{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:39:19Z","timestamp":1788910759562,"version":"build-2803163510"},"reference-count":98,"publisher":"Informa UK Limited","issue":"2","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Therapeutic Patents"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1080\/13543776.2017.1252751","type":"journal-article","created":{"date-parts":[[2016,11,18]],"date-time":"2016-11-18T05:38:06Z","timestamp":1479447486000},"page":"191-202","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":24,"title":["Recent advances in therapeutics and drug delivery for the treatment of inner ear diseases: a patent review (2011-2015)"],"prefix":"10.1080","volume":"27","author":[{"given":"Kim","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Southern California, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith S.","family":"Kempfle","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA"},{"name":"Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA, USA"},{"name":"Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA"},{"name":"Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA, USA"},{"name":"Department of Otology and Laryngology, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles E.","family":"McKenna","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Southern California, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2016,11,18]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.889815"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4533"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2015.08.015"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2015.974548"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2008.08.001"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.4155\/tde.12.130"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0030137"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1038\/nature06233"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-013-0394-z"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1080\/000164801300366552"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.3109\/00016488809107371"},{"key":"CIT0047","first-page":"1","volume":"252","author":"Schiller JS","year":"2012","journal-title":"Vital Health Stat"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1002\/ar.22579"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1177\/000348949310200101"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4985-05.2006"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2015.04.014"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2845-09.2009"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(97)70178-5"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.03564"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1242\/dev.046417"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2016.12"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70160-1"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.05.015"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.05.010"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1080\/03655230600895267"},{"key":"CIT0061","first-page":"20","volume":"9","author":"Thompson TL","year":"2009","journal-title":"Ochsner J"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g6544"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.3766\/jaaa.17.1.3"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)01892-0"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4554-03.2004"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.12.5.565"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600951"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.8.4333"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80556-5"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.6426"},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1159\/000374000"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(03)00018-7"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80386-4"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.25.112701.142849"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5421.1837"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.1038\/nm1193"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046355"},{"key":"CIT0080","first-page":"52","volume":"66","author":"Baker K","year":"2009","journal-title":"Adv Otorhinolaryngol"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2011.33"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208783"},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2013.01.005"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20271"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.10.032"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-012-0317-4"},{"key":"CIT0087","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/nrd3625","volume":"11","author":"Kole R","year":"2012","journal-title":"Nat Rev Drug Discov"},{"key":"CIT0088","doi-asserted-by":"publisher","DOI":"10.1101\/gad.235473.113"},{"key":"CIT0089","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-007-0476-5"},{"key":"CIT0092","doi-asserted-by":"publisher","DOI":"10.1517\/14728214.2011.552427"},{"key":"CIT0093","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.068437"},{"key":"CIT0094","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2006.11.012"},{"key":"CIT0095","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2011.08.003"},{"key":"CIT0096","volume-title":"Phase 3 clinical trial: d-methionine to reduce noise-induced hearing","author":"Wilson C","year":"2011"},{"key":"CIT0097","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2011.03.774"},{"key":"CIT0098","doi-asserted-by":"publisher","DOI":"10.2174\/1381612013397807"},{"key":"CIT0099","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1400544111"},{"key":"CIT0100","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2012.05.002"},{"key":"CIT0101","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2013.04.008"},{"key":"CIT0102","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-396456-4.00013-4"},{"key":"CIT0103","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.251194298"},{"key":"CIT0104","doi-asserted-by":"crossref","first-page":"8596","DOI":"10.1523\/JNEUROSCI.23-24-08596.2003","volume":"23","author":"Wang J","year":"2003","journal-title":"J Neurosci"},{"key":"CIT0105","doi-asserted-by":"publisher","DOI":"10.1124\/mol.106.028936"},{"key":"CIT0106","doi-asserted-by":"publisher","DOI":"10.2174\/1568007043337166"},{"key":"CIT0107","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21642"},{"key":"CIT0108","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2006.05.006"},{"key":"CIT0109","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23902"},{"key":"CIT0111","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1152\/physrev.2000.80.4.1483","volume":"80","author":"Rusnak F","year":"2000","journal-title":"Physiol Rev"},{"key":"CIT0112","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1390055"},{"key":"CIT0113","doi-asserted-by":"publisher","DOI":"10.1159\/000241894"},{"key":"CIT0114","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e32830ce796"},{"issue":"494","key":"CIT0115","first-page":"496, 498","volume":"85","author":"Hill SL","year":"2006","journal-title":"Ear Nose Throat J"},{"key":"CIT0116","doi-asserted-by":"publisher","DOI":"10.1080\/00016480601126952"},{"key":"CIT0117","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201003963"},{"key":"CIT0118","doi-asserted-by":"publisher","DOI":"10.1042\/bj2830165"},{"key":"CIT0119","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2015.05.017"},{"key":"CIT0120","doi-asserted-by":"publisher","DOI":"10.1039\/c3nr00338h"},{"key":"CIT0121","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2012.04.007"},{"key":"CIT0122","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-006-9104-4"},{"key":"CIT0123","doi-asserted-by":"publisher","DOI":"10.1159\/000241896"},{"key":"CIT0127","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-bioeng-071813-105206"},{"key":"CIT0128","first-page":"54","volume":"23","author":"Shapiro B","year":"2014","journal-title":"ENT & Audiology News"},{"key":"CIT0129","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-012-2126-0"},{"key":"CIT0130","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25408"},{"key":"CIT0132","doi-asserted-by":"publisher","DOI":"10.1159\/000090685"},{"key":"CIT0133","first-page":"174","volume":"4","author":"Dormer KJ","year":"2008","journal-title":"J Biomed Nanotechnol"},{"key":"CIT0134","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.12.109"},{"key":"CIT0135","doi-asserted-by":"publisher","DOI":"10.1109\/TMAG.2012.2221456"},{"key":"CIT0136","unstructured":"Third rock ventures launches decibel therapeutics with $52 million series a financing to discover new medicines to protect, repair, and restore hearing. Decibel Therapeutics, Inc, 2015.\u00a0[cited 2016 April 25]. Available from: https:\/\/decibeltx.com\/"},{"key":"CIT0137","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2012.12.014"},{"key":"CIT0138","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2014.01.008"},{"key":"CIT0139","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2606-13.2014"},{"key":"CIT0140","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00026"},{"key":"CIT0141","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2014.939167"},{"key":"CIT0142","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.10.016"}],"container-title":["Expert Opinion on Therapeutic Patents"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13543776.2017.1252751","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,15]],"date-time":"2019-09-15T15:02:35Z","timestamp":1568559755000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/13543776.2017.1252751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,18]]},"references-count":98,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,1,5]]},"published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1080\/13543776.2017.1252751"],"URL":"https:\/\/doi.org\/10.1080\/13543776.2017.1252751","relation":{},"ISSN":["1354-3776","1744-7674"],"issn-type":[{"value":"1354-3776","type":"print"},{"value":"1744-7674","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,18]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ietp20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ietp20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"}]}}