{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T18:33:11Z","timestamp":1721068391602},"reference-count":154,"publisher":"Informa UK Limited","issue":"7","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Investigational Drugs"],"published-print":{"date-parts":[[2020,7,2]]},"DOI":"10.1080\/13543784.2020.1769066","type":"journal-article","created":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T19:37:29Z","timestamp":1589398649000},"page":"739-753","update-policy":"http:\/\/dx.doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":2,"title":["Metastatic melanoma: therapeutic agents in preclinical and early clinical development"],"prefix":"10.1080","volume":"29","author":[{"given":"Laura Amanda","family":"Boos","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, The Royal Marsden Hospital NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isla","family":"Leslie","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, The Royal Marsden Hospital NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Larkin","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, The Royal Marsden Hospital NHS Foundation Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2020,6,1]]},"reference":[{"key":"cit0001","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60802-8"},{"key":"cit0002","doi-asserted-by":"publisher","DOI":"10.1038\/nature00766"},{"key":"cit0003","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2016.01.025"},{"key":"cit0004","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103782"},{"key":"cit0005","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60868-X"},{"key":"cit0006","doi-asserted-by":"publisher","DOI":"10.1038\/nature14982"},{"key":"cit0007","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00087-X"},{"key":"cit0008","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30122-X"},{"key":"cit0009","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30142-6"},{"key":"cit0010","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30497-2"},{"key":"cit0011","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1904059"},{"key":"cit0012","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.467"},{"key":"cit0013","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0000000000000426"},{"key":"cit0014","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2015.03.004"},{"key":"cit0015","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3239"},{"key":"cit0016","doi-asserted-by":"publisher","DOI":"10.1038\/nature10673"},{"key":"cit0017","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90125-6"},{"key":"cit0018","doi-asserted-by":"publisher","DOI":"10.1126\/science.270.5238.985"},{"key":"cit0019","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00453"},{"key":"cit0020","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1003466"},{"key":"cit0021","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.56.2736"},{"key":"cit0022","doi-asserted-by":"publisher","DOI":"10.1038\/70932"},{"key":"cit0023","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.7.1027"},{"key":"cit0024","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80089-8"},{"key":"cit0025","doi-asserted-by":"publisher","DOI":"10.1126\/science.291.5502.319"},{"key":"cit0026","doi-asserted-by":"publisher","DOI":"10.1038\/nature04444"},{"key":"cit0027","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-019-1259-z"},{"key":"cit0028","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1910836"},{"key":"cit0029","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1104621"},{"key":"cit0030","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30231-0"},{"key":"cit0031","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1412082"},{"key":"cit0032","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.71.8023"},{"key":"cit0033","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2017.07.022"},{"key":"cit0034","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30388-2"},{"key":"cit0035","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30366-7"},{"key":"cit0036","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414428"},{"key":"cit0037","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.58.3377"},{"key":"cit0038","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-017-0276-8"},{"key":"cit0039","unstructured":"Assessment report Imlygic. European Medicines Agency. 2015 Oct. Available from: https:\/\/www.ema.europe.eu\/en\/documents\/assessment-report\/imlygic-epar-public"},{"key":"cit0040","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-019-0623-z"},{"key":"cit0041","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2012.08.016"},{"key":"cit0042","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510360033032"},{"key":"cit0043","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.7.2105"},{"key":"cit0044","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.22190"},{"key":"cit0045","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2016.06.07"},{"key":"cit0046","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-13-0617"},{"key":"cit0047","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2015.12.001"},{"key":"cit0048","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16558-0"},{"key":"cit0049","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-17-1119"},{"key":"cit0050","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-17-0456"},{"key":"cit0051","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2019.37.15_suppl.3001"},{"key":"cit0052","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1879"},{"key":"cit0053","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2014.912836"},{"key":"cit0054","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20174235"},{"key":"cit0055","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-1807"},{"key":"cit0056","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-0954-x"},{"key":"cit0057","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.04.012"},{"key":"cit0058","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-017-0667-y"},{"key":"cit0059","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.17950"},{"key":"cit0060","doi-asserted-by":"crossref","unstructured":"Entinostat helps Thwart immunotherapy resistance. Cancer Discov. 2019 Jun;9(6):685.2\u2013686.","DOI":"10.1158\/2159-8290.CD-NB2019-048"},{"key":"cit0061","unstructured":"AACR. Entinostat plus pembrolizumab in patients with melanoma previously treated with anti\u2013PD-1 therapy. The ASCO Post. 2019 Feb. [cited 2019 Dec 28]. Available from: https:\/\/www.ascopost.com\/News\/59894"},{"key":"cit0062","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602529"},{"key":"cit0063","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21834"},{"key":"cit0064","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.746"},{"key":"cit0065","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201344413"},{"key":"cit0066","doi-asserted-by":"publisher","DOI":"10.1159\/000500902"},{"key":"cit0067","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19051389"},{"key":"cit0068","doi-asserted-by":"publisher","DOI":"10.1084\/jem.171.5.1393"},{"key":"cit0069","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830241246"},{"key":"cit0070","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31184"},{"key":"cit0071","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2004.08.010"},{"key":"cit0072","doi-asserted-by":"publisher","DOI":"10.1038\/nri3790"},{"key":"cit0073","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100466"},{"key":"cit0074","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.35.15_suppl.9520"},{"key":"cit0075","doi-asserted-by":"publisher","DOI":"10.1038\/415536a"},{"key":"cit0076","doi-asserted-by":"publisher","DOI":"10.1038\/ni987"},{"key":"cit0077","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030676"},{"key":"cit0078","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-14-0039"},{"key":"cit0079","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2019.101302"},{"key":"cit0080","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100637"},{"key":"cit0081","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100643"},{"key":"cit0082","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-10-310425"},{"key":"cit0083","doi-asserted-by":"publisher","DOI":"10.1038\/85339"},{"key":"cit0084","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2017.90"},{"key":"cit0085","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-018-00719-7"},{"key":"cit0086","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1674"},{"key":"cit0087","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2014.10.018"},{"key":"cit0088","doi-asserted-by":"publisher","DOI":"10.1172\/JCI80445"},{"issue":"6","key":"cit0089","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1002\/cam4.2167","volume":"8","author":"St\u00e5lhammar