{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T06:56:23Z","timestamp":1769756183833,"version":"3.49.0"},"reference-count":86,"publisher":"Informa UK Limited","issue":"9","funder":[{"DOI":"10.13039\/501100004681","name":"Higher Education Commission, Pakistan","doi-asserted-by":"publisher","award":["P2\u2013345"],"award-info":[{"award-number":["P2\u2013345"]}],"id":[{"id":"10.13039\/501100004681","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Therapeutic Patents"],"published-print":{"date-parts":[[2025,9,2]]},"DOI":"10.1080\/13543776.2025.2547036","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T22:01:23Z","timestamp":1754949683000},"page":"947-962","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":2,"title":["GPR120 agonists for the treatment of type 2 diabetes: an updated patent review (2020-present)"],"prefix":"10.1080","volume":"35","author":[{"given":"Kainat","family":"Ilyas","sequence":"first","affiliation":[{"name":"COMSATS University Islamabad","place":["Abbottabad, Pakistan"]},{"name":"Government College University","place":["Faisalabad, Pakistan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ismat","family":"Nawaz","sequence":"additional","affiliation":[{"name":"COMSATS University Islamabad","place":["Abbottabad, Pakistan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanwal","family":"Rehman","sequence":"additional","affiliation":[{"name":"The Women University","place":["Multan, Pakistan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamshed","family":"Iqbal","sequence":"additional","affiliation":[{"name":"COMSATS University Islamabad","place":["Abbottabad, Pakistan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2025,8,17]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22147644"},{"key":"e_1_3_4_3_1","unstructured":"International Diabetes Federation. Diabetes facts & figures. 2025 [cited 2025 May 7]. Available from: https:\/\/idf.org\/about-diabetes\/diabetes-facts-figures\/"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01607"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.12.013"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v14.i3.130"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.346312.120"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.15773"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2017.04.007"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izad161"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.obmed.2022.100466"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16177"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2016.05.001"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01803-6"},{"key":"e_1_3_4_15_1","unstructured":"Bozorgpour R Sheybanikashani S Mohebi M. Exploring the role of molecular dynamics simulations in recent cancer research: insights into treatment strategies. 2023."},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S53892"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.715877"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13151244"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.07.041"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-386933-3.00008-4"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.956277"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/db21-1204"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10798"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2016.05.003"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.add6220"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-10-5721-7_8"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2015-103072"},{"key":"e_1_3_4_28_1","unstructured":"German Diabetes Center. Expression of G-protein coupled receptor 120 receptor in adipose tissue of German diabetes center cohort subjects. 2023 [cited 2025 May 7]. Available from: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT05368402"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2016.01.021"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867330666221123114312"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11094-024-02828-6"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114154"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-020-0428-6"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c02214"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2011.05.004"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2013.842977"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111613"},{"key":"e_1_3_4_38_1","unstructured":"Sui Z Cai C Zhang X. GPR120 agonists for the treatment of type II diabetes. US patent US20180119764A1. 2018."},{"key":"e_1_3_4_39_1","unstructured":"Illig CR Player MR Zhang X. Isothiazole derivatives as GPR120 agonists for the treatment of type II diabetes. US patent US20150306007A1. 2015."},{"key":"e_1_3_4_40_1","unstructured":"Sui Z Winters MP. Bicyclic pyrrole derivatives useful as agonists of GPR120. US patent US20140045804A1. 2014."},{"key":"e_1_3_4_41_1","unstructured":"Lanter JC Morin J Ammerman M et al. Cycloalkenyl derivatives useful as agonists of the GPR120 and\/or GPR40 receptors. US patent US20220203667A1. 2022."},{"key":"e_1_3_4_42_1","unstructured":"Lanter JC Wall M Sui Z. Heterocycloalkenyl derivatives useful as agonists of the GPR120 and\/or GPR40. US patent US20210119910A1. 2021."},{"key":"e_1_3_4_43_1","unstructured":"Sui Z Subasinghe N. Benzo-fused heterocyclic derivatives useful as agonists of GPR120. US patent US20170175044A1. 2017."},{"key":"e_1_3_4_44_1","unstructured":"Chelliah M Subasinghe N Patel M et al. Substituted spiropiperidinyl compounds useful as GPR120 agonists. US patent US20170319832A1. 2017."},{"key":"e_1_3_4_45_1","unstructured":"Suzuki N Li G Anderson M et al. Substituted tetrahydroisoquinoline compounds useful as GPR120 agonists. Merck Sharp & Dohme LLC. US patent US20200185384A1. 