{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T22:58:43Z","timestamp":1786834723276,"version":"build-2736575974"},"reference-count":104,"publisher":"Informa UK Limited","issue":"7","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Investigational Drugs"],"published-print":{"date-parts":[[2022,7,3]]},"DOI":"10.1080\/13543784.2022.2075340","type":"journal-article","created":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T08:08:45Z","timestamp":1652083725000},"page":"715-727","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":9,"title":["Investigational drugs for immune thrombocytopenia"],"prefix":"10.1080","volume":"31","author":[{"given":"Drew","family":"Provan","sequence":"first","affiliation":[{"name":"Centre for Immunology, Blizard Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian C","family":"Newland","sequence":"additional","affiliation":[{"name":"Centre for Immunology, Blizard Institute, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2022,5,11]]},"reference":[{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000812"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-05-578336"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000966"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10040789"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e3283567541"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0000000000000612"},{"key":"e_1_3_4_9_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.103820","article-title":"Recent advances in the mechanisms and treatment of immune thrombocytopenia","volume":"76","author":"Provan D","year":"2022","unstructured":"Provan D, Semple JW. Recent advances in the mechanisms and treatment of immune thrombocytopenia. EBioMedicine. 2022;76:103820.","journal-title":"EBioMedicine"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-06-225565"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.9.2549"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-12-467068"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26036"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26045"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v9.i20.5352"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16775"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.12.5640"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/369533a0"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/369565a0"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90450-2"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a124883"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.23.11104"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.12.3241"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-013-1382-0"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V85.2.391.391"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2009.0062"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118210"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03440.x"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60203-2"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa073275"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-07-514398"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15078"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-021-01575-1"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-021-01047-9"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-021-01965-7"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1159\/000510676"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-015-1793-1"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23900"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.212845"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2021-151321"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(54)91571-8"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(66)92190-8"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.99.1.159s"},{"key":"e_1_3_4_44_1","first-page":"12:181","article-title":"Fc receptors and their interactions with immunoglobulins","author":"Raghavan M","year":"1996","unstructured":"Raghavan M, Bjorkman PJ. Fc receptors and their interactions with immunoglobulins. Annu Rev Cell Dev Biol. 1996;12:181\u2013220.","journal-title":"Annu Rev Cell Dev Biol"},{"key":"e_1_3_4_45_1","first-page":"203:1352","article-title":"A theoretical model of gamma-globulin catabolism","author":"Brambell FW","year":"1964","unstructured":"Brambell FW, Hemmings WA, Morris IG. A theoretical model of gamma-globulin catabolism. Nature. 1964;203:1352\u20131354.","journal-title":"Nature"},{"key":"e_1_3_4_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830150718"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.807396"},{"key":"e_1_3_4_48_1","first-page":"682","article-title":"Unraveling the interaction between fcrn and albumin: opportunities for design of albumin-based therapeutics","volume":"5","author":"Sand KM","year":"2014","unstructured":"Sand KM, Bern M, Nilsen J, et al. Unraveling the interaction between fcrn and albumin: opportunities for design of albumin-based therapeutics. Front Immunol. 2014;5:682.","journal-title":"Front Immunol"},{"key":"e_1_3_4_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01540"},{"key":"e_1_3_4_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2020.07.015"},{"key":"e_1_3_4_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0708960105"},{"key":"e_1_3_4_52_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aan1208"},{"key":"e_1_3_4_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1276"},{"key":"e_1_3_4_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2015.00176"},{"key":"e_1_3_4_55_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI97911"},{"key":"e_1_3_4_56_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2010.187930"},{"key":"e_1_3_4_57_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-05-024539"},{"key":"e_1_3_4_58_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-06-582346"},{"key":"e_1_3_4_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61495-1"},{"key":"e_1_3_4_60_