{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T05:24:53Z","timestamp":1774502693347,"version":"3.50.1"},"reference-count":176,"publisher":"Informa UK Limited","issue":"11","funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI11\/01030"],"award-info":[{"award-number":["PI11\/01030"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007406","name":"BBVA Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007406","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Investigational Drugs"],"published-print":{"date-parts":[[2016,11,1]]},"DOI":"10.1080\/13543784.2016.1241764","type":"journal-article","created":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T11:48:33Z","timestamp":1475581713000},"page":"1295-1309","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":25,"title":["Investigational calcium channel blockers for the treatment of hypertension"],"prefix":"10.1080","volume":"25","author":[{"given":"J","family":"Tamargo","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Instituto de Investigaci\u00f3n Sanitaria Gregorio Mara\u00f1\u00f3n, Universidad Complutense, Madrid, Spain. CIBER of Cardiovascular Diseases"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Miguel","family":"Ruilope","sequence":"additional","affiliation":[{"name":"Hypertension Unit, Hospital 12 de Octubre, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2016,10,20]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.11.028"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.51.030189.001531"},{"key":"CIT0003","doi-asserted-by":"crossref","unstructured":"Low AM, Kotecha N, Neild TO, et al. Relative contributions of extracellular Ca2+and Ca2+stores to smooth muscle contraction in arteries and arterioles of rat, guinea-pig, dog and rabbit. Clin Exp Pharmacol Physiol 1996;23:310-316. Available from: \u201chttps:\/\/www.ncbi.nlm.nih.gov\/pubmed\/8717067\u201c 8717067. DOI: 10.1111\/j.1440-1681.1996.tb02829.x","DOI":"10.1111\/j.1440-1681.1996.tb02829.x"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1124\/pr.114.009654"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1124\/pr.57.4.5"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a003947"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.4161\/chan.4.6.12870"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00018.2002"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg583"},{"key":"CIT0010","doi-asserted-by":"crossref","first-page":"e97","DOI":"10.1161\/01.RES.0000131495.93500.3c","volume":"94","author":"Pesic A","year":"2004","journal-title":"Circ Res"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000025877.23309.36"},{"issue":"341","key":"CIT0012","first-page":"1447","volume":"199","author":"Abernethy DR","journal-title":"N Engl J Med"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2007.01.016"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2006.04.025"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.145672"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-013-1430-x"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvs257"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.184051"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000106134.69300.B7"},{"key":"CIT0020","doi-asserted-by":"crossref","first-page":"F674","DOI":"10.1152\/ajprenal.1999.276.5.F674","volume":"276","author":"Chen XL","year":"1999","journal-title":"Am J Physiol Ren Physiol"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701861"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.29.493"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000256155.31133.49"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002773"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12070"},{"key":"CIT0026","doi-asserted-by":"crossref","first-page":"R227","DOI":"10.1152\/ajpregu.00276.2014","volume":"308","author":"Hansen PBL","year":"2015","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(01)76100-0"},{"key":"CIT0028","first-page":"H582","volume":"280","author":"Gustafsson F","year":"2001","journal-title":"Am J Physiol"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.125831"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1159\/000151767"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.126128"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199508000-00018"},{"key":"CIT0033","doi-asserted-by":"crossref","first-page":"H2239","DOI":"10.1152\/ajpheart.00531.2002","volume":"283","author":"VanBavel E","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704892"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.03.055"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.28.889"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e3181624b05"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2011.02.030"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.2174\/157340210903140415124048"},{"key":"CIT0040","doi-asserted-by":"crossref","unstructured":"Koh K, Quon M, Lee S, et al. Efonidipine simultaneously improves blood pressure, endothelial function, and metabolic parameters in nondiabetic patients with hypertension. Diabetes Care 2007;30:1605-7. PMID: 17351278. DOI: \u201chttps:\/\/dx.doi.org\/10.2337\/dc06-2267\u201d 10.2337\/dc06-2267.","DOI":"10.2337\/dc06-2267"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.5551\/jat.1628"},{"key":"CIT0042","doi-asserted-by":"crossref","unstructured":"Howitt L, Chaston DJ, Sandow SL, et al. Spreading vasodilatation in the murine microcirculation: attenuation by oxidative stress-induced change in electromechanical coupling. J Physiol 2013;591: 2157-73. Available from: \u201chttps:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23440962\u201d 