{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:51:28Z","timestamp":1787007088700,"version":"build-2736575974"},"reference-count":132,"publisher":"Informa UK Limited","issue":"1","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Investigational Drugs"],"published-print":{"date-parts":[[2018,1,2]]},"DOI":"10.1080\/13543784.2018.1416090","type":"journal-article","created":{"date-parts":[[2017,12,9]],"date-time":"2017-12-09T08:13:44Z","timestamp":1512807224000},"page":"71-86","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":8,"title":["New anticoagulants for venous thromboembolism and atrial fibrillation: what the future holds"],"prefix":"10.1080","volume":"27","author":[{"given":"Gerasimos","family":"Dimitropoulos","sequence":"first","affiliation":[{"name":"Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK"},{"name":"Cardiology Department, City Hospital, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. M. Zubair","family":"Rahim","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK"},{"name":"Cardiology Department, City Hospital, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra Sophie","family":"Moss","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK"},{"name":"Cardiology Department, City Hospital, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory Y. H.","family":"Lip","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Sciences, University of Birmingham, Birmingham, UK"},{"name":"Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2017,12,14]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.19.1.97"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000063575.17904.4E"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.685974"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1160\/TH16-06-0485"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1160\/TH16-06-0488"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1160\/TH15-03-0247"},{"key":"CIT0008","volume-title":"Haematology","author":"Pallister CJ","year":"2010","edition":"2"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62343-0"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12485"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2013.03.006"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2017.02.002"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2294"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01251.x"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830470303"},{"key":"CIT0016","author":"Harker L","year":"2000","journal-title":"Circulation"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31828e9b03"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.02267.x"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.01900.x"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.03271.x"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2010.06.012"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04221.x"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(93)22011-4"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14021-4"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(98)70419-2"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1161\/hs0202.102950"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1161\/hq0302.105375"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1038\/nature00963"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.668434"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02872.x"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2003.00428.x"},{"key":"CIT0032","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1182\/blood.V106.11.1886.1886","volume":"106","author":"Rothlein R","year":"2015","journal-title":"Blood"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.203117"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezv159"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.02932.x"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs232"},{"key":"CIT0037","doi-asserted-by":"crossref","first-page":"A9771","DOI":"10.1161\/circ.124.suppl_21.A9771","volume":"124","author":"Ahrens I","year":"2011","journal-title":"Circulation"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.04.058"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00515-2"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2003.00298.x"},{"key":"CIT0041","first-page":"182","volume":"11","author":"Turpie AG","year":"2002","journal-title":"J South Orthop Assoc"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.8.2308"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.853119"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht039"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2013.825605"},{"key":"CIT0046","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1182\/blood.V108.11.901.901","volume":"108","author":"Abe K","year":"2006","journal-title":"Blood"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2013.11.006"},{"key":"CIT0048","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1160\/TH08-07-0460","volume":"101","author":"Turpie AG","year":"2009","journal-title":"Thromb Haemost"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1601747"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.025427"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1002\/bdd.1858"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr334"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.3109\/00498254.2012.738045"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.10.009"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2012.11.026"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1177\/1076029612457810"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1160\/TH13-04-0296"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2012.06.009"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13025"},{"key":"CIT0062","first-page":"305","volume":"70","author":"Stringer F","year":"2010","journal-title":"Br J Clin Pharmacol"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.2165\/0003088-200948010-00001"},{"key":"CIT0064","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2007-12-125856","volume":"112","author":"Kawamura M","year":"2008","journal-title":"Blood"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e3181e2bfcf"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1160\/TH10-05-0273"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1160\/TH13-07-0543"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02436.x"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1002\/psp4.12103"},{"key":"CIT0070","first-page":"93","volume":"2","author":"Roffel A","year":"2017","journal-title":"Int