{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:49:29Z","timestamp":1791920969249,"version":"4.3.4"},"reference-count":103,"publisher":"Informa UK Limited","issue":"4","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001322","name":"South African Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015777","name":"Division of Research Capacity Development","doi-asserted-by":"publisher","award":["Bongani Mayosi National Health Scholars Programme"],"award-info":[{"award-number":["Bongani Mayosi National Health Scholars Programme"]}],"id":[{"id":"10.13039\/501100015777","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Therapeutic Patents"],"published-print":{"date-parts":[[2024,4,2]]},"DOI":"10.1080\/13543776.2024.2363890","type":"journal-article","created":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T05:01:28Z","timestamp":1718341288000},"page":"273-295","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":11,"title":["HDAC3 inhibitors: a patent review of their broad-spectrum applications as therapeutic agents"],"prefix":"10.1080","volume":"34","author":[{"given":"Thabo Brighton","family":"Makgoba","sequence":"first","affiliation":[{"name":"Pharmaceutical Chemistry, School of Pharmacy, University of the Western Cape, Bellville, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Kapp","sequence":"additional","affiliation":[{"name":"Pharmaceutical Chemistry, School of Pharmacy, University of the Western Cape, Bellville, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Egieyeh","sequence":"additional","affiliation":[{"name":"Pharmaceutical Chemistry, School of Pharmacy, University of the Western Cape, Bellville, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Joubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.31254\/jmr.2022.8506"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X18666200128125641"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.22045\/ibj.2016.01"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj0870258"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.672447"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026615666150825125857"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/47412"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370220928278"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112171"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2020.01.015"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/embo-reports\/kvf053"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2019.11.007"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000505535"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2019.04.010"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M402229200"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2019.01.004"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/143269"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2023.2192804"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568009617666170630124643"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2010.02.030"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-020-0382-4"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.05.047"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-18-1068"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2023.109633"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.107400"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1213364110"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2017.00065"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12642"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1805436115"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152498"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8520856"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1495-3"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-2640118\/v1"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2576-2"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2799-18.2019"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X13666151021111609"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20010051"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevEukaryotGeneExpr.2020034380"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-023-01399-w"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.62.10.14"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6086780"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.121574"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-20879\/v1"},{"key":"