23440962; \u201chttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3634526\/\u201d PMC3634526; DOI: \u201chttps:\/\/dx.doi.org\/10.1113\/jphysiol.2013.250928\u201d 10.1113\/jphysiol.2013.250928","DOI":"10.1113\/jphysiol.2013.250928"},{"key":"CIT0043","doi-asserted-by":"crossref","unstructured":"Abd El-Rahman RR, Harraz OF, Brett SE, et al. Identification of L- and T-type Ca2+channels in rat cerebral arteries: role in myogenic tone development. Am J Physiol Heart Circ Physiol 2013;304:H58 -H71. Available from: \u201chttps:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23103495\u201c 23103495; \u201chttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3543679\/\u201cPMC3543679; DOI: \u201chttps:\/\/dx.doi.org\/10.1152\/ajpheart.00476.2012\u201c 10.1152\/ajpheart.00476.2012.","DOI":"10.1152\/ajpheart.00476.2012"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.114.304056"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.4161\/chan.4.6.12869"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.14.2.177"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.3109\/07853890008995939"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000431740.32696.cc"},{"key":"CIT0049","doi-asserted-by":"crossref","unstructured":"Jensen LJ, Salomonsson M, Jensen BL, et al. Depolarization- induced calcium influx in rat mesenteric small arterioles is mediated exclusively via mibefradil-sensitive calcium channels. Br J Pharmacol 2004;142:709-18. Available from: \u201chttps:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15172957\u201d 15172957; PMCID: \u201chttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1575051\/\u201d PMC1575051; DOI: \u201chttps:\/\/dx.doi.org\/10.1038\/sj.bjp.0705841\u201d 10.1038\/sj.bjp.0705841","DOI":"10.1038\/sj.bjp.0705841"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199503000-00017"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(99)00237-X"},{"key":"CIT0052","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/S0022-3565(24)35127-4","volume":"291","author":"Furukawa T","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.2174\/0929867321666141106113018"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.81.4.526"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1989.69.2.546"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.80.2.285"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1007\/BF00051613"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000013264.41234.24"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(97)80034-3"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2002.122869"},{"key":"CIT0061","doi-asserted-by":"crossref","unstructured":"Moosmang S, Haider N, Br\u00fcderl B, et al. Antihypertensive effects of the putative T-type calcium channel antagonist mibefradil are mediated by the L-type calcium channel Cav1.2. Circ Res 2006;98:105-10. Available from: \u201chttps:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16306443\u201d 16306443. DOI: \u201chttps:\/\/dx.doi.org\/10.1161\/01.RES.0000197851.11031.9c\u201d 10.1161\/01.RES.0000197851.11031.9c","DOI":"10.1161\/01.RES.0000197851.11031.9c"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.30.797"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.2165\/11320000-000000000-00000"},{"key":"CIT0064","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1097\/HJH.0b013e3283388045","volume":"28","author":"Yamamoto E","year":"2010","journal-title":"J Hypertens"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.133892"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1007\/BF00374478"},{"key":"CIT0067","doi-asserted-by":"crossref","unstructured":"Furukawa T, Miura R, Honda M, et al. Identification of R(-)-isomer of efonidipine as a selective blocker of T-type Ca2+channels. Br. J. Pharmacol 2004;143:1050-7. Available from: \u201chttps:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15545287\u201c 15545287; \u201chttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC1575949\/\u201c PMC1575949; DOI: \u201chttps:\/\/dx.doi.org\/10.1038\/sj.bjp.0705944\u201c 10.1038\/sj.bjp.0705944","DOI":"10.1038\/sj.bjp.0705944"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.RCJ04001X"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2011.03.019"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2010.483"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00033.x"},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000139860.33974.28"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.09910.x"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.1999.03114.x"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.170845"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1159\/000167536"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200111000-00014"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.1159\/000368539"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.25.571"},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.38.3.343"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002793"},{"key":"CIT0082","doi-asserted-by":"crossref","unstructured":"Nakamura Y, Ono H, Frohlich ED. Differential effects of T- and L-type calcium antagonists on glomerular dynamics in spontaneously hypertensive rats. Hypertension 1999;34:273\u20138. Available from: \u201chttps:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10454453\u201d 10454453","DOI":"10.1161\/01.HYP.34.2.273"},{"key":"CIT0083","doi-asserted-by":"crossref","unstructured":"Li X, Yang MS. Effects of T-type calcium channel blockers on renal function and aldosterone in patients with hypertension: a systematic review and meta-analysis. PloS