{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T16:07:43Z","timestamp":1789056463039,"version":"build-2803163510"},"reference-count":103,"publisher":"Informa UK Limited","issue":"11","license":[{"start":{"date-parts":[[2024,10,6]],"date-time":"2024-10-06T00:00:00Z","timestamp":1728172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1080\/policies-text-data-mining"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Therapeutic Patents"],"published-print":{"date-parts":[[2024,11,1]]},"DOI":"10.1080\/13543776.2024.2412575","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T01:35:35Z","timestamp":1727919335000},"page":"1121-1135","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":9,"title":["A patent review of lactate dehydrogenase inhibitors (2014\u2013present)"],"prefix":"10.1080","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4336-4344","authenticated-orcid":false,"given":"Giulia","family":"Bononi","sequence":"first","affiliation":[{"name":"University of Pisa","place":["Pisa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6126-9984","authenticated-orcid":false,"given":"Valeria","family":"Di Bussolo","sequence":"additional","affiliation":[{"name":"University of Pisa","place":["Pisa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6205-4069","authenticated-orcid":false,"given":"Tiziano","family":"Tuccinardi","sequence":"additional","affiliation":[{"name":"University of Pisa","place":["Pisa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3312-104X","authenticated-orcid":false,"given":"Filippo","family":"Minutolo","sequence":"additional","affiliation":[{"name":"University of Pisa","place":["Pisa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5849-0722","authenticated-orcid":false,"given":"Carlotta","family":"Granchi","sequence":"additional","affiliation":[{"name":"University of Pisa","place":["Pisa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2024,10,6]]},"reference":[{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101339"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986710790416263"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2022.11.007"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.2164\/jandrol.109.008367"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0134(20010501)43:2<175::AID-PROT1029>3.0.CO;2-#"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm101007q"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1275000"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2022.12.001"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00168"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.4155\/ppa-2020-0025"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2012.04.028"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/2525967"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2981"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.12.006"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.181016"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.11.010"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-015-2070-4"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.123.3191.309"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2022.07.003"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-008-9955-5"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601205"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2022.09.001"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.7637"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2007.07.006"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/pore.2021.1609951"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.004180"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2143"},{"key":"e_1_3_5_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2009.11.022"},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2023.105253"},{"key":"e_1_3_5_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-43761-y"},{"key":"e_1_3_5_33_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/481405"},{"key":"e_1_3_5_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2022.2106179"},{"key":"e_1_3_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119080"},{"key":"e_1_3_5_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.28480"},{"key":"e_1_3_5_37_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.104.008177"},{"key":"e_1_3_5_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2016.10.490"},{"key":"e_1_3_5_39_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/234572"},{"key":"e_1_3_5_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007020050174"},{"key":"e_1_3_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2005.06.010"},{"key":"e_1_3_5_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.12.028"},{"key":"e_1_3_5_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-11-57"},{"key":"e_1_3_5_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-021-00543-4"},{"key":"e_1_3_5_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2019.08.025"},{"key":"e_1_3_5_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-6851(97)00140-0"},{"key":"e_1_3_5_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.12.013"},{"key":"e_1_3_5_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2012.08.012"},{"key":"e_1_3_5_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-014-0672-8"},{"key":"e_1_3_5_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.7b01668"},{"key":"e_1_3_5_51_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.935054"},{"key":"e_1_3_5_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2154"},{"key":"e_1_3_5_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/cc060110n"},{"key":"e_1_3_5_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(01)00636-0"},{"key":"e_1_3_5_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.11.031"},{"key":"e_1_3_5_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep15556"},{"key":"e_1_3_5_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2011.10.031"},{"key":"e_1_3_5_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201300562"},{"key":"e_1_3_5_59_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm201734r"},{"key":"e_1_3_5_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/2049-3002-1-19"},{"key":"e_1_3_5_61_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c07569"},{"key":"e_1_3_5_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b00941"},{"key":"e_1_3_5_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.6b00190"},{"key":"e_1_3_5_64_1","unstructured":"Hoffmann La Roche; Genentech Inc. Piperidine-dione derivatives. WO2015140133A1. 2015."},{"key":"e_1_3_5_65_1","unstructured":"Genentech Inc; Hoffmann La Roche. Method of controlling lactate production with piperdine-dione derivatives. WO2015142903A2. 2015."},{"key":"e_1_3_5_66_1","unstructured":"US Health; University Vanderbilt. Small molecule inhibitors of lactate dehydrogenase and methods of use thereof. WO2016109559A2. 2016."