{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T11:44:09Z","timestamp":1773834249235,"version":"3.50.1"},"reference-count":108,"publisher":"Informa UK Limited","issue":"3","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Therapeutic Patents"],"published-print":{"date-parts":[[2017,3,4]]},"DOI":"10.1080\/13543776.2017.1261111","type":"journal-article","created":{"date-parts":[[2016,11,12]],"date-time":"2016-11-12T22:43:26Z","timestamp":1478990606000},"page":"311-345","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":88,"title":["An updated patent review: xanthine oxidase inhibitors for the treatment of hyperuricemia and gout (2011-2015)"],"prefix":"10.1080","volume":"27","author":[{"given":"Ritu","family":"Ojha","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jagjeet","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Rayat-Bahara group of Institutes, Hoshiarpur, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anu","family":"Ojha","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, DIT University, Dehradun, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harbinder","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahil","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunal","family":"Nepali","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2016,11,28]]},"reference":[{"key":"CIT0001","first-page":"2158","volume-title":"Harrison\u2019s principles of internal medicine","author":"Wortmann RL.","year":"1998","edition":"14"},{"key":"CIT0002","first-page":"2513","volume-title":"The metabolic and molecular bases of inherited disease","author":"Becker MA","year":"2001","edition":"8"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780341203"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199345020-00004"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1124\/pr.58.1.6"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-199305040-00017"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.3810\/pgm.1999.10.1.706"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1007\/s100670050005"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200005000-00010"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1021\/ja027388d"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.2174\/0929867023371229"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.200600087"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.21.2857"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp030733"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.2174\/0929867023371229"},{"key":"CIT0016","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1016\/S0021-9258(18)63065-0","volume":"245","author":"Massey V","year":"1970","journal-title":"J Bio Chem"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196611)19:11<1489::AID-CNCR2820191105>3.0.CO;2-F"},{"key":"CIT0018","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1016\/S0021-9258(18)63065-0","volume":"245","author":"Massey V","year":"1970","journal-title":"J Biol Chem"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1007\/s00775-014-1210-x"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M402077200"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2011.04.004"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-827X(01)01160-0"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.5570220303"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4838(99)00023-0"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1039\/a907673e"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.33.3113"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1039\/c39950002041"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1007\/s10822-009-9314-z"},{"key":"CIT0029","first-page":"437","volume":"2","author":"Sinclair DS","year":"1975","journal-title":"J Rheumatol"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200831080-00002"},{"key":"CIT0031","doi-asserted-by":"crossref","unstructured":"Seiji S, Kunihiko T, Takeshi N. A novel xanthine dehydrogenase inhibitor (BOF-4272). In: Harkness RA, Elion GB, Z\u00f6llner N, editors. Purine and Pyrimidine Metabolism in Man VII, Volume 309A of the series Advances in Experimental Medicine and Biology. New York (US): Springer. 1991; p. 135\u2013138.","DOI":"10.1007\/978-1-4899-2638-8_30"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M208307200"},{"issue":"9","key":"CIT0033","first-page":"S531","volume":"48","author":"Zhao L","year":"2003","journal-title":"Arthritis Rheum"},{"key":"CIT0034","first-page":"307","volume":"104","author":"Horiuchi H","year":"1999","journal-title":"Res Commun Mol Pathol Pharmacol"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(93)90201-R"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(93)90033-E"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1081\/NCN-200027372"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2007.03016.x"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1177\/0091270008322035"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1592\/phco.30.6.594"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050373"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1002\/art.24209"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-014-0935-8"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1021\/np970237h"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1016\/j.theochem.2004.04.003"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)00442-4"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2009.09.076"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2011.04.140"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.01.058"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2013.09.087"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2014.07.041"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.05.016"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2015.10.022"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1016\/j.fshw.2015.11.001"},{"key":"CIT0056","first-page":"240","volume":"3","author":"Umamaheswari M","year":"2011","journal-title":"Der Pharma Chemica"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2011.652960"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032214"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5b03386"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1039\/c1ib00076d"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1021\/jf2029829"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1039\/c2ib00185c"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1021\/np500320g"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.12.031"},{"key":"CIT0065","first-page":"127","volume":"7","author":"Kaur C","year":"2015","journal-title":"J Chem Pharm Res"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.01.016"},{"key":"CIT0067","first-page":"1","volume":"30","author":"Virdi HS","year":"2014","journal-title":"J Enzyme Inhib Med Chem"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-015-1382-0"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2014.01.016"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2011.01.058"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2014.08.007"},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2012.02.009"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(84)90743-5"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1021\/cr020059j"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2012.07.001"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.01.055"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2012.10.029"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2012.11.057"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2014.01.050"},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2010.11.034"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.12686"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.12.055"},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.08.056"},{"key":"CIT0084","first-page":"145","volume":"7","author":"Chopra B","year":"2015","journal-title":"Der Pharma Chemica"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201200296"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.08.014"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.1016\/j.jorganchem.2015.03.033"},{"key":"CIT0088","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2011.07.039"},{"key":"CIT0089","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201000429"},{"key":"CIT0090","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2015.01.021"},{"key":"CIT0091","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2016.05.055"},{"key":"CIT0092","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytol.2015.03.005"},{"key":"CIT0093","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2015.12.024"},{"key":"CIT0094","first-page":"445","volume":"37","author":"Sevilay C","year":"2012","journal-title":"J Biochem"},{"key":"CIT0095","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2013.08.011"},{"key":"CIT0096","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201400342"},{"key":"CIT0119","first-page":"299","volume":"45","author":"Philip CR","year":"2016","journal-title":"AFP"},{"key":"CIT0120","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21772"},{"key":"CIT0121","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-eular.3734"},{"key":"CIT0122","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21773"},{"key":"CIT0123","doi-asserted-by":"publisher","DOI":"10.1097\/RHU.0000000000000235"},{"key":"CIT0124","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2012.05.025"},{"key":"CIT0125","doi-asserted-by":"publisher","DOI":"10.1002\/art.34488"},{"key":"CIT0127","doi-asserted-by":"publisher","DOI":"10.1002\/art.24209"},{"key":"CIT0129","doi-asserted-by":"publisher","DOI":"10.1159\/000434633"},{"key":"CIT0130","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(63)90012-1"},{"key":"CIT0131","doi-asserted-by":"publisher","DOI":"10.1080\/14756360500112326"},{"key":"CIT0132","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.08.087"},{"key":"CIT0133","doi-asserted-by":"publisher","DOI":"10.2174\/092986707781058805"}],"container-title":["Expert Opinion on Therapeutic Patents"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13543776.2017.1261111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T06:09:40Z","timestamp":1657692580000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/13543776.2017.1261111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,28]]},"references-count":108,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,1,31]]},"published-print":{"date-parts":[[2017,3,4]]}},"alternative-id":["10.1080\/13543776.2017.1261111"],"URL":"https:\/\/doi.org\/10.1080\/13543776.2017.1261111","relation":{},"ISSN":["1354-3776","1744-7674"],"issn-type":[{"value":"1354-3776","type":"print"},{"value":"1744-7674","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,28]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ietp20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ietp20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"}]}}