One 2014;9:e109834. Available from: \u201chttps:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25330103\u201d 25330103. \u201chttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4201480\/\u201d PMC4201480. DOI: \u201chttps:\/\/dx.doi.org\/10.1371\/journal.pone.0109834\u201d 10.1371\/journal.pone.0109834","DOI":"10.1371\/journal.pone.0109834"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.03.025"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.69.127"},{"key":"CIT0086","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/S0022-3565(24)36515-2","volume":"280","author":"Fujii S","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2015.69"},{"key":"CIT0088","doi-asserted-by":"crossref","unstructured":"Wellington K, Scott LJ. \u201chttp:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14636080\u201d Azelnidipine. Drugs 2003;63:2613-21. Available from: \u201chttps:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14636080\u201d 14636080","DOI":"10.2165\/00003495-200363230-00004"},{"key":"CIT0089","first-page":"1","volume":"54","author":"Koike H","year":"2002","journal-title":"Annu Rep Sankyo Res Lab"},{"key":"CIT0090","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.28.1017"},{"key":"CIT0091","doi-asserted-by":"crossref","unstructured":"Konno S, Hirooka Y, Araki S, et al. Azelnidipine decreases sympathetic nerve activity via antioxidant effect in the rostral ventrolateral medulla of stroke-prone spontaneously hypertensive rats. J Cardiovasc Pharmacol 2008;52:555-60. Available from: \u201chttps:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19057394\u201d 19057394. dOI: \u201chttps:\/\/dx.doi.org\/10.1097\/FJC.0b013e318192690e\u201d 10.1097\/FJC.0b013e318192690e","DOI":"10.1097\/FJC.0b013e318192690e"},{"key":"CIT0092","doi-asserted-by":"publisher","DOI":"10.1080\/10641960601096745"},{"key":"CIT0093","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2840-9-82"},{"key":"CIT0094","doi-asserted-by":"publisher","DOI":"10.1177\/147323000403200210"},{"key":"CIT0095","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.29.767"},{"key":"CIT0096","first-page":"215","volume":"31","author":"Matsui T","year":"2005","journal-title":"Drugs Exp Clin Res"},{"key":"CIT0097","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-007-6008-4"},{"key":"CIT0098","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2007.03.036"},{"key":"CIT0099","first-page":"309","volume":"11","author":"Chen BL","year":"2015","journal-title":"Ther Clin Risk Manag"},{"key":"CIT0100","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.26.201"},{"key":"CIT0101","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e318065c254"},{"key":"CIT0102","doi-asserted-by":"publisher","DOI":"10.1002\/clc.20885"},{"key":"CIT0103","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e31804d1cf1"},{"key":"CIT0104","first-page":"269","volume":"16","author":"Kobayashi K","year":"2000","journal-title":"J Clin Ther Med"},{"key":"CIT0105","first-page":"671","volume":"16","author":"Yoshinaga K","year":"2000","journal-title":"J Clin Ther Med"},{"key":"CIT0106","doi-asserted-by":"publisher","DOI":"10.1159\/000338132"},{"key":"CIT0107","doi-asserted-by":"publisher","DOI":"10.1007\/s40268-013-0006-8"},{"key":"CIT0108","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.12.010"},{"key":"CIT0109","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2012.326"},{"key":"CIT0110","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2014.164"},{"key":"CIT0111","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-015-0073-9"},{"key":"CIT0112","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.DTJ05001X"},{"key":"CIT0113","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.17.1468"},{"key":"CIT0114","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200103000-00013"},{"key":"CIT0115","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.84.56"},{"key":"CIT0116","doi-asserted-by":"crossref","unstructured":"Karasawa A, Kubo K. Protection by benidipine hydrochloride (KW-3049), a calcium antagonist, of ischemic kidney in rats via inhibitions of Ca-overload, ATP-decline and lipid peroxidation. Jpn J Pharmacol 1990;52:553\u201362. Available from: \u201chttps:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2342226\u201d 2342226","DOI":"10.1254\/jjp.52.553"},{"key":"CIT0117","first-page":"314","volume":"53","author":"Nomura M","year":"2003","journal-title":"Arzneim-Forsch\/Drug Res"},{"key":"CIT0118","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-08-0188"},{"key":"CIT0119","doi-asserted-by":"publisher","DOI":"10.1080\/08038020510040612"},{"key":"CIT0120","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.28.959"},{"key":"CIT0121","first-page":"526","volume":"57","author":"Seino H","year":"2007","journal-title":"Arzneimittelforschung"},{"key":"CIT0122","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328348345d"},{"key":"CIT0123","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2011.216"},{"key":"CIT0124","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2013.100"},{"key":"CIT0125","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2015.104"},{"key":"CIT0126","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2009.11"},{"key":"CIT0127","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2010.221"},{"key":"CIT0128","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2004.00272.x"},{"key":"CIT0129","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2369-14-135"},{"key":"CIT0130","doi-asserted-by":"crossref","first-page":"c49","DOI":"10.1159\/000078400","volume":"97","author":"Kojima M","year":"2004","journal-title":"Nephron Clin