{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:02:45Z","timestamp":1792638165781,"version":"4.5.0"},"reference-count":68,"publisher":"Informa UK Limited","issue":"10","license":[{"start":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T00:00:00Z","timestamp":1602720000000},"content-version":"unspecified","delay-in-days":44,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Investigational Drugs"],"published-print":{"date-parts":[[2020,10,2]]},"DOI":"10.1080\/13543784.2020.1804853","type":"journal-article","created":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T08:55:07Z","timestamp":1596272107000},"page":"1163-1170","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":72,"title":["Antisense oligonucleotide therapeutics in clinical trials for the treatment of inherited retinal diseases"],"prefix":"10.1080","volume":"29","author":[{"given":"Kanmin","family":"Xue","sequence":"first","affiliation":[{"name":"Wellcome Trust Clinical Research Career Development Fellow, Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford & Honorary Consultant Vitreoretinal Surgeon, Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"MacLaren","sequence":"additional","affiliation":[{"name":"Professor of Ophthalmology, Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford & Honorary Consultant Vitreoretinal Surgeon, Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,9,1]]},"reference":[{"key":"cit0001","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.1.285"},{"key":"cit0002","doi-asserted-by":"publisher","DOI":"10.1016\/1074-5521(94)90039-6"},{"key":"cit0003","doi-asserted-by":"publisher","DOI":"10.1089\/oli.1.1996.6.267"},{"key":"cit0004","first-page":"562","volume":"2","author":"Geary RS","year":"2001","journal-title":"Curr Opin Invest Drugs"},{"key":"cit0005","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.010909.105654"},{"key":"cit0006","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2013.737320"},{"key":"cit0007","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2015.04.005"},{"key":"cit0008","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw236"},{"key":"cit0009","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2376"},{"key":"cit0010","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0002-9394(02)01327-2","volume":"133","author":"Vitravene Study Group","year":"2002","journal-title":"Am J Ophthalmol"},{"key":"cit0011","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.148"},{"key":"cit0012","doi-asserted-by":"publisher","DOI":"10.1212\/NXG.0000000000000323"},{"key":"cit0013","doi-asserted-by":"publisher","DOI":"10.1089\/nat.2020.0868"},{"key":"cit0014","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60756-3"},{"key":"cit0015","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23982"},{"key":"cit0016","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31408-8"},{"key":"cit0017","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1605731113"},{"key":"cit0018","doi-asserted-by":"publisher","DOI":"10.1038\/35888"},{"key":"cit0019","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1716153"},{"key":"cit0020","doi-asserted-by":"publisher","DOI":"10.1089\/nat.2014.0489"},{"key":"cit0021","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0295-0"},{"key":"cit0022","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21337"},{"key":"cit0023","doi-asserted-by":"publisher","DOI":"10.1086\/507318"},{"key":"cit0024","doi-asserted-by":"publisher","DOI":"10.1038\/mtna.2012.3"},{"key":"cit0025","doi-asserted-by":"publisher","DOI":"10.1038\/mtna.2012.21"},{"key":"cit0026","volume":"25","author":"Garanto A","year":"2016","journal-title":"Hum Mol Genet"},{"key":"cit0027","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2016.03.021"},{"key":"cit0028","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2018.07.010"},{"key":"cit0029","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0763-1"},{"key":"cit0030","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199011083231903"},{"key":"cit0031","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.15.6481"},{"key":"cit0032","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2017.10.002"},{"key":"cit0033","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1805055115"},{"key":"cit0034","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-16400"},{"key":"cit0035","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.116.2.165"},{"key":"cit0036","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-0906"},{"key":"cit0037","doi-asserted-by":"publisher","DOI":"10.1097\/01.iae.0000246675.88911.2c"},{"key":"cit0038","first-page":"223","volume":"1","author":"Espinos C","year":"1998","journal-title":"Community Genet"},{"key":"cit0039","doi-asserted-by":"publisher","DOI":"10.1086\/383096"},{"key":"cit0040","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2005.11.010"},{"key":"cit0041","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-6-65"},{"key":"cit0042","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(01)00344-6"},{"key":"cit0043","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5370.1753"},{"key":"cit0044","volume":"60","author":"van Diepen H","year":"2019","journal-title":"IOVS"},{"key":"cit0045","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-019-00729-0"},{"key":"cit0046","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31868-8"},{"key":"cit0047","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0185-5"},{"key":"cit0048","volume":"138","author":"Fry LE","year":"2019","journal-title":"JAMA Ophthalmol"},{"key":"cit0049","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2018.05.014"},{"key":"cit0050","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2015.11"},{"key":"cit0051","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0327-9"},{"key":"cit0052","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx438"},{"key":"cit0053","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-1978-5"},{"key":"cit0054","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22716"},{"key":"cit0055","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2018.02.008"},{"key":"cit0056","doi-asserted-by":"publisher","DOI":"10.1101\/mcs.a002733"},{"key":"cit0057","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-018-0414-9"},{"key":"cit0058","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-003-0970-0"},{"key":"cit0059","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-75402-4_11"},{"key":"cit0060","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds194"},{"key":"cit0061","doi-asserted-by":"publisher","DOI":"10.1038\/mtna.2016.89"},{"key":"cit0062","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01577-8"},{"key":"cit0063","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104297"},{"key":"cit0064","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-019-0013-6"},{"key":"cit0065","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2018.08.006"},{"key":"cit0066","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21030777"},{"key":"cit0067","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv386"},{"key":"cit0068","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2018.156"}],"container-title":["Expert Opinion on Investigational Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13543784.2020.1804853","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T05:24:32Z","timestamp":1620451472000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/13543784.2020.1804853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,1]]},"references-count":68,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10,2]]}},"alternative-id":["10.1080\/13543784.2020.1804853"],"URL":"https:\/\/doi.org\/10.1080\/13543784.2020.1804853","relation":{},"ISSN":["1354-3784","1744-7658"],"issn-type":[{"value":"1354-3784","type":"print"},{"value":"1744-7658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,1]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieid20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieid20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2020-05-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}