10.016"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2009.00994.x"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.08.027"},{"key":"CIT0072","first-page":"926729","volume":"2014","author":"Gonzalez CD","year":"2014","journal-title":"BioMed Res Int"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12004"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-2470"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-4261"},{"key":"CIT0076","doi-asserted-by":"crossref","unstructured":"Brynda J, Cigler P, Gruner B, et al. Carbonic anhydrase inhibitors and method of their production. US2014303390. 2014.","DOI":"10.2210\/pdb4mdm\/pdb"},{"key":"CIT0077","unstructured":"Zimmerman C, Babich JW, Joyal JL, et al. Inhibitors of carbonic anhydrase IX. EP2823826. 2015."},{"key":"CIT0078","doi-asserted-by":"crossref","unstructured":"Ebbesen P, Supuran CT, Scozzafava A, et al. Carbonic anhydrase inhibitors. US2013053392. 2013.","DOI":"10.1007\/978-3-642-38111-9_3"},{"key":"CIT0079","unstructured":"Supuran C, Scozzafava A, Masini E, et al. Carbonic anhydrase inhibitor comprising a dithiocarbamate. WO2013050426. 2013."},{"key":"CIT0080","unstructured":"Lambin P, Winum J-Y. Dual action carbonic anhydrase inhibitors. WO2015025283. 2015."},{"key":"CIT0081","unstructured":"Dubois L, Lambin P, Winum J-Y, et al. Cancer targeting using carbonic anhydrase isoform IX inhibitors. WO2012087115. 2012."},{"key":"CIT0082","unstructured":"Supuran C, Dedhar S, Carta F, et al. Carbonic anhydrase inhibitors with antimetastatic activity. CA2856812. 2012."},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.06.064"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605200"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910380406"},{"key":"CIT0086","unstructured":"Marasco WA, Lo A, Xu C. Carbonic anhydrase IX (G250) antibodies and methods of use thereof. US2013336923. 2013."},{"key":"CIT0087","unstructured":"Marasco WA, Lo A, Xu C. Carbonic anhydrase IX (G250) antibodies and methods of use thereof. WO2007065027. 2007."},{"key":"CIT0088","unstructured":"Zeidler R, Battke C, Kremmer E, et al. Novel antibody to a carbonic anhydrase. AU2011250022. 2013."},{"key":"CIT0089","unstructured":"Renner C, Bauer S, Plesko M, et al. Antibodies directed against carbonic anhydrase IX and methods and uses thereof. WO2011139375. 2011."},{"key":"CIT0090","unstructured":"Pini R, Ratto F, Tatini F, et al. Assembly comprising an absorber of near infrared (nir) light covalently linked to an inhibitor of carbonic anhydrase. US2016015661. 2016."},{"key":"CIT0091","unstructured":"Babich JW, Zimmerman C, Joyal JL, et al. Metal complexes of poly(carboxyl)amine-containing ligands having an affinity for carbonic anhydrase IX. US2016009664. 2016."},{"key":"CIT0092","unstructured":"Kolb H, Chen G, Padgett H, et al. Development of molecular imaging probes for carbonic anhydrase-IX using click chemistry. EP2468734. 2012."},{"key":"CIT0093","unstructured":"Najarian T, Tam PY, Wilson LF, et al. Treatment of pulmonary hypertension with carbonic anhydrase inhibitors. US2016015730. 2016."},{"key":"CIT0094","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-013-9833-4"},{"key":"CIT0095","unstructured":"M\u00fcller WEG, Schr\u00f6der HC, Wang X. Modulator of bone mineralization based on a combination of polyphosphate\/carbonate and carbonic anhydrase activators. WO2015063249. 2015."},{"key":"CIT0096","unstructured":"Murakami H, Yamanishi H, Onji M. Method of inducing immune tolerance comprising administering carbonic anhydrase I. US2014170173. 2014."},{"key":"CIT0097","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1212612"},{"key":"CIT0098","doi-asserted-by":"crossref","first-page":"e967826","DOI":"10.1155\/2014\/967826","volume":"2014","author":"Ozkok A","year":"2014","journal-title":"BioMed Res Int"},{"key":"CIT0099","unstructured":"Corripio GH, Vinas JL, Martinez AS. Use of carbonic anhydrase II for producing a drug. US2013101565. 2013."},{"key":"CIT0100","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.24.14742"},{"key":"CIT0101","unstructured":"Rodriguez VC. Therapeutic and prophylactic uses of cell specific carbonic anhydrase enzymes in treating aging disorders due to oxidative stress and as growrh factors of stem cells. US2011091576. 2011."},{"key":"CIT0102","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2012.08.019"},{"key":"CIT0103","doi-asserted-by":"publisher","DOI":"10.4324\/9780203475300"},{"key":"CIT0104","doi-asserted-by":"publisher","DOI":"10.1002\/9780470508169"},{"key":"CIT0105","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2013.11.016"},{"key":"CIT0106","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2003.09.002"},{"key":"CIT0107","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.06.065"},{"key":"CIT0108","doi-asserted-by":"publisher","DOI":"10.1021\/ci010366a"},{"key":"CIT0109","doi-asserted-by":"publisher","DOI":"10.1016\/S1367-5931(99)80058-1"},{"key":"CIT0110","doi-asserted-by":"publisher","DOI":"10.1038\/481455a"},{"key":"CIT0111","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2016.01.019"},{"key":"CIT0112","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2015.07.024"},{"key":"CIT0113","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.07.060"}],"container-title":["Expert Opinion on Therapeutic Patents"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13543776.2016.1203904","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,16]],"date-time":"2020-08-16T08:26:38Z","timestamp":1597566398000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/13543776.2016.1203904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,11]]},"references-count":113,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8,2]]}},"alternative-id":["10.1080\/13543776.2016.1203904"],"URL":"https:\/\/doi.org\/10.1080\/13543776.2016.1203904","relation":{},"ISSN":["1354-3776","1744-7674"],"issn-type":[{"value":"1354-3776","type":"print"},{"value":"1744-7674","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,11]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ietp20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ietp20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2016-03-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-06-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-07-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}