{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T04:39:01Z","timestamp":1793853541009,"version":"4.6.1"},"reference-count":64,"publisher":"Informa UK Limited","issue":"12","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Investigational Drugs"],"published-print":{"date-parts":[[2023,12,2]]},"DOI":"10.1080\/13543784.2023.2288073","type":"journal-article","created":{"date-parts":[[2023,11,25]],"date-time":"2023-11-25T16:20:45Z","timestamp":1700929245000},"page":"1123-1131","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":10,"title":["Experimental drugs for the treatment of idiopathic intracranial hypertension (IIH): shedding light on phase I and II trials"],"prefix":"10.1080","volume":"32","author":[{"given":"Pavan","family":"Khatkar","sequence":"first","affiliation":[{"name":"Medical school Imperial College London, UK"},{"name":"Birmingham Neuro-Ophthalmology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6143-2306","authenticated-orcid":false,"given":"Jess C","family":"Hubbard","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, Institute of Clinical Sciences, University of Birmingham, Birmingham, UK"},{"name":"Translational Brain Science, Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Hill","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences, Institute of Clinical Sciences, University of Birmingham, Birmingham, UK"},{"name":"Translational Brain Science, Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra J","family":"Sinclair","sequence":"additional","affiliation":[{"name":"Translational Brain Science, Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, UK"},{"name":"Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK"},{"name":"Department of Neurology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6314-4437","authenticated-orcid":false,"given":"Susan P","family":"Mollan","sequence":"additional","affiliation":[{"name":"Birmingham Neuro-Ophthalmology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK"},{"name":"Translational Brain Science, Institute of Metabolism and Systems Research, University of Birmingham, Edgbaston, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,11,25]]},"reference":[{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-317440"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-022-11402-6"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.14125"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-021-01321-8"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2023.01.016"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.12.5.1"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2023.2206567"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-018-0238-5"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.12.040"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/CPJ.0000000000001063"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-026573"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000000684"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/01658107.2017.1334218"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.145346"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.1812"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.17241"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/01658107.2022.2162089"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.125348"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21774"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-22-0108"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.0659"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000200839"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/life11050417"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000201064"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3312"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13739"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcz050"},{"key":"e_1_3_5_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad003"},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/01658107.2022.2153874"},{"key":"e_1_3_5_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/life11060472"},{"key":"e_1_3_5_33_1","volume-title":"The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses","author":"GA W","year":"2014","unstructured":"GA W, Wells G, Shea B, editors. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. 2014 https:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp"},{"key":"e_1_3_5_34_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.118.219766"},{"key":"e_1_3_5_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2007.01569.x"},{"key":"e_1_3_5_36_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-2011"},{"key":"e_1_3_5_37_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.3.872"},{"key":"e_1_3_5_38_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0729"},{"key":"e_1_3_5_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcg085"},{"issue":"6","key":"e_1_3_5_40_1","first-page":"569","article-title":"Idiopathic intracranial hypertension: a unifying neuroendocrine hypothesis through the adrenal-brain axis","volume":"33","author":"Salpietro V","year":"2012","unstructured":"Salpietro V, Polizzi A, Bert\u00e8 LF, et al. Idiopathic intracranial hypertension: a unifying neuroendocrine hypothesis through the adrenal-brain axis. Neuro Endocrinol Lett. 2012;33(6):569\u2013573.","journal-title":"Neuro Endocrinol Lett"},{"issue":"4","key":"e_1_3_5_41_1","first-page":"495","article-title":"Recent advances in the discovery of 11beta-HSD1 inhibitors","volume":"11","author":"Boyle CD","year":"2008","unstructured":"Boyle CD. Recent advances in the discovery of 11beta-HSD1 inhibitors. Curr Opin Drug Discovery Dev. 2008 Jul;11(4):495\u2013511.","journal-title":"Curr Opin Drug Discovery Dev"},{"key":"e_1_3_5_42_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa766"},{"key":"e_1_3_5_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00034.2006"},{"key":"e_1_3_5_44_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aan0972"},{"key":"e_1_3_5_45_1","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-198511000-00007"},{"key":"e_1_3_5_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00249613"},{"key":"e_1_3_5_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(92)90204-4"},{"key":"e_1_3_5_48_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.6.2427"},{"key":"e_1_3_5_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-10-110"},{"key":"e_1_3_5_50_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2000.279.3.C541"},{"issue":"1","key":"e_1_3_5_51_1","first-page":"1","article-title":"Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling","volume":"53","author":"Ferguson SS","year":"2001","unstructured":"Ferguson SS. Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. Pharmacol Rev. 2001 Mar;53(1):1\u201324.","journal-title":"Pharmacol Rev"},{"key":"e_1_3_5_52_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M604291200"},{"key":"e_1_3_5_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12225"},{"key":"e_1_3_5_54_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab608"},{"key":"e_1_3_5_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-015-1945-7"},{"key":"e_1_3_5_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcad272"},{"key":"e_1_3_5_57_1","doi-asserted-by":"publisher","DOI":"10.2147\/EB.S404642"},{"key":"e_1_3_5_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1085799"},{"key":"e_1_3_5_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2012.01561.x"},{"key":"e_1_3_5_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0029(20010101)52:1<49:AID-JEMT7>3.0.CO;2-C"},{"key":"e_1_3_5_61_1","doi-asserted-by":"publisher","DOI":"10.1177\/03331024231197118"},{"key":"e_1_3_5_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000001902"},{"key":"e_1_3_5_63_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2021.1931127"},{"key":"e_1_3_5_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.14026"},{"key":"e_1_3_5_65_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000201007"},{"key":"e_1_3_5_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcab202"}],"container-title":["Expert Opinion on Investigational Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13543784.2023.2288073","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T15:30:13Z","timestamp":1727278213000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/13543784.2023.2288073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,25]]},"references-count":64,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12,2]]}},"alternative-id":["10.1080\/13543784.2023.2288073"],"URL":"https:\/\/doi.org\/10.1080\/13543784.2023.2288073","relation":{},"ISSN":["1354-3784","1744-7658"],"issn-type":[{"value":"1354-3784","type":"print"},{"value":"1744-7658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,25]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieid20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieid20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2023-10-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}