{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:13:39Z","timestamp":1791983619739,"version":"4.4.0"},"reference-count":83,"publisher":"Informa UK Limited","issue":"7","license":[{"start":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T00:00:00Z","timestamp":1626652800000},"content-version":"unspecified","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009726","name":"Foundation for Angelman Syndrome Therapeutics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009726","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Investigational Drugs"],"published-print":{"date-parts":[[2021,7,3]]},"DOI":"10.1080\/13543784.2021.1939674","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T07:02:36Z","timestamp":1623394956000},"page":"709-720","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":48,"title":["Therapies in preclinical and clinical development for Angelman syndrome"],"prefix":"10.1080","volume":"30","author":[{"given":"Theodora","family":"Markati","sequence":"first","affiliation":[{"name":"MDUK Oxford Neuromuscular Center, University of Oxford, Oxford, UK"},{"name":"Department of Paediatrics, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Duis","sequence":"additional","affiliation":[{"name":"Section of Genetics & Inherited Metabolic Disease, Department of Pediatrics, Children\u2019s Hospital Colorado, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9270-4061","authenticated-orcid":false,"given":"Laurent","family":"Servais","sequence":"additional","affiliation":[{"name":"MDUK Oxford Neuromuscular Center, University of Oxford, Oxford, UK"},{"name":"Department of Paediatrics, University of Oxford, Oxford, UK"},{"name":"Division of Child Neurology, Centre De R\u00e9f\u00e9rences Des Maladies Neuromusculaires, Department of Pediatrics, University Hospital Li\u00e8ge & University of Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,6,28]]},"reference":[{"key":"cit0001","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3181def138"},{"key":"cit0002","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2012.09.015"},{"key":"cit0003","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36864"},{"key":"cit0004","doi-asserted-by":"publisher","DOI":"10.2147\/TACG.S57386"},{"issue":"3","key":"cit0005","volume":"2","author":"Dagli A","year":"2012","journal-title":"Mol Syndromol"},{"key":"cit0006","volume-title":"Handbook of clinical neurology","author":"Kyllerman M","year":"2013"},{"key":"cit0007","doi-asserted-by":"publisher","DOI":"10.1007\/s10803-020-04861-1"},{"key":"cit0008","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-017-0716-z"},{"key":"cit0009","doi-asserted-by":"publisher","DOI":"10.1038\/ng0197-70"},{"key":"cit0010","doi-asserted-by":"publisher","DOI":"10.1038\/ng0197-74"},{"key":"cit0011","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2016.133"},{"key":"cit0012","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds130"},{"key":"cit0013","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004039"},{"key":"cit0014","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-013-1526-7"},{"key":"cit0015","doi-asserted-by":"publisher","DOI":"10.1097\/01.mop.0000133634.79661.cd"},{"key":"cit0016","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24576"},{"key":"cit0017","author":"Sun J","year":"2020","journal-title":"Sci Rep"},{"key":"cit0018","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2018.01.021"},{"key":"cit0019","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2327"},{"key":"cit0020","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm288"},{"key":"cit0021","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80596-6"},{"key":"cit0022","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2012.04.002"},{"key":"cit0023","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.09.013"},{"key":"cit0024","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027221"},{"key":"cit0025","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.01.074"},{"key":"cit0026","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-019-0205-4"},{"key":"cit0027","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-019-0012-9"},{"issue":"4","key":"cit0028","volume":"48","author":"Sirois CL","year":"2020","journal-title":"Hum Mol Genet"},{"key":"cit0029","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddab104"},{"key":"cit0030","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12060549"},{"key":"cit0031","doi-asserted-by":"publisher","DOI":"10.1126\/science.1233158"},{"key":"cit0032","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010324.pub2"},{"key":"cit0033","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-011-0236-5"},{"key":"cit0034","doi-asserted-by":"publisher","DOI":"10.1002\/aur.2475"},{"key":"cit0035","doi-asserted-by":"publisher","DOI":"10.1038\/srep06445"},{"key":"cit0036","doi-asserted-by":"publisher","DOI":"10.1006\/geno.2001.6543"},{"key":"cit0037","doi-asserted-by":"publisher","DOI":"10.1038\/nature13975"},{"key":"cit0038","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.148"},{"key":"cit0039","doi-asserted-by":"publisher","DOI":"10.2165\/00063030-200721040-00004"},{"key":"cit0040","doi-asserted-by":"publisher","DOI":"10.1038\/nature10726"},{"key":"cit0041","volume-title":"Proceedings