{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T09:18:29Z","timestamp":1772788709543,"version":"3.50.1"},"reference-count":65,"publisher":"Informa UK Limited","issue":"8","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Investigational Drugs"],"published-print":{"date-parts":[[2019,8,3]]},"DOI":"10.1080\/13543784.2019.1646727","type":"journal-article","created":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T06:05:06Z","timestamp":1564121106000},"page":"733-740","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":23,"title":["Investigational drugs for the treatment of cancer cachexia: a focus on phase I and phase II clinical trials"],"prefix":"10.1080","volume":"28","author":[{"given":"Alessio","family":"Molfino","sequence":"first","affiliation":[{"name":"Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Ida","family":"Amabile","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Sapienza University of Rome, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Giorgi","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Monti","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Sapienza University of Rome, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vito","family":"D\u2019Andrea","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Sapienza University of Rome, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Muscaritoli","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2019,7,26]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2016.1208168"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2009.12.004"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2014.10.014"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1097\/SPC.0000000000000383"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.06.060"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2008.06.005"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70218-7"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.105"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1177\/1758834017698643"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw420"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.2217\/fon.15.195"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.06.011"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1097\/SPC.0000000000000299"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-009-0547-z"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19113471"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.2217\/fon.14.14"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2015.1041500"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.2174\/138161212803216906"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.12-5-594"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)71154-4"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00558-6"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx192"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2014.942729"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.11.7983"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1038\/ncpendmet0120"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12295"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1210\/me.2008-0160"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-016-0522-0"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.2217\/fon.13.273"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2010.02.012"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2012.0146"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2354.2011.01255.x"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01457.x"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2010.28.15_suppl.7622"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2009.06.020"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70155-X"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-015-0226-6"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30006-2"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.7150\/jca.28246"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq727"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-018-4154-9"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1177\/0003489415612801"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.3109\/07357907.2011.626476"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.07.015"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.06.156"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5987082"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000032"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.005611"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e32835d2d99"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-14-382"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20362"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2014.03.006"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0538"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1177\/1534735416651968"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12126"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-013-2081-3"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.02.033"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000045"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1007\/s13539-012-0067-5"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12201"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1136\/bmjspcare-2017-001440"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-010-0426-1"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201847258"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2011.10.005"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2011.12.435"}],"container-title":["Expert Opinion on Investigational Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13543784.2019.1646727","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T09:19:17Z","timestamp":1582190357000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/13543784.2019.1646727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,26]]},"references-count":65,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8,3]]}},"alternative-id":["10.1080\/13543784.2019.1646727"],"URL":"https:\/\/doi.org\/10.1080\/13543784.2019.1646727","relation":{},"ISSN":["1354-3784","1744-7658"],"issn-type":[{"value":"1354-3784","type":"print"},{"value":"1744-7658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,26]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieid20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieid20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2019-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}