{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T10:42:36Z","timestamp":1768732956370,"version":"3.49.0"},"reference-count":169,"publisher":"Informa UK Limited","issue":"6","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Therapeutic Patents"],"published-print":{"date-parts":[[2025,6,3]]},"DOI":"10.1080\/13543776.2025.2477475","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T23:44:57Z","timestamp":1742773497000},"page":"543-569","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":2,"title":["A patent review of CXCR7 modulators (2019-present)"],"prefix":"10.1080","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5575-8896","authenticated-orcid":false,"given":"Thanigaimalai","family":"Pillaiyar","sequence":"first","affiliation":[{"name":"Eberhard Karls University T\u00fcbingen","place":["T\u00fcbingen, Germany"]},{"name":"Eberhard Karls University T\u00fcbingen","place":["T\u00fcbingen, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6952-1486","authenticated-orcid":false,"given":"Stefan","family":"Laufer","sequence":"additional","affiliation":[{"name":"Eberhard Karls University T\u00fcbingen","place":["T\u00fcbingen, Germany"]},{"name":"Eberhard Karls University T\u00fcbingen","place":["T\u00fcbingen, Germany"]},{"name":"Eberhard Karls University T\u00fcbingen","place":["T\u00fcbingen, Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2025,4,4]]},"reference":[{"key":"e_1_3_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.178"},{"key":"e_1_3_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202004433"},{"key":"e_1_3_7_5_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20052144"},{"key":"e_1_3_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3544"},{"key":"e_1_3_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2022.09.009"},{"key":"e_1_3_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105092"},{"key":"e_1_3_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dci.2011.01.019"},{"key":"e_1_3_7_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00379"},{"key":"e_1_3_7_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.591386"},{"key":"e_1_3_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-6997(24)01439-X"},{"key":"e_1_3_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2005.05.003"},{"key":"e_1_3_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2812"},{"key":"e_1_3_7_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0912852107"},{"key":"e_1_3_7_16_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.18.1.217"},{"key":"e_1_3_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2012.04.004"},{"key":"e_1_3_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2022.09.009"},{"key":"e_1_3_7_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242216493"},{"key":"e_1_3_7_20_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201488887"},{"key":"e_1_3_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10519-014-9665-7"},{"key":"e_1_3_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2014.07.012"},{"key":"e_1_3_7_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00224"},{"key":"e_1_3_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2011.01.012"},{"key":"e_1_3_7_25_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20120246"},{"key":"e_1_3_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-391862-8.00008-9"},{"key":"e_1_3_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2012.08.003"},{"key":"e_1_3_7_28_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20052144"},{"key":"e_1_3_7_29_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M508234200"},{"key":"e_1_3_7_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009175"},{"key":"e_1_3_7_31_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.335679"},{"key":"e_1_3_7_32_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.69.022405.154749"},{"key":"e_1_3_7_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M707465200"},{"key":"e_1_3_7_34_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.062810"},{"key":"e_1_3_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25245"},{"key":"e_1_3_7_36_1","doi-asserted-by":"publisher","DOI":"10.1158\/00085472.CAN-09-3642"},{"key":"e_1_3_7_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.5.1681"},{"key":"e_1_3_7_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1675"},{"key":"e_1_3_7_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1182"},{"key":"e_1_3_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.07.039"},{"key":"e_1_3_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12176"},{"key":"e_1_3_7_42_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20102010"},{"key":"e_1_3_7_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2889"},{"key":"e_1_3_7_44_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.5.3353"},{"key":"e_1_3_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107951"},{"key":"e_1_3_7_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201343907"},{"key":"e_1_3_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.12.006"},{"key":"e_1_3_7_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21780"},{"key":"e_1_3_7_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201100581"},{"key":"e_1_3_7_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c01198"},{"key":"e_1_3_7_51_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020680"},{"key":"e_1_3_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.08.040"},{"key":"e_1_3_7_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-023-00854-6"},{"key":"e_1_3_7_54_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.82317"},{"key":"e_1_3_7_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.906586"},{"key":"e_1_3_7_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00590"},{"key":"e_1_3_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2015.07.002"},{"key":"e_1_3_7_58_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.118.115279"},{"key":"e_1_3_7_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.633"},{"key":"e_1_3_7_60_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0187357"},{"key":"e_1_3_7_61_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.2MR0815-383R"},{"key":"e_1_3_7_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2014.04.006"},{"key":"e_1_3_7_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