G","year":"2019","journal-title":"Cancer Med"},{"key":"cit0090","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-016-1829-2"},{"key":"cit0091","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-0263"},{"key":"cit0092","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060031"},{"key":"cit0093","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-1922"},{"key":"cit0094","doi-asserted-by":"publisher","DOI":"10.1038\/nri1371"},{"key":"cit0095","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-4174"},{"key":"cit0096","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210911"},{"key":"cit0097","volume-title":"Presented at: 34th Annual Meeting of the Society for Immunotherapy of Cancer","author":"Kirkwood J","year":"2019"},{"key":"cit0098","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0179431"},{"key":"cit0099","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-18-1495"},{"key":"cit0100","volume-title":"Updated results from the phase 1\/2 PIVOT \u2013 02 study. SITC, 34th annual meeting","author":"Diab A"},{"key":"cit0101","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0216485"},{"key":"cit0102","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-2323"},{"key":"cit0103","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2015.1136044"},{"key":"cit0104","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-0118"},{"key":"cit0105","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-1626"},{"key":"cit0106","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2018.1468955"},{"key":"cit0107","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa4691"},{"key":"cit0108","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1302338"},{"key":"cit0109","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12383"},{"key":"cit0110","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy289"},{"key":"cit0111","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0448-9"},{"key":"cit0112","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy424.056"},{"key":"cit0113","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.36.15_suppl.9560"},{"issue":"13","key":"cit0114","doi-asserted-by":"crossref","first-page":"CT182","DOI":"10.1158\/1538-7445.AM2018-CT182","volume":"78","author":"Dummer R","year":"2018","journal-title":"Cancer Res"},{"key":"cit0115","unstructured":"Roche - Roche announces positive Phase III study results for Tecentriq plus Cotellic and Zelboraf in people with previously untreated BRAF V600 mutation-positive advanced melanoma. [cited 2020 Jan 4]. Available from: https:\/\/www.roche.com\/media\/releases\/med-cor-2019-12-13.htm"},{"key":"cit0116","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.73.7379"},{"key":"cit0117","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.67.1529"},{"key":"cit0118","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-019-0530-6"},{"key":"cit0119","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.08.027"},{"key":"cit0120","doi-asserted-by":"publisher","DOI":"10.1186\/2051-1426-3-S2-P181"},{"key":"cit0121","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2015.12.006"},{"key":"cit0122","first-page":"3","volume":"9","author":"Oble DA","year":"2009","journal-title":"Cancer Immun"},{"key":"cit0123","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960401)77:7<1303::AID-CNCR12>3.0.CO;2-5"},{"key":"cit0124","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-0116"},{"key":"cit0125","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/86.15.1159"},{"key":"cit0126","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.5449"},{"key":"cit0127","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30491"},{"key":"cit0128","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201545849"},{"key":"cit0129","doi-asserted-by":"publisher","DOI":"10.1097\/CJI.0b013e3181fad2b0"},{"key":"cit0130","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01211"},{"key":"cit0131","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-1177"},{"key":"cit0132","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050732"},{"key":"cit0133","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-1879"},{"key":"cit0134","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2016.1277306"},{"key":"cit0135","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.11.9941"},{"key":"cit0136","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.08.071"},{"key":"cit0137","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200210000-00006"},{"key":"cit0138","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1012863"},{"key":"cit0139","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-1055-6"},{"key":"cit0140","doi-asserted-by":"publisher","DOI":"10.1038\/nature14001"},{"key":"cit0141","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa1408"},{"issue":"13","key":"cit0142","first-page":"942","volume":"79","author":"Hu-Lieskovan S","year":"2019","journal-title":"Clin Res"},{"key":"cit0143","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709030"},{"key":"cit0144","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz255"},{"key":"cit0145","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1802357"},{"key":"cit0146","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30106-2"},{"key":"cit0147","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1708539"},{"key":"cit0148","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.01219"},{"key":"cit0149","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-019-0858-3"},{"key":"cit0150","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-16-0577"},{"key":"cit0151","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0198-0"},{"key":"cit0152","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.75.6270"},{"key":"cit0153","doi-asserted-by":"publisher","DOI":"10.7150\/thno.24762"},{"key":"cit0154","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx717"}],"container-title":["Expert Opinion on Investigational Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13543784.2020.1769066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T01:55:15Z","timestamp":1696125315000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/13543784.2020.1769066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,1]]},"references-count":154,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7,2]]}},"alternative-id":["10.1080\/13543784.2020.1769066"],"URL":"https:\/\/doi.org\/10.1080\/13543784.2020.1769066","relation":{},"ISSN":["1354-3784","1744-7658"],"issn-type":[{"value":"1354-3784","type":"print"},{"value":"1744-7658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,1]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieid20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieid20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2020-01-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}