{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T23:23:34Z","timestamp":1778714614463,"version":"3.51.4"},"reference-count":56,"publisher":"Informa UK Limited","issue":"11","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573347"],"award-info":[{"award-number":["81573347"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Key Project of NSFC for International Cooperation","doi-asserted-by":"publisher","award":["81420108027"],"award-info":[{"award-number":["81420108027"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009108","name":"Young Scholars Program of Shandong University","doi-asserted-by":"publisher","award":["2016WLJH32"],"award-info":[{"award-number":["2016WLJH32"]}],"id":[{"id":"10.13039\/100009108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003091","name":"Major Project of Science and Technology of Shandong Province","doi-asserted-by":"publisher","award":["2015ZDJS04001"],"award-info":[{"award-number":["2015ZDJS04001"]}],"id":[{"id":"10.13039\/501100003091","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Therapeutic Patents"],"published-print":{"date-parts":[[2017,11,2]]},"DOI":"10.1080\/13543776.2017.1360283","type":"journal-article","created":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T06:19:49Z","timestamp":1501136389000},"page":"1277-1286","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":8,"title":["Identification of spirocyclic or phosphate substituted quinolizine derivatives as novel HIV-1 integrase inhibitors: a patent evaluation of WO2016094197A1, WO2016094198A1 and WO2016154527A1"],"prefix":"10.1080","volume":"27","author":[{"given":"Xiqiang","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2017,8,2]]},"reference":[{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1002\/med.20241"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00497"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2013.01.007"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1039\/C4MB00147H"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a007161"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.2174\/156802609789630910"},{"issue":"2","key":"CIT0008","first-page":"190","volume":"10","author":"Klibanov OM","year":"2009","journal-title":"Curr Opin Investig Drugs"},{"issue":"46","key":"CIT0009","first-page":"1","volume":"46","author":"Rowley M","year":"2008","journal-title":"Prog Med Chem"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3282f12377"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2009.11.004"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328331c81e"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1177\/1060028013513558"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2010.05.001"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01209-10"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00157-11"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1478"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2012.661713"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2009.09.114"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.05.010"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1039\/C5CC06170A"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2468"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.2174\/156802611797183230"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-198631030-00002"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200161020-00011"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200363150-00006"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201402393"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2014.12.001"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1021\/jm500984b"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.2174\/1386207043328544"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.2174\/138955707782331722"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2010.02.018"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.2174\/138955711797655407"},{"issue":"8","key":"CIT0044","first-page":"1528","volume":"19","author":"Song Y","year":"2013","journal-title":"Curr Pharm Des"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.2174\/13816128113199990505"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.2174\/1386207317666140122101631"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00543"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddtec.2004.10.009"},{"issue":"9","key":"CIT0049","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1016\/j.bmcl.2017.02.039","volume":"27","author":"Pryde DC","year":"2017","journal-title":"Bioorg Med Chem Lett"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1021\/jm200208d"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00738"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b00332"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg881"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1021\/jm501799k"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki268"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1124\/mol.105.020321"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2009.03.025"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001101"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2012.09.018"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1021\/jm000176b"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1021\/jm900597q"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1021\/jm0494669"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1021\/jm8007085"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2010.11.033"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1021\/jm1014692"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2011.10.058"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1039\/C5MD00439J"}],"container-title":["Expert Opinion on Therapeutic Patents"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13543776.2017.1360283","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T06:36:40Z","timestamp":1507012600000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/13543776.2017.1360283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,2]]},"references-count":56,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2017,7,12]]},"published-print":{"date-parts":[[2017,11,2]]}},"alternative-id":["10.1080\/13543776.2017.1360283"],"URL":"https:\/\/doi.org\/10.1080\/13543776.2017.1360283","relation":{},"ISSN":["1354-3776","1744-7674"],"issn-type":[{"value":"1354-3776","type":"print"},{"value":"1744-7674","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,2]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ietp20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ietp20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"}]}}