of the National Academy of Sciences of the United States of America","author":"Powell WT","year":"2013"},{"key":"cit0042","doi-asserted-by":"publisher","DOI":"10.1101\/gad.242990.114"},{"key":"cit0043","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-018-0228-2"},{"key":"cit0044","doi-asserted-by":"publisher","DOI":"10.1038\/nature12504"},{"key":"cit0045","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2835-2"},{"key":"cit0046","doi-asserted-by":"publisher","DOI":"10.1172\/JCI142574"},{"key":"cit0047","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2009.03.012"},{"key":"cit0048","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2015.236"},{"key":"cit0049","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3004655"},{"key":"cit0050","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2001.0463"},{"key":"cit0051","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011409"},{"key":"cit0052","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2014.01.020"},{"key":"cit0053","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2012.06.002"},{"key":"cit0054","doi-asserted-by":"publisher","DOI":"10.1002\/aur.2418"},{"key":"cit0055","author":"Guan J","year":"2014","journal-title":"Sci Rep"},{"issue":"3","key":"cit0056","volume":"32","author":"Guan J","year":"2018","journal-title":"J Biol Regul Homeost Agents"},{"key":"cit0057","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2010.02.039"},{"key":"cit0058","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1820131116"},{"key":"cit0059","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-2299"},{"key":"cit0060","doi-asserted-by":"publisher","DOI":"10.1667\/RR14879.1"},{"key":"cit0061","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2017.1324847"},{"key":"cit0062","author":"Fava M","year":"2016","journal-title":"Mol Psychiatry"},{"key":"cit0063","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0334-8"},{"key":"cit0064","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2018.10.038"},{"key":"cit0065","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2010.03118.x"},{"key":"cit0066","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2012.03537.x"},{"key":"cit0067","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2016.08.002"},{"key":"cit0068","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-019-3996-x"},{"key":"cit0069","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2019.1704732"},{"key":"cit0070","first-page":"1","author":"Servais L","year":"2021","journal-title":"Expert Opin Investig Drugs"},{"key":"cit0071","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1702752"},{"key":"cit0072","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1710504"},{"key":"cit0073","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2003715"},{"issue":"4","key":"cit0074","volume":"11","author":"Deyle DR","year":"2009","journal-title":"Curr Opin Mol Ther"},{"key":"cit0075","doi-asserted-by":"publisher","DOI":"10.1089\/hum.2018.015"},{"key":"cit0076","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aba9188"},{"key":"cit0077","author":"Sidorov MS","year":"2017","journal-title":"J Neurodev Disord"},{"key":"cit0078","doi-asserted-by":"publisher","DOI":"10.3791\/59668"},{"key":"cit0079","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51281"},{"key":"cit0080","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S172291"},{"key":"cit0081","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2019.11.002"},{"key":"cit0082","doi-asserted-by":"publisher","DOI":"10.1172\/JCI80554"},{"key":"cit0083","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-019-0277-1"}],"container-title":["Expert Opinion on Investigational Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13543784.2021.1939674","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T08:05:28Z","timestamp":1626854728000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/13543784.2021.1939674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,28]]},"references-count":83,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7,3]]}},"alternative-id":["10.1080\/13543784.2021.1939674"],"URL":"https:\/\/doi.org\/10.1080\/13543784.2021.1939674","relation":{},"ISSN":["1354-3784","1744-7658"],"issn-type":[{"value":"1354-3784","type":"print"},{"value":"1744-7658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,28]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieid20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieid20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2021-03-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}