(03)14232-8"},{"key":"e_1_3_7_64_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.21-3-363"},{"key":"e_1_3_7_65_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci17902"},{"key":"e_1_3_7_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/31261"},{"key":"e_1_3_7_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/382635a0"},{"key":"e_1_3_7_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600221"},{"key":"e_1_3_7_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2012.04.009"},{"key":"e_1_3_7_70_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.465.65.2"},{"key":"e_1_3_7_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31237"},{"key":"e_1_3_7_72_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.74.2.619-626.2000"},{"key":"e_1_3_7_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2018.e00557"},{"key":"e_1_3_7_74_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-017-0765-1"},{"key":"e_1_3_7_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12870"},{"key":"e_1_3_7_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12870"},{"key":"e_1_3_7_77_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-249730"},{"key":"e_1_3_7_78_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.305171"},{"key":"e_1_3_7_79_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20150113"},{"key":"e_1_3_7_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.17294"},{"key":"e_1_3_7_81_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.14327"},{"key":"e_1_3_7_82_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c01371"},{"key":"e_1_3_7_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16664-0"},{"key":"e_1_3_7_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00548-w"},{"key":"e_1_3_7_85_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00641"},{"key":"e_1_3_7_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.830"},{"key":"e_1_3_7_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.503"},{"key":"e_1_3_7_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.482"},{"key":"e_1_3_7_89_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr3665"},{"key":"e_1_3_7_90_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.070918"},{"key":"e_1_3_7_91_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2008.512"},{"key":"e_1_3_7_92_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20102010"},{"key":"e_1_3_7_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27650"},{"key":"e_1_3_7_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.482"},{"key":"e_1_3_7_95_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601682"},{"key":"e_1_3_7_96_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12881"},{"key":"e_1_3_7_97_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0702229104"},{"key":"e_1_3_7_98_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00190"},{"key":"e_1_3_7_99_1","doi-asserted-by":"publisher","DOI":"10.2174\/138945012799201603"},{"key":"e_1_3_7_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2017.09.001"},{"key":"e_1_3_7_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-2052-9"},{"key":"e_1_3_7_102_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00779"},{"key":"e_1_3_7_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2018.29"},{"key":"e_1_3_7_104_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-2636"},{"key":"e_1_3_7_105_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S195661"},{"key":"e_1_3_7_106_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786"},{"key":"e_1_3_7_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2012.04.007"},{"key":"e_1_3_7_108_1","doi-asserted-by":"publisher","DOI":"10.2147\/vhrm.2006.2.3.213"},{"key":"e_1_3_7_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/423593a"},{"key":"e_1_3_7_110_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13347"},{"key":"e_1_3_7_111_1","doi-asserted-by":"publisher","DOI":"10.1684\/ecn.2007.0087"},{"key":"e_1_3_7_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.09.076"},{"issue":"22","key":"e_1_3_7_113_1","first-page":"5830","article-title":"Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases","volume":"59","author":"Zhong H","year":"1999","unstructured":"Zhong H, De Marzo AM, Laughner E, et al. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res. 1999;59(22):5830\u20135835. Available from: http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10582706","journal-title":"Cancer Res"},{"key":"e_1_3_7_114_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0610444104"},{"key":"e_1_3_7_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2019.11.004"},{"key":"e_1_3_7_116_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr3074"},{"key":"e_1_3_7_117_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-019-0780-x"},{"key":"e_1_3_7_118_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.8286"},{"key":"e_1_3_7_119_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6125"},{"key":"e_1_3_7_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605078"},{"key":"e_1_3_7_121_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnase2015433118"},{"key":"e_1_3_7_122_1","unstructured":"Guerry P Vao Raumer M. Crystalline forms of the cxcr7 receptor antagonist (3s 4s)-1- cyclopropylmethyl-4-{[5-(2 4-difluoro-phenyl)-isoxazole-3-carbonyl]-amino}-piperidine-3-carboxylic acid (1-pyrimidin-2-yl-cyclopropyl)-amide. WO2019\/145460A1. Available from: https:\/\/patents.google.com\/patent\/WO2019145460A1\/en?oq=WO+2019%2f145460+A1annotation"},{"key":"e_1_3_7_123_1","unstructured":"Aissaoui H Guerry P Lehembre F et al. Piperidine cxcr7 receptor modulators. WO2018019929A1. Available from: https:\/\/patents.google.com\/patent\/WO2018019929A1\/en?oq=WO2018019929A1"},{"key":"e_1_3_7_124_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01588"},{"key":"e_1_3_7_125_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202002465R"},{"key":"e_1_3_7_126_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.748740"},{"issue":"2236","key":"e_1_3_7_127_1","article-title":"CXCR7 antagonism with ACT-1004\u20131239 reduces neuroinflammation and accelerates remyelination in murine demyelinating models","volume":"96","author":"Pouzol L","year":"2021","unstructured":"Pouzol L, Tunis M, Baumlin N, et al. CXCR7 antagonism with ACT-1004\u20131239 reduces neuroinflammation and accelerates remyelination in murine demyelinating models. Neurology. 