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020002003"},{"key":"e_1_3_4_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25680"},{"key":"e_1_3_4_62_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007600"},{"key":"e_1_3_4_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2009.03.004"},{"key":"e_1_3_4_64_1","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.O113.027722"},{"key":"e_1_3_4_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2765"},{"key":"e_1_3_4_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(01)79003-7"},{"key":"e_1_3_4_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1460"},{"key":"e_1_3_4_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/378303a0"},{"key":"e_1_3_4_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/380634a0"},{"issue":"11","key":"e_1_3_4_70_1","doi-asserted-by":"crossref","first-page":"5429","DOI":"10.4049\/jimmunol.152.11.5429","article-title":"Stimulation of macrophage Fc gamma RIIIA activates the receptor-associated protein tyrosine kinase Syk and induces phosphorylation of multiple proteins including p95Vav and p62\/GAP-associated protein","volume":"152","author":"Darby C","year":"1994","unstructured":"Darby C, Geahlen RL, Schreiber AD. Stimulation of macrophage Fc gamma RIIIA activates the receptor-associated protein tyrosine kinase Syk and induces phosphorylation of multiple proteins including p95Vav and p62\/GAP-associated protein. J Immunol. 1994;152(11):5429\u20135437.","journal-title":"J Immunol"},{"key":"e_1_3_4_71_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0804206"},{"key":"e_1_3_4_72_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132706"},{"key":"e_1_3_4_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00748.x"},{"key":"e_1_3_4_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.63.5.521"},{"key":"e_1_3_4_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2206"},{"key":"e_1_3_4_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114360"},{"key":"e_1_3_4_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2013.04.007"},{"key":"e_1_3_4_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25125"},{"key":"e_1_3_4_79_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.9.6.722"},{"key":"e_1_3_4_80_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.1.288"},{"key":"e_1_3_4_81_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-281170"},{"key":"e_1_3_4_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.11.011"},{"key":"e_1_3_4_83_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-018-0779-z"},{"key":"e_1_3_4_84_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15545"},{"key":"e_1_3_4_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.273"},{"key":"e_1_3_4_86_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.766272"},{"key":"e_1_3_4_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13351"},{"key":"e_1_3_4_88_1","article-title":"Phase I\/II ongoing study of rilzabrutinib, an oral bruton tyrosine kinase inhibitor, in immune thrombocytopenia: extended follow-up and long-term analyses with optimal dose","volume":"19","author":"Kuter D","year":"2019","unstructured":"Kuter D, Tzvetkov N, E M, et al. Phase I\/II ongoing study of rilzabrutinib, an oral bruton tyrosine kinase inhibitor, in immune thrombocytopenia: extended follow-up and long-term analyses with optimal dose. J Thromb Haemost. 2019;19:OC 72.2.","journal-title":"J Thromb Haemost"},{"key":"e_1_3_4_89_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2001130"},{"key":"e_1_3_4_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13746"},{"issue":"18","key":"e_1_3_4_91_1","first-page":"1725","article-title":"Pegcetacoplan versus Eculizumab in PNH","volume":"385","author":"Gurnari C","year":"2021","unstructured":"Gurnari C, Pagliuca S, Maciejewski JP. Pegcetacoplan versus Eculizumab in PNH. N Engl J Med. 2021;385(18):1725.","journal-title":"N Engl J Med"},{"key":"e_1_3_4_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2011.01718.x"},{"key":"e_1_3_4_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07995.x"},{"key":"e_1_3_4_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12388"},{"key":"e_1_3_4_95_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2027760"},{"key":"e_1_3_4_96_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2020-139663"},{"key":"e_1_3_4_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(94)90095-7"},{"key":"e_1_3_4_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2009.05.011"},{"key":"e_1_3_4_99_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI5388"},{"key":"e_1_3_4_100_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.11.6893"},{"key":"e_1_3_4_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/72162"},{"key":"e_1_3_4_102_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07039.x"},{"key":"e_1_3_4_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10681"},{"key":"e_1_3_4_104_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1669921"},{"key":"e_1_3_4_105_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16009"},{"key":"e_1_3_4_106_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506348"}],"container-title":["Expert Opinion on Investigational Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13543784.2022.2075340","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T08:37:18Z","timestamp":1732091838000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/13543784.2022.2075340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,11]]},"references-count":104,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7,3]]}},"alternative-id":["10.1080\/13543784.2022.2075340"],"URL":"https:\/\/doi.org\/10.1080\/13543784.2022.2075340","relation":{},"ISSN":["1354-3784","1744-7658"],"issn-type":[{"value":"1354-3784","type":"print"},{"value":"1744-7658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,11]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieid20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieid20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2022-03-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}