{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T11:25:04Z","timestamp":1770290704720,"version":"3.49.0"},"reference-count":155,"publisher":"Informa UK Limited","issue":"9","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Investigational Drugs"],"published-print":{"date-parts":[[2020,9,1]]},"DOI":"10.1080\/13543784.2020.1772753","type":"journal-article","created":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T02:42:22Z","timestamp":1590028942000},"page":"989-1004","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":6,"title":["New drugs in early development for treating multiple myeloma: all that glitters is not gold"],"prefix":"10.1080","volume":"29","author":[{"given":"Luca","family":"Bertamini","sequence":"first","affiliation":[{"name":"Myeloma Unit, Division of Hematology,  University of Torino, Azienda Ospedaliero-Universitaria Citt\u00e0 della Salute e della Scienza di Torino , Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Bonello","sequence":"additional","affiliation":[{"name":"Myeloma Unit, Division of Hematology,  University of Torino, Azienda Ospedaliero-Universitaria Citt\u00e0 della Salute e della Scienza di Torino , Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Boccadoro","sequence":"additional","affiliation":[{"name":"Myeloma Unit, Division of Hematology,  University of Torino, Azienda Ospedaliero-Universitaria Citt\u00e0 della Salute e della Scienza di Torino , Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4539-6363","authenticated-orcid":false,"given":"Sara","family":"Bringhen","sequence":"additional","affiliation":[{"name":"Myeloma Unit, Division of Hematology,  University of Torino, Azienda Ospedaliero-Universitaria Citt\u00e0 della Salute e della Scienza di Torino , Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2020,9,30]]},"reference":[{"key":"cit0001","unstructured":"Myeloma - Cancer Stat Facts [Internet] . Natl. Cancer Inst. Surveillance, Epidemiol. End Results Progr. [cited 2018 Dec 12 ]. Available from: https:\/\/seer.cancer.gov\/statfacts\/html\/mulmy.html."},{"key":"cit0002","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-116129"},{"key":"cit0003","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.313"},{"key":"cit0004","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12010015"},{"key":"cit0005","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2018.01.004"},{"key":"cit0006","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-017-9707-8"},{"key":"cit0007","doi-asserted-by":"publisher","DOI":"10.1021\/jm801329v"},{"key":"cit0008","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-276626"},{"key":"cit0009","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-3728"},{"key":"cit0010","first-page":"83:106172","author":"Hari P","year":"2019","journal-title":"Leuk Res"},{"key":"cit0011","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2019.05.017"},{"key":"cit0012","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-019-0232-6"},{"key":"cit0013","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-03-213009"},{"key":"cit0014","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nov299"},{"key":"cit0015","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14498"},{"key":"cit0016","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.11.1885"},{"key":"cit0017","doi-asserted-by":"publisher","DOI":"10.1126\/science.1244917"},{"key":"cit0018","doi-asserted-by":"publisher","DOI":"10.1126\/science.1244851"},{"key":"cit0019","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-02-0361"},{"key":"cit0020","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12087"},{"key":"cit0021","doi-asserted-by":"publisher","DOI":"10.1126\/science.1177319"},{"key":"cit0022","author":"Bjorklund CC","year":"2019","journal-title":"Leukemia"},{"key":"cit0023","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b01921"},{"key":"cit0024","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2019.09.080"},{"key":"cit0025","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-02-628669"},{"key":"cit0026","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-1203"},{"key":"cit0027","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-124338"},{"key":"cit0028","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2010.01826.x"},{"key":"cit0029","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-3752"},{"key":"cit0030","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14065"},{"key":"cit0031","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-007-9092-1"},{"key":"cit0032","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-124828"},{"key":"cit0033","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(20)30044-2"},{"key":"cit0034","volume":"134","author":"Mateos M-V","year":"2019","journal-title":"Blood"},{"key":"cit0035","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2019.09.582"},{"key":"cit0036","doi-asserted-by":"publisher","DOI":"10.2217\/fon-2020-0024"},{"key":"cit0037","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-124815"},{"key":"cit0038","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2297"},{"key":"cit0039","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-11-317438"},{"key":"cit0040","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.216"},{"key":"cit0041","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.350"},{"key":"cit0042","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-06-788786"},{"key":"cit0043","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-06-788323"},{"key":"cit0044","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-126015"},{"key":"cit0045","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-99-117026"},{"key":"cit0046","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-124407"},{"key":"cit0047","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.212308"},{"key":"cit0048","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2013.794458"},{"key":"cit0049","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2012.09.008"},{"key":"cit0050","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2014.998067"},{"key":"cit0051","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15058"},{"key":"cit0052","author":"Hajek R","year":"2019","journal-title":"Eur J Haematol"},{"key":"cit0053","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70440-1"},{"key":"cit0054","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606038"},{"key":"cit0055","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2723"},{"key":"cit0056","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-128233"},{"key":"cit0057","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90142-6"},{"key":"cit0058","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2020.1703179"},{"key":"cit0059","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-10-0033"},{"key":"cit0060","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30892"},{"key":"cit0061","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V120.21.1868.1868"},{"key":"cit0062","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30174"},{"key":"cit0063","author":"Lee HC","year":"2019","journal-title":"Blood Cancer J"},{"key":"cit0064","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.168666"},{"key":"cit0065","volume":"130","author":"Ocio E","year":"2017","journal-title":"Blood"},{"key":"cit0066","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.1457"},{"key":"cit0067","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.172"},{"key":"cit0068","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.115"},{"key":"cit0069","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1903455"},{"key":"cit0070","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-06-858852"},{"key":"cit0071","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-122907"},{"key":"cit0072","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-122902"},{"issue":"1","key":"cit0073","first-page":"606","volume":"2","author":"Gasparetto