e_1_3_4_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2018.1459568"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00537"},{"key":"e_1_3_4_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2017.1417274"},{"key":"e_1_3_4_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14889"},{"key":"e_1_3_4_50_1","doi-asserted-by":"publisher","DOI":"10.4068\/cmj.2016.52.1.1"},{"key":"e_1_3_4_51_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-0799"},{"key":"e_1_3_4_52_1","doi-asserted-by":"publisher","DOI":"10.1089\/biores.2012.0223"},{"key":"e_1_3_4_53_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1006489328324"},{"key":"e_1_3_4_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdh438"},{"key":"e_1_3_4_55_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M807045200"},{"key":"e_1_3_4_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.1c00702"},{"key":"e_1_3_4_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2011.08.004"},{"key":"e_1_3_4_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23030551"},{"key":"e_1_3_4_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.01.077"},{"key":"e_1_3_4_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.10.072"},{"key":"e_1_3_4_61_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01676"},{"key":"e_1_3_4_62_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068669"},{"key":"e_1_3_4_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.0c00721"},{"key":"e_1_3_4_64_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008825"},{"key":"e_1_3_4_65_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20070779"},{"key":"e_1_3_4_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24260"},{"key":"e_1_3_4_67_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-1461"},{"key":"e_1_3_4_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.527"},{"key":"e_1_3_4_69_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.38.9411"},{"key":"e_1_3_4_70_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.43.7251"},{"key":"e_1_3_4_71_1","unstructured":"Zhang J Li S Wang B. Medicament for treating tumors. CN101979090. 2010. https:\/\/patents.google.com\/patent\/CN101979090B\/en?oq=CN101979090B"},{"key":"e_1_3_4_72_1","unstructured":"Tesar PJ Clayton BLL. Treatment of neurodegenerative diseases with HDAC inhibitors. WO2023034440A1. 2023. https:\/\/patents.google.com\/patent\/WO2023034440A1\/en?oq=WO2023034440A1"},{"key":"e_1_3_4_73_1","unstructured":"He X Lu Q Zhang L. Methods of treating diseases and nerve injuries. WO2019032652A1. 2019. https:\/\/patents.google.com\/patent\/WO2019032652A1\/en?oq=WO2019032652A1."},{"key":"e_1_3_4_74_1","unstructured":"Kai W Rong ET. Compositions and methods using an epigenetic inhibitor. US20190358265. 2018. https:\/\/patents.google.com\/patent\/US20190358265A1\/en?oq=US20190358265."},{"key":"e_1_3_4_75_1","unstructured":"Mi Q-S Zhou L. HDAC3 inhibitors for the treatment of Langerhans cell histiocytosis and Langerhans cell sarcoma. WO2023049798A1. 2023. https:\/\/patents.google.com\/patent\/WO2023049798A1\/en?oq=WO2023049798A1"},{"key":"e_1_3_4_76_1","unstructured":"Le W Yang J Tang Y. Method for preparing nerve precursor cells by using pluripotent stem cells. CN105624116. 2016. https:\/\/patents.google.com\/patent\/CN105624116A\/en?oq=CN105624116."},{"key":"e_1_3_4_77_1","unstructured":"Wood MA. Method and therapeutic for the treatment and regulation of memory formation. US20130210899A1. 2013. https:\/\/patents.google.com\/patent\/US20130210899A1\/en?oq=US20130210899A1"},{"key":"e_1_3_4_78_1","unstructured":"Zhou X Yang L. Drug for promoting recovery from chronic spinal cord injury and preparation method and application thereof. CN110833543. 2020. https:\/\/patents.google.com\/patent\/CN110833543A\/en?oq=CN110833543"},{"key":"e_1_3_4_79_1","unstructured":"Duzer JHV Mazitschek R. Selective HDAC3 inhibitors. US20140243345A1. 2014. https:\/\/patents.google.com\/patent\/US20140243345A1\/en?oq=US20140243345A1"},{"key":"e_1_3_4_80_1","unstructured":"Jacques V Rusche JR. HDAC inhibitors. US20180362472A1. 2018. https:\/\/patents.google.com\/patent\/US20180362472A1\/en?oq=US20180362472A1"},{"key":"e_1_3_4_81_1","unstructured":"Bhagwat S Luedtke G. Histone deacetylase inhibitors. AU2017382331A1. 2019. https:\/\/patents.google.com\/patent\/AU2017382331A1\/en?oq=AU2017382331A1"},{"key":"e_1_3_4_82_1","unstructured":"Balaram G Swati B Routholla G et al. Benzamide based HDAC3 selective inhibitors. IN202011056177. 