{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T01:13:10Z","timestamp":1783041190659,"version":"3.54.6"},"reference-count":40,"publisher":"Informa UK Limited","issue":"7","funder":[{"name":"not supported by any funding"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Investigational Drugs"],"published-print":{"date-parts":[[2023,7,3]]},"DOI":"10.1080\/13543784.2023.2242768","type":"journal-article","created":{"date-parts":[[2023,7,29]],"date-time":"2023-07-29T03:38:08Z","timestamp":1690601888000},"page":"635-642","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":9,"title":["Phosphodiesterase 5 inhibitors: preclinical and early-phase breakthroughs for impotence treatments"],"prefix":"10.1080","volume":"32","author":[{"given":"Zachary","family":"Melchiode","sequence":"first","affiliation":[{"name":"Ochsner Clinical School, University of Queensland, New Orleans, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tivoli","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Dawood","sequence":"additional","affiliation":[{"name":"Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham A.","family":"Bobo","sequence":"additional","affiliation":[{"name":"Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1284-959X","authenticated-orcid":false,"given":"Wayne J.G.","family":"Hellstrom","sequence":"additional","affiliation":[{"name":"Department of Urology, Tulane University School of Medicine, New Orleans, LA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,8]]},"reference":[{"key":"e_1_3_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.1999.00142.x"},{"key":"e_1_3_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12074"},{"key":"e_1_3_6_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2019.1659244"},{"issue":"2","key":"e_1_3_6_6_1","first-page":"e128","article-title":"Sildenafil and furosemide associated ototoxicity: consideration of drug-drug interactions, synergy, and broader clinical relevance","volume":"20","author":"Skeith L","year":"2013","unstructured":"Skeith L, Yamashita C, Mehta S, et al. Sildenafil and furosemide associated ototoxicity: consideration of drug-drug interactions, synergy, and broader clinical relevance. J Popul Ther Clin Pharmacol. 2013;20(2):e128\u201331.","journal-title":"J Popul Ther Clin Pharmacol"},{"key":"e_1_3_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000081053.97792.da"},{"key":"e_1_3_6_8_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728214.2015.1021682"},{"key":"e_1_3_6_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S39727"},{"key":"e_1_3_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2008.03107.x"},{"key":"e_1_3_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2009.01456.x"},{"key":"e_1_3_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2007.00723.x"},{"key":"e_1_3_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.01817.x"},{"key":"e_1_3_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.03.025"},{"key":"e_1_3_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsxm.2016.05.011"},{"key":"e_1_3_6_16_1","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.220057"},{"key":"e_1_3_6_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161209789206971"},{"issue":"7","key":"e_1_3_6_18_1","first-page":"661","article-title":"Udenafil, a long-acting PDE5 inhibitor for erectile dysfunction","volume":"7","author":"Salem EA","year":"2006","unstructured":"Salem EA, Kendirci M, Hellstrom WJ. Udenafil, a long-acting PDE5 inhibitor for erectile dysfunction. Curr Opin Invest Drugs. 2006 Jul;7(7):661\u2013669.","journal-title":"Curr Opin Invest Drugs"},{"key":"e_1_3_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2012.08.243"},{"key":"e_1_3_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.2943"},{"key":"e_1_3_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201600445"},{"key":"e_1_3_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(18)33160-4"},{"issue":"7","key":"e_1_3_6_23_1","first-page":"407","article-title":"Phosphodiesterase-5 (PDE5) Inhibitors in the Management of Erectile Dysfunction","volume":"38","author":"Huang SA","year":"2013","unstructured":"Huang SA, Lie JD. Phosphodiesterase-5 (PDE5) Inhibitors in the Management of Erectile Dysfunction. P T. 2013 Jul;38(7):407\u2013419.","journal-title":"P T"},{"key":"e_1_3_6_24_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2013.799665"},{"key":"e_1_3_6_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2010.165"},{"key":"e_1_3_6_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2009.03404.x"},{"key":"e_1_3_6_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2005.02553.x"},{"key":"e_1_3_6_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3901331"},{"key":"e_1_3_6_29_1","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.2014.32.1.18"},{"key":"e_1_3_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2008.00945.x"},{"key":"e_1_3_6_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijir.2012.44"},{"key":"e_1_3_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.01926.x"},{"key":"e_1_3_6_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/00498250701708521"},{"key":"e_1_3_6_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpdd.1108"},{"key":"e_1_3_6_35_1","doi-asserted-by":"crossref","unstructured":"Alshehri YM Al-Majed AA Attwa MW et al. Lodenafil. Profiles Drug Subst Excip Relat Methodol. 2022;47:113\u2013147.","DOI":"10.1016\/bs.podrm.2021.10.004"},{"key":"e_1_3_6_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2008.01079.x"},{"key":"e_1_3_6_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2010.01711.x"},{"key":"e_1_3_6_38_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728214.2010.480973"},{"key":"e_1_3_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.06.055"},{"key":"e_1_3_6_40_1","unstructured":"BioSpace. Surface Logix reports data on SLX-2101 for erectile dysfunction at the American Urological Association meeting. BioSpace 2006. (Accessed Mar 3 2023). https:\/\/www.biospace.com\/article\/releases\/surface-logix-reports-data-on-slx-2101-for-erectile-dysfunction-at-the-american-urological-association-meeting-\/."},{"key":"e_1_3_6_41_1","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.200007"},{"key":"e_1_3_6_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aju.2016.04.002"}],"container-title":["Expert Opinion on Investigational Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13543784.2023.2242768","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T07:02:38Z","timestamp":1710313358000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/13543784.2023.2242768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,3]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7,3]]}},"alternative-id":["10.1080\/13543784.2023.2242768"],"URL":"https:\/\/doi.org\/10.1080\/13543784.2023.2242768","relation":{},"ISSN":["1354-3784","1744-7658"],"issn-type":[{"value":"1354-3784","type":"print"},{"value":"1744-7658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,3]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieid20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieid20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2023-05-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}