{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T17:59:36Z","timestamp":1790531976124,"version":"4.1.0"},"reference-count":136,"publisher":"Informa UK Limited","issue":"1","funder":[{"DOI":"10.13039\/501100004084","name":"Korea Science and Engineering Foundation","doi-asserted-by":"publisher","award":["2014R1A2A10052872"],"award-info":[{"award-number":["2014R1A2A10052872"]}],"id":[{"id":"10.13039\/501100004084","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Therapeutic Patents"],"published-print":{"date-parts":[[2018,1,2]]},"DOI":"10.1080\/13543776.2017.1378426","type":"journal-article","created":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T05:48:27Z","timestamp":1549518507000},"page":"47-59","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":50,"title":["Caspase inhibitors: a review of recently patented compounds (2013-2015)"],"prefix":"10.1080","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3910-5611","authenticated-orcid":false,"given":"Hyemin","family":"Lee","sequence":"first","affiliation":[{"name":"Cancer Molecular Targeted Herbal Research Center, College of Korean Medicine, Kyung Hee University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Ah","family":"Shin","sequence":"additional","affiliation":[{"name":"Cancer Molecular Targeted Herbal Research Center, College of Korean Medicine, Kyung Hee University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Hee","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of East West Medical Science, Graduate School of East West Medical Science Kyung Hee University, Yongin, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deoksoo","family":"Ahn","sequence":"additional","affiliation":[{"name":"Cancer Molecular Targeted Herbal Research Center, College of Korean Medicine, Kyung Hee University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Geun","family":"Kim","sequence":"additional","affiliation":[{"name":"Cancer Molecular Targeted Herbal Research Center, College of Korean Medicine, Kyung Hee University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju-Ha","family":"Kim","sequence":"additional","affiliation":[{"name":"Cancer Molecular Targeted Herbal Research Center, College of Korean Medicine, Kyung Hee University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2423-1973","authenticated-orcid":false,"given":"Sung-Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Cancer Molecular Targeted Herbal Research Center, College of Korean Medicine, Kyung Hee University, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2017,9,18]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2005.01570.x"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100934"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-016-5035-9"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023635510363"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpb.2008.05.010"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1038\/35037710"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099320"},{"key":"CIT0008","first-page":"267","volume":"54","author":"Zlender V","year":"2003","journal-title":"Arh Hig Rada Toksikol"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.15.1.269"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1038\/34112"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1006\/excr.2000.4840"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2011.163"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a008730"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.8.F21"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13120"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.7046.1"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2015.02.002"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.03.034"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12374"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1258\/000456305774538238"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.01057.x"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1186-0"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2012.09.008"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1159\/000335659"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2184.2012.00814.x"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4402044"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4400594"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.280.4.H1608"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1078\/0065-1281-00601"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002275"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-005-0017-1"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23167"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1074"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2006.01595.x"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318257745d"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21664"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.5414\/CPP41441"},{"key":"CIT0038","first-page":"1198","volume":"5","author":"Poordad FF","year":"2004","journal-title":"Curr Opin Investig Drugs"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2004.08.027"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2008.02.017"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1999.1057"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2004.09.017"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2013.06.003"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(02)02484-6"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-12-05069.2003"},{"key":"CIT0046","first-page":"S2","volume":"2","author":"Kuladip JBB","year":"2013","journal-title":"Transl Med"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000193"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2004.07.021"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705662"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.31.1.176"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.03.032"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1159\/000357939"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04269.x"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2007.06.014"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.3171\/spi.2005.2.3.0327"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1016\/S1130-1473(09)70130-7"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100459"},{"key":"CIT0058","first-page":"473","volume":"66","author":"Kudelova J","year":"2015","journal-title":"J Physiol Pharmacol"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24747"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4402034"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1051\/vetres:2004059"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aad3099"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.15.52"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2016.01.006"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1126\/stke.3582006pe44"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1023\/A:1024116916932"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301377"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1517\/17425240902758188"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.2174\/156802609787521571"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2013.01.001"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/469679"},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2011.07.003"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20120037"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2015.1018245"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2012.86"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2015.11.012"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1111\/jfd.12315"},{"key":"CIT0078","unstructured":"Bonefeld CM, Geisler C Treatment of contact dermatitis\nPCT\/DK2015\/050068. 