2020."},{"key":"e_1_3_4_46_1","unstructured":"Debenham JS McAtee JJ Pattaropong V et al. Hydroxy isoxazole compounds useful as GPR120 agonists. US patent US20200290140A1. 2020."},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2020.1811852"},{"key":"e_1_3_4_48_1","unstructured":"Kumar S Chelliah M Subasinghe N et al. Phenyl alkanoic acid derivatives as GPR agonists. US patent US20130324584A1. 2013."},{"key":"e_1_3_4_49_1","unstructured":"Raimundo B Desai A DaRe J et al. Bicyclic compounds useful as GPR120 modulators. US patent US20200110513A1. 2020."},{"key":"e_1_3_4_50_1","unstructured":"A Co. Preparation of monoterpene and olefin derivatives as novel GPR120 agonists as food additives. Patent application. 2019."},{"key":"e_1_3_4_51_1","unstructured":"Rost M. Domp\u00e9 Farmaceutici Spa. Patent filing. 2018."},{"key":"e_1_3_4_52_1","unstructured":"Janssen Pharmaceutica NV B.B. GPR120 agonists for the treatment of type II diabetes. Patent application. 2020."},{"key":"e_1_3_4_53_1","unstructured":"Piramal Enterprises Ltd. Compounds containing carbon\u2013carbon linker as GPR120 agonists. Patent application. 2021."},{"key":"e_1_3_4_54_1","unstructured":"The Trustees of Dartmouth College. Fatty acid mimetics as modulators of GPR40 and\/or GPR120. Patent application. 2024."},{"key":"e_1_3_4_55_1","unstructured":"Valo Health Inc. Bicyclic compounds useful as GPR120 modulators. Patent application. 2024."},{"key":"e_1_3_4_56_1","unstructured":"Valo Health Inc. Monocyclic compounds useful as GPR120 modulators. Patent application. 2024."},{"key":"e_1_3_4_57_1","unstructured":"Soochow University. A GPR120 agonist and its preparation method and application. Patent application. 2023."},{"key":"e_1_3_4_58_1","unstructured":"Chengdu Taier Pharmaceutical Technology Ltd. Tetrahydro-benzazepine derivatives as GPR120 modulators. Patent application. 2023."},{"key":"e_1_3_4_59_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1RA09117A"},{"key":"e_1_3_4_60_1","unstructured":"Chinese Academy of Sciences Dalian Institute of Chemical Physics. GPR120 agonists and application of ursodeoxycholic acid. Patent application. 2022."},{"key":"e_1_3_4_61_1","unstructured":"Nanchang University of Traditional Chinese Medicine. Adipocytes with high FFAR4 expression and their use. Patent application. 2023."},{"key":"e_1_3_4_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27249018"},{"key":"e_1_3_4_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115748"},{"key":"e_1_3_4_64_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S372766"},{"key":"e_1_3_4_65_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0FO02392J"},{"key":"e_1_3_4_66_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.15.149"},{"key":"e_1_3_4_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2010.116"},{"key":"e_1_3_4_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471141755.ph0214s70"},{"key":"e_1_3_4_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-800-9_5"},{"key":"e_1_3_4_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xinn.2024.100485"},{"key":"e_1_3_4_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.121475"},{"key":"e_1_3_4_72_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2017.7424"},{"key":"e_1_3_4_73_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753425913501098"},{"key":"e_1_3_4_74_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000038602.13208.5A"},{"key":"e_1_3_4_75_1","doi-asserted-by":"publisher","DOI":"10.4161\/psb.4.10.9641"},{"key":"e_1_3_4_76_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.110.065052"},{"key":"e_1_3_4_77_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom15020265"},{"key":"e_1_3_4_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2017.06.003"},{"key":"e_1_3_4_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2010.11.003"},{"key":"e_1_3_4_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2011.05.002"},{"key":"e_1_3_4_81_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu9091042"},{"key":"e_1_3_4_82_1","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S51119"},{"key":"e_1_3_4_83_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000251742.71301.16"},{"key":"e_1_3_4_84_1","volume-title":"A foray into the worlds of animals and humans: with a theory of meaning","author":"Von Uexk\u00fcll J","year":"2013","unstructured":"Von Uexk\u00fcll J. A foray into the worlds of animals and humans: with a theory of meaning. Minneapolis: University of Minnesota Press; 2013."},{"key":"e_1_3_4_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2013.10.008"},{"key":"e_1_3_4_86_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26227011"},{"key":"e_1_3_4_87_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43556-023-00147-w"}],"container-title":["Expert Opinion on Therapeutic Patents"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13543776.2025.2547036","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T11:14:06Z","timestamp":1756725246000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/13543776.2025.2547036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,17]]},"references-count":86,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9,2]]}},"alternative-id":["10.1080\/13543776.2025.2547036"],"URL":"https:\/\/doi.org\/10.1080\/13543776.2025.2547036","relation":{},"ISSN":["1354-3776","1744-7674"],"issn-type":[{"value":"1354-3776","type":"print"},{"value":"1744-7674","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,17]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ietp20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ietp20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2025-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}