2022. https:\/\/patentscope.wipo.int\/search\/en\/detail.jsf?docId=IN367112223&_cid=P21-LUMHKK-63515-1"},{"key":"e_1_3_4_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.105050"},{"key":"e_1_3_4_84_1","unstructured":"Balaram G Swati B Routholla G et al. Hydrazide based HDAC3 selective inhibitors. IN202111022553. 2023. https:\/\/patentscope.wipo.int\/search\/en\/detail.jsf?docId=IN393725717&_cid=P21-LUMHLL-64645-1"},{"key":"e_1_3_4_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114470"},{"key":"e_1_3_4_86_1","unstructured":"Li D Park P Qi J et al. HDAC3 catalytic inhibitor development and uses thereof. US20220227700. 2020. https:\/\/patents.google.com\/patent\/US20220227700A1\/en?oq=US20220227700"},{"key":"e_1_3_4_87_1","unstructured":"Holson E Wagner FF Haggarty SJ et al. Inhibitors of histone deacetylase. US11377423B2. 2022. https:\/\/patents.google.com\/patent\/US11377423B2\/en?oq=US11377423B2."},{"key":"e_1_3_4_88_1","unstructured":"Mazitschek R Hideshima T Anderson KC et al. Inhibitors of histone deacetylase. USRE49240E1. 2022. https:\/\/patents.google.com\/patent\/USRE49240E1\/en?oq=USRE49240E1"},{"key":"e_1_3_4_89_1","unstructured":"Holson E Nacht M. Combination of a selective histone deacetylase 3 (hdac3) inhibitor and an immunotherapy agent for the treatment of cancer. US20210177781A9. 2021. https:\/\/patents.google.com\/patent\/US20210177781A9\/en?oq=US20210177781A9"},{"key":"e_1_3_4_90_1","unstructured":"Miyata N Suzuki T Kasuya Y. Novel amide compound and application thereof. JP2013170164. 2013. https:\/\/patents.google.com\/patent\/JP2013170164A\/en?oq=JP2013170164+"},{"key":"e_1_3_4_91_1","unstructured":"Chen C-S Hsieh H-Y Chuang H-C. Hdac3-selective inhibitors. WO2018223122A1. 2018. https:\/\/patents.google.com\/patent\/WO2018223122A1\/en?oq=WO2018223122A1"},{"key":"e_1_3_4_92_1","unstructured":"Cooper A Rusche JR. Methods of identifying histone deacetylase inhibitors useful for neurological disorders. EP2214483. 2010. https:\/\/patents.google.com\/patent\/EP2214483A1\/en?oq=EP2214483"},{"key":"e_1_3_4_93_1","unstructured":"Jacques V Rusche JR Peet NP et al. Histone deacetylase inhibitors. US20180370987A1. 2018. https:\/\/patents.google.com\/patent\/US20180370987A1\/en?oq=US20180370987A1"},{"key":"e_1_3_4_94_1","unstructured":"Shen J Xiong B Zhao L et al. Histone deacetylase inhibitor and application thereof. CN107879975. 2018. https:\/\/patents.google.com\/patent\/CN107879975A\/en?oq=CN107879975"},{"key":"e_1_3_4_95_1","unstructured":"Liu D Zhao L Xu Q et al. PSA derivatives with HDAC3 inhibitory activity and application thereof. CN111548286. 2020. https:\/\/patents.google.com\/patent\/CN111548286A\/en?oq=CN111548286"},{"key":"e_1_3_4_96_1","unstructured":"Liu D Zhao L Cheng G et al. Phenylpyrazole compound and application. CN113754587. 2021. https:\/\/patents.google.com\/patent\/CN113754587A\/en?oq=CN113754587."},{"key":"e_1_3_4_97_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20010051"},{"key":"e_1_3_4_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-05698-7"},{"key":"e_1_3_4_99_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0CC03243C"},{"key":"e_1_3_4_100_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2018.1477625"},{"key":"e_1_3_4_101_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27082526"},{"key":"e_1_3_4_102_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18010137"},{"key":"e_1_3_4_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/minf.202000105"},{"key":"e_1_3_4_104_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2018.1437156"},{"key":"e_1_3_4_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10728"}],"container-title":["Expert Opinion on Therapeutic Patents"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13543776.2024.2363890","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T22:15:47Z","timestamp":1727216147000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/13543776.2024.2363890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,2]]},"references-count":103,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4,2]]}},"alternative-id":["10.1080\/13543776.2024.2363890"],"URL":"https:\/\/doi.org\/10.1080\/13543776.2024.2363890","relation":{},"ISSN":["1354-3776","1744-7674"],"issn-type":[{"value":"1354-3776","type":"print"},{"value":"1744-7674","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,2]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ietp20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ietp20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2024-02-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}