2015."},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2011.157"},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.115105"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2015.01.011"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-04-01386.2000"},{"key":"CIT0083","unstructured":"Peptide TC Inhibitors of Caspase 2 Activation.\nUS20150148302 A1. 2015."},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(01)01618-4"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053473"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2927"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-014-9687-3"},{"key":"CIT0088","doi-asserted-by":"publisher","DOI":"10.2174\/138955710791384081"},{"key":"CIT0089","volume":"2016","author":"Zheng X","journal-title":"J Phys Chem B"},{"key":"CIT0090","unstructured":"Offen D, Aharony I Peptides for the treatment of neurodegenerative diseases.\nEP2906583 A1. 2014."},{"key":"CIT0091","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.02.003"},{"key":"CIT0092","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.10.037"},{"key":"CIT0093","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6379-11.2012"},{"key":"CIT0094","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2071-10.2010"},{"key":"CIT0095","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M001475200"},{"key":"CIT0096","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5874-09.2010"},{"key":"CIT0097","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2012.08.004"},{"key":"CIT0098","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12250"},{"key":"CIT0099","unstructured":"Anagli J, Seyfried D Methods, systems, and compositions for calpain inhibition.\nUS9074019 B2. 2015."},{"key":"CIT0100","unstructured":"Nelson A Use of cyclodextrins for the treatment of cerebral ischaemia and central nervous system injury\nWO2000004888A2. 2000."},{"key":"CIT0101","unstructured":"Ellerby LM, Ellman JA, Leyva MJ Caspase inhibitors and uses thereof.\nUS20140011847 A1. 2014."},{"key":"CIT0102","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2005.01.006"},{"key":"CIT0103","unstructured":"Xu F, Sun C, Wang J Uses of 2-[(4-formyl-pyrazol-5-yl)-thio]acetic acid derivatives in preparation of Caspase-3 inhibitors.\nCN104138372 A. 2013."},{"key":"CIT0104","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2002.00970.x"},{"key":"CIT0105","volume":"201310371351","author":"Fan W","journal-title":"C"},{"key":"CIT0106","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1503"},{"key":"CIT0107","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2007.05.006"},{"key":"CIT0108","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2015.2462"},{"issue":"181","key":"CIT0109","first-page":"6810","volume":"2008","author":"Watanabe C","year":"1950","journal-title":"J Immunol"},{"key":"CIT0110","unstructured":"Estaquier J Caspase-6 inhibitors for treating t cell activation and\/or proliferation disorders.\nWO2014060392 A1. 2014."},{"key":"CIT0111","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4652(199902)178:2<133::AID-JCP2>3.0.CO;2-5"},{"key":"CIT0112","doi-asserted-by":"publisher","DOI":"10.1007\/0-387-23752-6_26"},{"key":"CIT0113","unstructured":"Ahlfors J, Mekouar K Selective caspase inhibitors and uses thereof.\nUS9045524 B2. 2015."},{"key":"CIT0114","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2015.272"},{"key":"CIT0115","first-page":"689","volume":"40","author":"Tang J","year":"2004","journal-title":"Zhonghua Yan Ke Za Zhi"},{"key":"CIT0116","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2014.08.002"},{"key":"CIT0117","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-011-0837-4"},{"key":"CIT0118","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067583"},{"key":"CIT0119","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-11-0989"},{"key":"CIT0120","unstructured":"Miao ZH, Li JX, Feng JM Application of dabrafenib for programmed necrosis inhibition and liver protection.\nCN103520162 B. 2013."},{"key":"CIT0121","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60398-5"},{"key":"CIT0122","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-2515"},{"key":"CIT0123","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60898-4"},{"key":"CIT0124","unstructured":"Zack DJ, Welsbie DS, Yang Z Compounds and methods of use thereof for treating neurodegenerative disorders.\nWO2013177367 A2. 2013."},{"key":"CIT0125","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(02)02329-4"},{"key":"CIT0126","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1402819111"},{"key":"CIT0127","unstructured":"Bannen L c-Met modulators and methods of use\nUS20070054928 A1. 2007."},{"key":"CIT0128","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-015-0238-2"},{"key":"CIT0129","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-1385"},{"key":"CIT0130","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2015.12.009"},{"key":"CIT0131","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.4197"},{"key":"CIT0132","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.35.6345"},{"key":"CIT0133","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-3387"},{"key":"CIT0134","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054014"},{"key":"CIT0135","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-4889"},{"issue":"1","key":"CIT0136","first-page":"Cd009782","volume":"15","author":"Cheng JW","year":"2016","journal-title":"Cochrane Database Syst Rev"}],"container-title":["Expert Opinion on Therapeutic Patents"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13543776.2017.1378426","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,30]],"date-time":"2020-08-30T06:21:18Z","timestamp":1598768478000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/13543776.2017.1378426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,18]]},"references-count":136,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1,2]]}},"alternative-id":["10.1080\/13543776.2017.1378426"],"URL":"https:\/\/doi.org\/10.1080\/13543776.2017.1378426","relation":{},"ISSN":["1354-3776","1744-7674"],"issn-type":[{"value":"1354-3776","type":"print"},{"value":"1744-7674","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,18]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ietp20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ietp20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2016-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-09-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-09-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}