{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T18:33:13Z","timestamp":1776709993072,"version":"3.51.2"},"reference-count":48,"publisher":"Informa UK Limited","issue":"12","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Investigational Drugs"],"published-print":{"date-parts":[[2019,12,2]]},"DOI":"10.1080\/13543784.2019.1676725","type":"journal-article","created":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T12:48:26Z","timestamp":1570798106000},"page":"1051-1057","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":34,"title":["Siponimod in the treatment of multiple sclerosis"],"prefix":"10.1080","volume":"28","author":[{"given":"Andrew D","family":"Goodman","sequence":"first","affiliation":[{"name":"Neuroimmunology Division, Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nidhiben","family":"Anadani","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Oklahoma Medical Center, Oklahoma City, OK, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee","family":"Gerwitz","sequence":"additional","affiliation":[{"name":"Neuroimmunology Division, Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2019,11,3]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000560"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1579739"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1179\/016164106X98099"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1601277"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.168"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.222"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606468"},{"issue":"5","key":"CIT0008","first-page":"CD002127","volume":"31","author":"Martinelli Boneschi F","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17101-8"},{"issue":"1","key":"CIT0010","first-page":"CD005181","volume":"18","author":"La Mantia L","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30069-3"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.60.1.44"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21867"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21079"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01314-8"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.5.1145"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410370108"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-006-0459-6"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-015-0261-z"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909494"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1126\/science.1070238"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2014.06.028"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C200176200"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.02061.x"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2012.04400.x"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4645-04.2005"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-017-0565-4"},{"key":"CIT0029","first-page":"135245851878988","volume":"25","author":"Cohen JA","year":"2018","journal-title":"Mult Scler"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12129"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.117.079574"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-017-2404-2"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-018-0700-3"},{"issue":"3","key":"CIT0035","first-page":"391","volume":"76","author":"Lynch T","year":"2007","journal-title":"Am Fam Physician"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.5414\/CP202588"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.5414\/CP202608"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2013.02.011"},{"issue":"10","key":"CIT0039","volume":"82","author":"Tavares A","year":"2014","journal-title":"Neurology"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0686-4"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0494-x"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1636-12.2013"},{"issue":"16","key":"CIT0043","volume":"86","author":"Tiwari-Woodruff S","year":"2016","journal-title":"Neurology"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1038\/nature02284"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000327609.57688.ea"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70102-9"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0907839"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.1451"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30475-6"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000146958.77317.3E"}],"container-title":["Expert Opinion on Investigational Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13543784.2019.1676725","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T06:38:35Z","timestamp":1575441515000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/13543784.2019.1676725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,3]]},"references-count":48,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12,2]]}},"alternative-id":["10.1080\/13543784.2019.1676725"],"URL":"https:\/\/doi.org\/10.1080\/13543784.2019.1676725","relation":{},"ISSN":["1354-3784","1744-7658"],"issn-type":[{"value":"1354-3784","type":"print"},{"value":"1744-7658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,3]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieid20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieid20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2018-11-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}