{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:57:21Z","timestamp":1790783841352,"version":"4.1.0"},"reference-count":120,"publisher":"Informa UK Limited","issue":"1","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Therapeutic Patents"],"published-print":{"date-parts":[[2023,1,2]]},"DOI":"10.1080\/13543776.2023.2178300","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T04:32:45Z","timestamp":1675830765000},"page":"51-66","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":7,"title":["New designs for HIV-1 integrase inhibitors: a patent review (2018-present)"],"prefix":"10.1080","volume":"33","author":[{"given":"Yoshiyuki","family":"Taoda","sequence":"first","affiliation":[{"name":"Laboratory for Medicinal Chemistry Research, Shionogi Pharmaceutical Research Center, Shionogi & Co., Ltd, Toyonaka-shi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Laboratory for Medicinal Chemistry Research, Shionogi Pharmaceutical Research Center, Shionogi & Co., Ltd, Toyonaka-shi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Seki","sequence":"additional","affiliation":[{"name":"Laboratory for Medicinal Chemistry Research, Shionogi Pharmaceutical Research Center, Shionogi & Co., Ltd, Toyonaka-shi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,2,14]]},"reference":[{"key":"cit0001","unstructured":"UNAIDS Global HIV & AIDS Statistics\u2014Fact sheet [cited Oct 2022 21]. Available from: https:\/\/www.unaids.org\/en\/resources\/fact-sheet"},{"key":"cit0002","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199803263381301"},{"key":"cit0003","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32835cb997"},{"key":"cit0004","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105243"},{"key":"cit0005","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3283324283"},{"key":"cit0006","doi-asserted-by":"publisher","DOI":"10.3947\/ic.2020.0100"},{"key":"cit0007","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2018.1457648"},{"key":"cit0008","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2022.2081153"},{"key":"cit0009","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2020.1717470"},{"key":"cit0010","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2010.12.005"},{"key":"cit0011","doi-asserted-by":"publisher","DOI":"10.1021\/jm400674a"},{"key":"cit0012","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113787"},{"key":"cit0013","doi-asserted-by":"publisher","DOI":"10.1021\/jm800245z"},{"key":"cit0014","doi-asserted-by":"publisher","DOI":"10.1021\/jm0600139"},{"issue":"46","key":"cit0015","first-page":"1","volume":"46","author":"Rowley M","year":"2008","journal-title":"Prog Med Chem"},{"issue":"2","key":"cit0016","first-page":"190","volume":"10","author":"Klibanov OM","year":"2009","journal-title":"Curr Opin Invest Drugs"},{"key":"cit0017","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3181e9a87a"},{"key":"cit0018","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02568-12"},{"key":"cit0019","doi-asserted-by":"publisher","DOI":"10.1021\/jm400645w"},{"key":"cit0020","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01209-10"},{"key":"cit0021","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04844-14"},{"key":"cit0022","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03909-14"},{"key":"cit0023","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01474-16"},{"key":"cit0024","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32666-0"},{"key":"cit0025","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkaa355"},{"key":"cit0026","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkab276"},{"key":"cit0027","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2013.04.010"},{"key":"cit0028","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2014.898753"},{"key":"cit0029","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2012.09.033"},{"key":"cit0030","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.347534"},{"key":"cit0031","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-10-144"},{"key":"cit0032","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004171"},{"key":"cit0033","doi-asserted-by":"publisher","DOI":"10.1021\/ml500002n"},{"key":"cit0034","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02719-13"},{"key":"cit0035","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2016.08.037"},{"key":"cit0036","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.816793"},{"key":"cit0037","volume-title":"Conference on Retroviruses and Opportunistic Infections (CROI)","author":"Mitchell M","year":"2017"},{"key":"cit0038","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009671"},{"key":"cit0039","volume-title":"The 24th International AIDS Conference","author":"Meng