2021;96(2236). Available from: http:\/\/n.neurology.org\/content\/96\/15_Supplement\/2236.abstract","journal-title":"Neurology"},{"key":"e_1_3_7_128_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2154"},{"key":"e_1_3_7_129_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.812065"},{"key":"e_1_3_7_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112363"},{"key":"e_1_3_7_131_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21332"},{"key":"e_1_3_7_132_1","unstructured":"Gotoh N Campbell JJ. CXCR7 inhibitors for the treatment of cancer. WO2020123582A1. Available from: https:\/\/patents.google.com\/patent\/WO2020123582A1\/en?oq=WO+2020%2f123582+Al"},{"key":"e_1_3_7_133_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-016-5180-1"},{"key":"e_1_3_7_134_1","unstructured":"Fan J Krasinski A Lange CW et al. CXCR7 antagonists. WO2014085490A1. Available from: https:\/\/patents.google.com\/patent\/WO2014085490A1\/en?oq=WO2014085490+A1"},{"key":"e_1_3_7_135_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2011.118398"},{"key":"e_1_3_7_136_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20131224"},{"key":"e_1_3_7_137_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0468-4"},{"key":"e_1_3_7_138_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-015-9616-y"},{"key":"e_1_3_7_139_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-024-04173-1"},{"key":"e_1_3_7_140_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.13883"},{"key":"e_1_3_7_141_1","unstructured":"Pouzol L. Combination of a CXCR7 antagonist with an S1P1 receptor modulator. WO2021084068A1. Available from: https:\/\/patents.google.com\/patent\/WO2021084068A1\/en?oq=WO2021084068"},{"key":"e_1_3_7_142_1","unstructured":"Pingchen F Lange CW Lui RM et al. Preparation of azetidinyl-acetamides as CXCR7 inhibitors for the treatment of diseases. WO2022225832. Available from: https:\/\/patents.google.com\/patent\/WO2022225832A1\/en?oq=WO2022225832+"},{"key":"e_1_3_7_143_1","unstructured":"Riemens R Bosma R Leurs R et al. Modulators of ackr3 and uses thereof. WO 2023\/166190Al. Available from: https:\/\/patents.google.com\/patent\/WO2023166190A1\/en?oq=WO+2023%2f166190+Al"},{"key":"e_1_3_7_144_1","unstructured":"Riemens R Bosma R Arimont Segura M et al. Quinazoline derivatives useful as modulators of ackr3. WO2022148879A1. Available from: https:\/\/patents.google.com\/patent\/WO2022148879A1\/en"},{"key":"e_1_3_7_145_1","doi-asserted-by":"publisher","DOI":"10.1124\/molpharm.123.000835"},{"key":"e_1_3_7_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(73)90196-2"},{"key":"e_1_3_7_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(97)90645-3"},{"key":"e_1_3_7_148_1","unstructured":"Pingchen F Lange CW Rebecca M et al. Preparation of azetidinyl-acetamides as CXCR7 inhibitors for the treatment of diseases. WO 2022\/225832. Available from: https:\/\/patents.google.com\/patent\/WO2022225832A1\/en?oq=WO+2022%2f225832+Al+"},{"key":"e_1_3_7_149_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026043451618"},{"key":"e_1_3_7_150_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00005.2009"},{"key":"e_1_3_7_151_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.110.003145"},{"key":"e_1_3_7_152_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.1999.03049.x"},{"key":"e_1_3_7_153_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318238bba6"},{"key":"e_1_3_7_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3858"},{"key":"e_1_3_7_155_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.102327699"},{"key":"e_1_3_7_156_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200737630"},{"key":"e_1_3_7_157_1","unstructured":"Meyrath M Szpakowsk M Chevign\u00e9 A. Novel selective ackr3 modulators and uses thereof WO 2020\/225070 Al. https:\/\/patents.google.com\/patent\/WO2020225070A1\/en?oq=WO+2020%2f225070+Al."},{"key":"e_1_3_7_158_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00190"},{"key":"e_1_3_7_159_1","unstructured":"Chevign\u00e9 A Szpakowska M Namjoshi O et al. Bruce Conolidine analogues as selective ackr3 modulators for the treatment of cancer and cardiovascular diseases. WO 2022\/136486 Al. https:\/\/patents.google.com\/patent\/WO2022136486A1\/en?oq=WO+2022%2f136486+Al68A ."},{"key":"e_1_3_7_160_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14132"},{"key":"e_1_3_7_161_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.1c00006"},{"key":"e_1_3_7_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.10.052"},{"key":"e_1_3_7_163_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph13020033"},{"key":"e_1_3_7_164_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.0c00163"},{"key":"e_1_3_7_165_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00216"},{"key":"e_1_3_7_166_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.498436"},{"key":"e_1_3_7_167_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.167932"},{"key":"e_1_3_7_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2018.02.030"},{"key":"e_1_3_7_169_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-03-493924"},{"key":"e_1_3_7_170_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.467969"},{"key":"e_1_3_7_171_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00657"}],"container-title":["Expert Opinion on Therapeutic Patents"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13543776.2025.2477475","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T03:03:23Z","timestamp":1748833403000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/13543776.2025.2477475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,4]]},"references-count":169,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6,3]]}},"alternative-id":["10.1080\/13543776.2025.2477475"],"URL":"https:\/\/doi.org\/10.1080\/13543776.2025.2477475","relation":{},"ISSN":["1354-3776","1744-7674"],"issn-type":[{"value":"1354-3776","type":"print"},{"value":"1744-7674","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,4]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ietp20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ietp20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2024-09-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}