J"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12328"},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1002\/cpdd.232"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0285.2007.00539.x"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.158691"},{"key":"CIT0075","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1160\/TH07-09-0576","volume":"99","author":"Karnicki K","year":"2008","journal-title":"Thromb Haemost"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1160\/TH10-05-0307"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-120139"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003093421004"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-05-219915"},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03393.x"},{"key":"CIT0081","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1538-7836.2009.03395.x","volume":"7","author":"Factor SU","year":"2009","journal-title":"J Thromb Haemost"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(16)30363-2"},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-277798"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.606442"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-12-540872"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.113.301282"},{"key":"CIT0087","volume":"118","author":"Liu Q","year":"2011","journal-title":"Blood"},{"key":"CIT0088","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1405760"},{"key":"CIT0089","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-02-270918"},{"key":"CIT0090","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-06-163675"},{"key":"CIT0091","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-011-0599-0"},{"key":"CIT0092","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1055\/s-0037-1614368","volume":"82","author":"Zeerleder S","year":"1999","journal-title":"Thromb Haemost"},{"key":"CIT0093","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-04-499111"},{"key":"CIT0094","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006804"},{"key":"CIT0095","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12302"},{"key":"CIT0096","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.6.544"},{"key":"CIT0097","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0905561"},{"key":"CIT0098","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1160\/TH08-09-0586","volume":"101","author":"Deinum J","year":"2009","journal-title":"Thromb Haemost"},{"key":"CIT0099","first-page":"130","volume":"101","author":"Cullberg M","year":"2007","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"CIT0100","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp318"},{"key":"CIT0101","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-10-0744"},{"key":"CIT0102","doi-asserted-by":"publisher","DOI":"10.2165\/11536300-000000000-00000"},{"key":"CIT0103","doi-asserted-by":"publisher","DOI":"10.5414\/CP201465"},{"key":"CIT0104","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-07-0509"},{"key":"CIT0105","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12719"},{"key":"CIT0106","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-010-0849-7"},{"key":"CIT0107","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.856120"},{"key":"CIT0108","doi-asserted-by":"publisher","DOI":"10.1177\/0091270010370588"},{"key":"CIT0109","doi-asserted-by":"publisher","DOI":"10.1160\/TH16-08-0623"},{"key":"CIT0110","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00420.x"},{"key":"CIT0111","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2010.08.025"},{"key":"CIT0112","doi-asserted-by":"publisher","DOI":"10.1160\/TH15-11-0910"},{"key":"CIT0114","doi-asserted-by":"publisher","DOI":"10.1160\/TH16-05-0363"},{"key":"CIT0115","first-page":"35","volume":"12","author":"Hu TY","year":"2016","journal-title":"Vasc Health Risk Manag"},{"key":"CIT0116","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-11-468207"},{"key":"CIT0117","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1182\/blood.V124.21.2878.2878","volume":"124","author":"Arellano-Rodrigo E","year":"2014","journal-title":"Blood"},{"key":"CIT0118","doi-asserted-by":"publisher","DOI":"10.1186\/cc13717"},{"key":"CIT0119","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.07.051"},{"key":"CIT0120","doi-asserted-by":"publisher","DOI":"10.1160\/TH14-12-1080"},{"key":"CIT0121","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60732-2"},{"key":"CIT0123","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-02-514778"},{"key":"CIT0124","doi-asserted-by":"publisher","DOI":"10.1160\/TH15-03-0192"},{"key":"CIT0125","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1502000"},{"key":"CIT0126","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1707278"},{"key":"CIT0127","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3102"},{"key":"CIT0128","doi-asserted-by":"crossref","first-page":"A10","DOI":"10.1161\/atvb.33.suppl_1.A10","volume":"33","author":"Crowther M","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"CIT0129","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1510991"},{"key":"CIT0130","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1607887"},{"key":"CIT0131","doi-asserted-by":"publisher","DOI":"10.1358\/dof.2016.041.06.2490311"},{"key":"CIT0132","first-page":"A11395","volume":"126","author":"Laulicht B","year":"2012","journal-title":"Circulation"},{"key":"CIT0133","doi-asserted-by":"publisher","DOI":"10.1160\/TH16-03-0224"},{"key":"CIT0134","first-page":"859","volume":"36","author":"Laulicht B","year":"2015","journal-title":"Eur Heart J"},{"key":"CIT0135","doi-asserted-by":"publisher","DOI":"10.1160\/TH16-11-0876"},{"key":"CIT0136","doi-asserted-by":"publisher","DOI":"10.1160\/TH16-08-0658"},{"key":"CIT0137","doi-asserted-by":"publisher","DOI":"10.1160\/TH16-03-0203"}],"container-title":["Expert Opinion on Investigational Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13543784.2018.1416090","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T11:46:41Z","timestamp":1719661601000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/13543784.2018.1416090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,14]]},"references-count":132,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,12,25]]},"published-print":{"date-parts":[[2018,1,2]]}},"alternative-id":["10.1080\/13543784.2018.1416090"],"URL":"https:\/\/doi.org\/10.1080\/13543784.2018.1416090","relation":{},"ISSN":["1354-3784","1744-7658"],"issn-type":[{"value":"1354-3784","type":"print"},{"value":"1744-7658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,14]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieid20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieid20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"}]}}