},{"key":"e_1_3_5_67_1","unstructured":"US Health; University Vanderbilt; UAB Research Foundation; University Pennsylvania. 1H-pyrazol-1-yl-thiazoles as inhibitors of lactate dehydrogenase and methods of use thereof. WO2018005807A1. 2018."},{"key":"e_1_3_5_68_1","unstructured":"Chinook Therapeutics Canada Inc. Substituted pyrazolyl compounds and methods of use thereof. WO2021234543A1. 2021."},{"key":"e_1_3_5_69_1","unstructured":"Chinook Therapeutics Canada Inc. Substituted pyrazolyl compounds and methods of use thereof. WO2021234547A1. 2021."},{"key":"e_1_3_5_70_1","unstructured":"University Vanderbilt; UAB Research Foundation; US Health. Treating primary or idiopathic hyperoxaluria with small molecule inhibitors of lactate dehydrogenase. US20210369683A1. 2021."},{"key":"e_1_3_5_71_1","unstructured":"US Health. T cells having enhanced anti-tumor activity. WO2021026290A1. 2021."},{"key":"e_1_3_5_72_1","unstructured":"Selvita SA. Pyrazolidine derivatives and related compounds. WO2017055396A1. 2017."},{"key":"e_1_3_5_73_1","unstructured":"National University Corporation Okayama University. Lactic acid dehydrogenase inhibitor and pharmaceutical preparation containing same. WO2014115764A1. 2014."},{"key":"e_1_3_5_74_1","unstructured":"National University Corporation Okayama University. Lactate dehydrogenase inhibitor and antiepileptic drug containing same. WO2016129583A1. 2016."},{"key":"e_1_3_5_75_1","unstructured":"National University Corporation Okayama University. Novel stiripentol derivative and use there of. WO2022025242A1. 2022."},{"key":"e_1_3_5_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-019-01204-y"},{"key":"e_1_3_5_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-024-02813-0"},{"key":"e_1_3_5_78_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa1299"},{"key":"e_1_3_5_79_1","unstructured":"Pusan National University Industry-University Cooperation Foundation; Amcobio Inc. A composition for anti-cancer comprising 2-phenylthiobenzo[d]thiazole derivatives. KR20220006305A. 2022."},{"key":"e_1_3_5_80_1","unstructured":"Meta Pharmaceutical Hk Ltd. Quinoline compound and use thereof. WO2023138675A1. 2023."},{"key":"e_1_3_5_81_1","unstructured":"Glaxosmithkline Llc; Brown Kristin K; Chai Deping; Dodson Christopher S; Duffy Kevin J; Shaw Antony Nicholas. Chemical compounds. WO2013096153A1. 2013."},{"key":"e_1_3_5_82_1","unstructured":"Federal State Budgetary Educational Institution of Higher Education Moscow. Use of sulfonates for inhibiting human lactate dehydrogenase a. RU2751003C1. 2021."},{"key":"e_1_3_5_83_1","unstructured":"Theodossiou Theodossis. 5-aminolevulinic acid or an ester thereof for use in treatment of cancer based on the inhibition of lactate dehydrogenase. EP4306108A1. 2022."},{"key":"e_1_3_5_84_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14164003"},{"key":"e_1_3_5_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40475-015-0056-9"},{"key":"e_1_3_5_86_1","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2023.2160704"},{"key":"e_1_3_5_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)70772-8"},{"key":"e_1_3_5_88_1","unstructured":"University of Illinois; Witola William Harold; Li Kun. Compounds and methods for the treatment of parasitic infections. WO2020247758A1. 2020."},{"key":"e_1_3_5_89_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24044004"},{"key":"e_1_3_5_90_1","unstructured":"Kottmann Robert M; Sime Patricia J; Phipps Richard P; University of Rochester. LDH inhibitors as treatment for fibrosis and fibrotic-related disorders. US20150335674A1. 2015."},{"key":"e_1_3_5_91_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.503540"},{"key":"e_1_3_5_92_1","unstructured":"Harbin Medical University at Daqing Branch. Application of LDHA inhibitor in preparation of medicine for treating pulmonary arterial hypertension. CN116421591A. 2023."},{"issue":"3","key":"e_1_3_5_93_1","first-page":"162","article-title":"Porcine reproductive and respiratory syndrome virus (PRRSV) in pig meat","volume":"81","author":"Raymond P","year":"2017","unstructured":"Raymond P, Bellehumeur C, Nagarajan M, et al. Porcine reproductive and respiratory syndrome virus (PRRSV) in pig meat. Can J Vet Res. 2017;81(3):162\u2013170.","journal-title":"Can J Vet Res"},{"key":"e_1_3_5_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.09.013"},{"key":"e_1_3_5_95_1","unstructured":"Nanjing Agricultural University. Application of glycolysis inhibitor in preparation of medicines for preventing and treating porcine reproductive and respiratory syndrome virus infection. WO2022000571A1. 2022."},{"key":"e_1_3_5_96_1","unstructured":"Research Foundation For Suny. Compositions and methods for inhibiting lacate dehydrogenase a activity. US2020407397A1. 2020."},{"key":"e_1_3_5_97_1","unstructured":"University Catholique Louvain. Lactate dehydrogenase inhibitor polypeptides for use in the treatment of cancer. WO2020221899A1. 2020."},{"key":"e_1_3_5_98_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.111.091546"},{"key":"e_1_3_5_99_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.139.3555.601"},{"key":"e_1_3_5_100_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103879"},{"key":"e_1_3_5_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2019.11.032"},{"key":"e_1_3_5_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.12.002"},{"key":"e_1_3_5_103_1","unstructured":"Qatar Foundation Education Science & Community Development. Targeting of lactate dehydrogenase C methods of preparing same and methods of using same in combination with anti-cancer treatments. WO2021251842A1. 2021."},{"key":"e_1_3_5_104_1","unstructured":"MedChemExpress China Co Ltd. Synthesizing method of key intermediate for synthesizing lactate dehydrogenase a (LDHA) inhibitor. CN109369631A. 2019."},{"key":"e_1_3_5_105_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-023-01976-4"}],"container-title":["Expert Opinion on Therapeutic Patents"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13543776.2024.2412575","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/full-xml\/10.1080\/13543776.2024.2412575","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13543776.2024.2412575","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:22:31Z","timestamp":1789053751000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/13543776.2024.2412575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,6]]},"references-count":103,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11,1]]}},"alternative-id":["10.1080\/13543776.2024.2412575"],"URL":"https:\/\/doi.org\/10.1080\/13543776.2024.2412575","relation":{},"ISSN":["1354-3776","1744-7674"],"issn-type":[{"value":"1354-3776","type":"print"},{"value":"1744-7674","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,6]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ietp20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ietp20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2024-06-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}