X","year":"2022"},{"key":"cit0040","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.24.13659"},{"key":"cit0041","doi-asserted-by":"publisher","DOI":"10.1021\/bi961849o"},{"key":"cit0042","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay8015"},{"key":"cit0043","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.150220297"},{"key":"cit0044","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-5-114"},{"key":"cit0045","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.66.11.6361-6369.1992"},{"key":"cit0046","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.12.5.2331"},{"key":"cit0047","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.18.11.1225"},{"issue":"24","key":"cit0048","first-page":"8420","volume":"14","author":"Kawasuji T","year":"2006","journal-title":"Part 2: A two-metal Binding Model as A Potential Mechanism of HIV Integrase Inhibitors Bioorg Med Chem"},{"key":"cit0049","doi-asserted-by":"publisher","DOI":"10.1021\/jm3010459"},{"key":"cit0050","doi-asserted-by":"publisher","DOI":"10.1021\/jm301550c"},{"key":"cit0051","unstructured":"Graham TH, Yu T, Zhang Y, et al. Tetracyclic heterocycle compounds useful as HIV integrase inhibitors. WO2018102485A1. 2018"},{"key":"cit0052","unstructured":"Hartingh TJ, Mccauley JA, Yu T, et al. Tetracyclic heterocycle compounds useful as HIV integrase inhibitors. WO2022177840A1. 2022"},{"key":"cit0053","unstructured":"Graham TH, Waddell ST, Cauley JA, et al. Tricyclic heterocycle compounds useful as HIV integrase inhibitors. WO2018102634A1. 2018"},{"key":"cit0054","unstructured":"Embrey MW, Hartingh TJ, LabroLi M, et al. Tricyclic heterocycle compounds useful as HIV integrase inhibitors. WO2019160783A1. 2019"},{"key":"cit0055","unstructured":"Yu T, Apgar JM, Whitehead A, et al. Tricyclic heterocycle compounds useful as HIV integrase inhibitors. WO2019209667A1. 2019"},{"key":"cit0056","unstructured":"Yu T, Whitehead A, Chen Y, et al. Tricyclic heterocycle compounds useful as HIV integrase inhibitors. WO2019236396A1. 2019"},{"key":"cit0057","unstructured":"Chu H, Gonzalez BAZ, Guo H, et al. Bridged tricyclic carbamoylpyridone compounds and their pharmaceutical use. WO2020197991A1. 2020"},{"key":"cit0058","unstructured":"Jiang L, Lin DW, Mitchell ML, et al. Tetracyclic compounds for treating infection. WO2021173522A1. 2021"},{"key":"cit0059","unstructured":"Chu H, Guo H, Jiang L, et al. Bridged tricyclic carbamoylpyridone compounds and uses thereof. WO2022072520A1. 2022"},{"key":"cit0060","unstructured":"Chu H, Gonzalez BAZ, Guo H, et al. Substituted pyridotriazine compounds and uses thereof. WO2022159387A1. 2022"},{"key":"cit0061","unstructured":"Taoda Y. Polycyclic pyridone derivative. WO2019230857A1. 2019"},{"key":"cit0062","unstructured":"Taoda Y, Unoh Y Polycyclic carbamoylpyridone derivative. WO2019230858A1. 2019"},{"key":"cit0063","unstructured":"Tomida Y, Kawasuji T Polycyclic pyridopyrazine derivative. WO2021107065A1. 2021"},{"key":"cit0064","unstructured":"Mo Y, Lin C, Zhao A. Sulfur-containing polycyclic-hydroxypyridone carboxamide analog against HIV and application thereof. WO2019223408A1. 2019"},{"key":"cit0065","unstructured":"Ivachtchenko AV, Sachuk NF, Ivashchenko AA, et al. Annelated 9-hydroxy-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[l,2-\u03b1]pyrazine-7-carboxamides as HIV integrase inhibitors. WO2020246910A1. 2020"},{"key":"cit0066","unstructured":"Zhou Y, Liu J. Preparation of polycyclic pyridone derivatives and used for the prevention and\/or treatment of viral infectious diseases. CN112521386A1. 2021"},{"key":"cit0067","unstructured":"Cao Y, Xie Y, Nie W, et al. Preparation of alkynyl-coupled difluoroanilinopyridone as HIV integrase inhibitor. CN114149449. 2022"},{"key":"cit0068","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq410"},{"key":"cit0069","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00821-17"},{"key":"cit0070","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01522-15"},{"key":"cit0071","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074163"},{"key":"cit0072","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.370"},{"key":"cit0073","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.354373"},{"key":"cit0074","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2022.128664"},{"key":"cit0075","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2020.115643"},{"key":"cit0076","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2020.127742"},{"key":"cit0077","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M303594200"},{"key":"cit0078","unstructured":"Gilead and boehringer ingelheim sign license agreement for novel HIV non-catalytic integrase inhibitors, Gilead HP. Press Releases[cited 2022 Oct 21]. Available from: https:\/\/www.gilead.com\/news-and-press\/press-room\/press-releases\/2011\/10\/gilead-and-boehringer-ingelheim-sign-license-agreement-for-novel-hiv\u2013non-catalytic-integrase-inhibitors"},{"key":"cit0079","unstructured":"Safety and pharmacokinetics of multiple rising oral doses of BI 224436 in healthy male volunteers. Clinicaltrials.gov [cited 2022 Oct 21]. Available from: https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT01276990"},{"key":"cit0080","unstructured":"ViiV HP. [cited 2022 Oct 21]. Available from: https:\/\/viivhealthcare.com\/"},{"key":"cit0081","unstructured":"Velthuisen EJ, Weath-Erhead JG. Indoline derivatives, WO2018020357A1. 