{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T12:24:10Z","timestamp":1768566250129,"version":"3.49.0"},"reference-count":49,"publisher":"Informa UK Limited","issue":"12","funder":[{"name":"RedHill Biopharma, Ltd, Tel Aviv, Israel"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Investigational Drugs"],"published-print":{"date-parts":[[2023,12,2]]},"DOI":"10.1080\/13543784.2023.2284385","type":"journal-article","created":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T09:32:18Z","timestamp":1700127138000},"page":"1095-1103","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":4,"title":["Upamostat: a serine protease inhibitor for antiviral, gastrointestinal, and anticancer indications"],"prefix":"10.1080","volume":"32","author":[{"given":"TF.","family":"Plasse","sequence":"first","affiliation":[{"name":"RedHill Biopharma, Ltd, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Fathi","sequence":"additional","affiliation":[{"name":"RedHill Biopharma, Ltd, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Fehrmann","sequence":"additional","affiliation":[{"name":"CEEF Solutions, Beaconsfield, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GA.","family":"McComsey","sequence":"additional","affiliation":[{"name":"CEEF Solutions, Beaconsfield, Quebec, Canada"},{"name":"University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2023,11,23]]},"reference":[{"key":"e_1_3_4_3_1","first-page":"1","volume-title":"Encyclopedia of respiratory medicine","author":"Owen CA","year":"2006","unstructured":"Owen CA. Serine Proteases, in Laurent GJ, Shapiro SD. Encyclopedia of respiratory medicine. Serine Proteases. Amsterdam: Elsevier; 2006. p. 1\u201310."},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115817"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309147"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-1745"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2011.291"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-021-00418-x"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-75474-1_11"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm960668h"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(99)00541-7"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20192"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH04-11-0712"},{"key":"e_1_3_4_14_1","volume-title":"American Association for Cancer Research","author":"Oldenburg E","unstructured":"Oldenburg E, Schar CR, Lange EL, et al. New potential therapeutic applications of WX-UK1, as a specific and potent inhibitor of human trypsin-like proteases; American Association for Cancer Research; Chicago. Proc. AACR 2018, Abstract 784."},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.052"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2022.12.003"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.117.245027"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.04.005"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.930959"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.163"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076667"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2007.08.083"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tice.2022.101918"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2018.10.011"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-012-1006-4"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo_00000555"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.12.5.1013"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1089\/pancan.2019.0014"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.934931"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2014.2052"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2001.1976"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M401430200"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1999"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.880422"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.048876"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312094"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00649-19"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-017-0824-3"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00398-21"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.1991.tb01589.x"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.3109\/00498254.2013.767481"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19970703)72:1<1:AID-IJC1>3.0.CO;2-Z"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/28961"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.1159\/000151736"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.62"},{"key":"e_1_3_4_46_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2013.31.15_suppl.508"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.100849"},{"key":"e_1_3_4_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-022-02518-7"},{"key":"e_1_3_4_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2022.06.054"},{"key":"e_1_3_4_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.870493"},{"key":"e_1_3_4_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.13052"}],"container-title":["Expert Opinion on Investigational Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13543784.2023.2284385","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T15:30:00Z","timestamp":1727278200000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/13543784.2023.2284385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,23]]},"references-count":49,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12,2]]}},"alternative-id":["10.1080\/13543784.2023.2284385"],"URL":"https:\/\/doi.org\/10.1080\/13543784.2023.2284385","relation":{},"ISSN":["1354-3784","1744-7658"],"issn-type":[{"value":"1354-3784","type":"print"},{"value":"1744-7658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,23]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieid20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieid20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2023-05-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}