C","year":"2018","journal-title":"HemaSphere"},{"key":"cit0074","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-020-0756-6"},{"key":"cit0075","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2019.12.026"},{"key":"cit0076","volume":"130","author":"Cornell RF","year":"2017","journal-title":"Blood"},{"key":"cit0077","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-08-304022"},{"key":"cit0078","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-05-573741"},{"key":"cit0079","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-04-1670"},{"key":"cit0080","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.175"},{"key":"cit0081","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-131370"},{"key":"cit0082","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-1899"},{"key":"cit0083","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-130290"},{"key":"cit0084","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2017.07.009"},{"key":"cit0085","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2017.1403689"},{"key":"cit0086","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V128.22.4476.4476"},{"key":"cit0087","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2013.03.006"},{"key":"cit0088","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-2526"},{"key":"cit0089","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30375-8"},{"key":"cit0090","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V128.22.3307.3307"},{"key":"cit0091","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(00)00093-X"},{"key":"cit0092","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00035.2007"},{"key":"cit0093","doi-asserted-by":"publisher","DOI":"10.1080\/14712598.2018.1544240"},{"key":"cit0094","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V124.21.3474.3474"},{"key":"cit0095","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0114-0"},{"key":"cit0096","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(19)30249-2"},{"key":"cit0097","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(19)30254-6"},{"key":"cit0098","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-128007"},{"key":"cit0099","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0008"},{"key":"cit0100","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-10-535088"},{"key":"cit0101","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-2422"},{"key":"cit0102","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-09-110858"},{"key":"cit0103","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-691162"},{"key":"cit0104","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2019.37.15_suppl.8012"},{"key":"cit0105","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.05.005"},{"key":"cit0106","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-035857"},{"key":"cit0107","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-2333"},{"key":"cit0108","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.38.0410"},{"key":"cit0109","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1708984"},{"key":"cit0110","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31266-7"},{"key":"cit0111","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1509277"},{"key":"cit0112","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20150089"},{"key":"cit0113","doi-asserted-by":"publisher","DOI":"10.1097\/01.HS9.0000560524.63281.bc"},{"key":"cit0114","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-014-0151-0"},{"key":"cit0115","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30576-X"},{"key":"cit0116","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-019-0196-6"},{"key":"cit0117","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30788-0"},{"key":"cit0118","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1996.d01-1811.x"},{"key":"cit0119","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2019.02.006"},{"key":"cit0120","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V128.22.4486.4486"},{"key":"cit0121","doi-asserted-by":"publisher","DOI":"10.1126\/science.3576199"},{"key":"cit0122","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V76.2.377.377"},{"key":"cit0123","doi-asserted-by":"publisher","DOI":"10.1080\/10428190701760532"},{"key":"cit0124","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2018.08.018"},{"key":"cit0125","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V120.21.728.728"},{"key":"cit0126","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404445"},{"key":"cit0127","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxl069"},{"key":"cit0128","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-12-0087"},{"key":"cit0129","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.02.001"},{"key":"cit0130","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-019-0178-8"},{"key":"cit0131","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0162472"},{"key":"cit0132","doi-asserted-by":"publisher","DOI":"10.1080\/10428190902943077"},{"key":"cit0133","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1609783"},{"key":"cit0134","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)71170-2"},{"key":"cit0135","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.388"},{"key":"cit0136","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.02657"},{"key":"cit0137","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-99-118425"},{"key":"cit0138","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.02.002"},{"key":"cit0139","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-122895"},{"key":"cit0140","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-121805"},{"key":"cit0141","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-126818"},{"key":"cit0142","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11122015"},{"key":"cit0143","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.138"},{"key":"cit0144","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-99-115078"},{"key":"cit0145","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-019-0435-7"},{"key":"cit0146","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2017.148"},{"key":"cit0147","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1817226"},{"key":"cit0148","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-128887"},{"key":"cit0149","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.3160"},{"key":"cit0150","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2016.222"},{"key":"cit0151","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31240-1"},{"key":"cit0152","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1714678"},{"key":"cit0153","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1817249"},{"key":"cit0154","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-99-112093"},{"key":"cit0155","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-0647"}],"container-title":["Expert Opinion on Investigational Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13543784.2020.1772753","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,11]],"date-time":"2020-10-11T14:05:13Z","timestamp":1602425113000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/13543784.2020.1772753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,1]]},"references-count":155,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9,1]]}},"alternative-id":["10.1080\/13543784.2020.1772753"],"URL":"https:\/\/doi.org\/10.1080\/13543784.2020.1772753","relation":{},"ISSN":["1354-3784","1744-7658"],"issn-type":[{"value":"1354-3784","type":"print"},{"value":"1744-7658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,1]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieid20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieid20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2020-03-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}