2018"},{"key":"cit0082","unstructured":"Belema M, Bowsher MS, Deskus JA, et al. Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication, WO2018127800A1. 2018"},{"key":"cit0083","unstructured":"Bowsher MS, Deskus J, Eastman KJ, et al. Pyridin-3-yl acetic acid derivatives as inhibitors of human immunodeficiency virus replication, WO2018127801A1. 2018"},{"key":"cit0084","unstructured":"Cai ZR, Guo H, Ji M, et al. Benzothiazol-6-yl acetic acid derivatives and their use for treating hiv infection, WO2018064080A1. 2018"},{"key":"cit0085","doi-asserted-by":"publisher","DOI":"10.1021\/ja973109o"},{"key":"cit0086","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2016.0071"},{"key":"cit0087","unstructured":"Kim BJ, Lee IIIY, Kim JH, et al. Novel pyrrolopyridine derivative, method for producing same, and use thereof, WO2018174320A1. 2018"},{"key":"cit0088","unstructured":"HP STPHARM. STP0404 clinical trial, [cited 2022 Oct 21]. Available from: https:\/\/www.stpharm.co.kr\/en\/pr\/media-focus\/st-pharm-present-phase-1-clinical-trial-results-of-hiv-treatment-candidate-at-aids-2022"},{"key":"cit0089","volume-title":"Conference on Retroviruses and Opportunistic Infections (CROI)","author":"Ahn S","year":"2017"},{"key":"cit0090","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1004180"},{"key":"cit0091","doi-asserted-by":"publisher","DOI":"10.1097\/COH.0b013e328331d4b1"},{"key":"cit0092","doi-asserted-by":"publisher","DOI":"10.1021\/bi100130f"},{"key":"cit0093","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00157-11"},{"key":"cit0094","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2016.07.006"},{"key":"cit0095","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2015.1064896"},{"key":"cit0096","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2017.1360283"},{"key":"cit0097","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2018.1438410"},{"key":"cit0098","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddtec.2004.11.007"},{"key":"cit0099","unstructured":"Single Ascending Dose Trial Investigating Safety, Tolerability and Pharmacokinetics of BDM-2 in Healthy Male Subjects. Clinicaltrial gov BDM-2, [cited 2022 Oct 21]. Available from:https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT03634085"},{"key":"cit0100","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200418001-00004"},{"key":"cit0101","doi-asserted-by":"publisher","DOI":"10.7448\/IAS.16.3.18640"},{"key":"cit0102","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-020-03055-1"},{"key":"cit0103","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01917-w"},{"key":"cit0104","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1909512"},{"key":"cit0105","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00538-4"},{"key":"cit0106","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2020.06.003"},{"key":"cit0107","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2019.03.008"},{"key":"cit0108","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00424"},{"key":"cit0109","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.04.039"},{"key":"cit0110","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M209278200"},{"key":"cit0111","doi-asserted-by":"publisher","DOI":"10.1038\/nm1329"},{"key":"cit0112","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02328-20"},{"key":"cit0113","doi-asserted-by":"publisher","DOI":"10.1038\/nature07745"},{"key":"cit0114","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.5.1304"},{"key":"cit0115","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.5.1189"},{"key":"cit0116","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b00861"},{"key":"cit0117","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2020.127547"},{"key":"cit0118","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2018.10.008"},{"key":"cit0119","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2206104119"},{"key":"cit0120","unstructured":"Ishii A, Sato A, Kawai M, et al. Arenavirus growth inhibitor comprising polycyclic carbamoyl pyridone derivative. WO2020004443A1. 2020"}],"container-title":["Expert Opinion on Therapeutic Patents"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13543776.2023.2178300","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T14:48:44Z","timestamp":1677077324000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/13543776.2023.2178300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,2]]},"references-count":120,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1,2]]}},"alternative-id":["10.1080\/13543776.2023.2178300"],"URL":"https:\/\/doi.org\/10.1080\/13543776.2023.2178300","relation":{},"ISSN":["1354-3776","1744-7674"],"issn-type":[{"value":"1354-3776","type":"print"},{"value":"1744-7674","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,2]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ietp20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ietp20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2022-12-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}