Pract"},{"key":"CIT0131","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5922.2009.00079.x"},{"key":"CIT0132","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.28.1003"},{"key":"CIT0133","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12042"},{"key":"CIT0134","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199808000-00023"},{"key":"CIT0135","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2000.00299.x"},{"key":"CIT0136","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200401000-00011"},{"key":"CIT0137","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-004-0817-1"},{"key":"CIT0138","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2010.01.048"},{"key":"CIT0139","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2010.191"},{"key":"CIT0140","first-page":"163","volume":"27","author":"Fujii S","year":"1999","journal-title":"JPN Pharmacol Ther"},{"key":"CIT0141","doi-asserted-by":"publisher","DOI":"10.1159\/000085713"},{"key":"CIT0142","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.29.933"},{"key":"CIT0143","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200205000-00035"},{"key":"CIT0144","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.24.565"},{"key":"CIT0145","first-page":"799","volume":"8","author":"Mori Y","year":"2014","journal-title":"Drug Des Devel Ther"},{"key":"CIT0146","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.33.6.1447"},{"key":"CIT0147","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.30.815"},{"key":"CIT0148","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(01)02159-8"},{"key":"CIT0149","doi-asserted-by":"crossref","unstructured":"Principal results of the Japanese trial to assess optimal systolic blood pressure in elderly hypertensive patients (JATOS). JATOS Study Group. Hypertens Res 2008;31:2115-27. Available from: \u201chttps:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19139601\u201d 19139601. DOI: \u201chttps:\/\/dx.doi.org\/10.1291\/hypres.31.2115\u201d 10.1291\/hypres.31.2115","DOI":"10.1291\/hypres.31.2115"},{"key":"CIT0150","first-page":"S155","volume":"21","author":"Iimura O","year":"1993","journal-title":"JPN Pharmacol Ther"},{"key":"CIT0151","doi-asserted-by":"crossref","unstructured":"Rose GW, Kanno Y, Ikebukuro H, et al. Cilnidipine is as effective as benazepril for control of blood pressure and proteinuria in hypertensive patients with benign nephrosclerosis. Hypertens Res 2001;24:377-83. Available from: \u201chttps:\/\/www.ncbi.nlm.nih.gov\/pubmed\/11510750\u201d 11510750","DOI":"10.1291\/hypres.24.377"},{"key":"CIT0152","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e3282c2fa62"},{"key":"CIT0153","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.48.597"},{"key":"CIT0154","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.29.339"},{"key":"CIT0155","first-page":"618","volume":"20","author":"Tan H-W","year":"2006","journal-title":"J Hum"},{"key":"CIT0156","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e31802bfdee"},{"key":"CIT0157","first-page":"117","volume":"29","author":"Sakata K","year":"2003","journal-title":"Drugs Exp Clin Res"},{"key":"CIT0158","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12113"},{"key":"CIT0159","doi-asserted-by":"publisher","DOI":"10.4103\/1947-2714.106203"},{"key":"CIT0160","doi-asserted-by":"publisher","DOI":"10.1080\/10641960500298558"},{"key":"CIT0161","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.27.379"},{"key":"CIT0162","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000349"},{"key":"CIT0163","doi-asserted-by":"publisher","DOI":"10.3390\/ijms140816866"},{"key":"CIT0164","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002623"},{"key":"CIT0165","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.5508"},{"key":"CIT0166","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2006.06.001"},{"key":"CIT0167","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200969010-00002"},{"key":"CIT0168","doi-asserted-by":"publisher","DOI":"10.1016\/0306-3623(94)90356-5"},{"key":"CIT0169","first-page":"852","volume":"46","author":"Shudo C","year":"1996","journal-title":"Arzneimittel Forschung"},{"key":"CIT0170","doi-asserted-by":"publisher","DOI":"10.3109\/10641969809052123"},{"key":"CIT0171","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2010.162"},{"key":"CIT0172","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.30.691"},{"key":"CIT0173","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2009.78"},{"key":"CIT0174","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.31.2115"},{"key":"CIT0175","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(02)03147-3"},{"key":"CIT0176","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.30.621"}],"container-title":["Expert Opinion on Investigational Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13543784.2016.1241764","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T22:36:13Z","timestamp":1749594973000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/13543784.2016.1241764"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,20]]},"references-count":176,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11,1]]}},"alternative-id":["10.1080\/13543784.2016.1241764"],"URL":"https:\/\/doi.org\/10.1080\/13543784.2016.1241764","relation":{},"ISSN":["1354-3784","1744-7658"],"issn-type":[{"value":"1354-3784","type":"print"},{"value":"1744-7658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,20]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieid20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieid20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2016-05-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}